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Preparation method and application of composite fluorescent probe taking nanowire as carrier

A composite fluorescence, nanowire technology, applied in fluorescence/phosphorescence, chemical instruments and methods, luminescent materials, etc., can solve the problems of forming ratio-type rare earth fluorescent probes, carbon quantum dots cannot be effectively loaded, etc., and achieves low detection limit. , the effect of narrow radiation band and high luminous intensity

Pending Publication Date: 2022-04-26
EAST CHINA UNIV OF SCI & TECH +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the deficiencies of the prior art and solve the problem that carbon quan

Method used

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  • Preparation method and application of composite fluorescent probe taking nanowire as carrier
  • Preparation method and application of composite fluorescent probe taking nanowire as carrier
  • Preparation method and application of composite fluorescent probe taking nanowire as carrier

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Embodiment 1

[0039] Glycine (Gly), ethylene glycol, terbium nitrate (Tb(NO 3 ) 3 ·6H 2 O, 99.99%), trimesic acid (H 3 BTC), N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES) were purchased from Shanghai Macklin Biochemical Technology Co., Ltd. Glucose (Glu), Urea (UA), NaH 2 PO 4 2H 2 O, metal salt (AlCl 3 , CuCl 2 , NaCl, KCl, CaCl 2 ) was purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Dopamine (DA), ascorbic acid (AA), glutamic acid (Glc), histidine (His), tyrosine (Tyr), aspartic acid (Asp), arginine (Arg), valine ( Val) and oleic acid (OA) were purchased from Aladdin Chemical Reagent Co., Ltd. Ultrapure water was prepared by a Milli-Q apparatus (Millipore, Bedford, MA, USA).

[0040] In the first step, 500 mg of glycine was weighed and dissolved in 25 mL of a mixed solution (deionized water: ethylene glycol = 15 mL: 10 mL), and sonicated at room temperature until completely dissolved to obtain a transparent liquid. Then the obtained solution was trans...

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Abstract

The invention discloses a preparation method and application of a composite fluorescent probe with a nanowire as a carrier, and the preparation method comprises the following steps: dispersing a hydroxyapatite nanowire (HAPNWs) aqueous solution, a terbium nitrate (Tb (NO3) 3.6 H2O) aqueous solution and a trimesic acid (H3BTC) ethanol solution in deionized water to prepare a white precipitate (HAPNWs-Tb/MOF); and then dispersing the HAPNWs-Tb/MOF solution and a carbon quantum dot (CDs) solution in deionized water, and carrying out shaking table oscillation overnight to obtain the ratio type fluorescent probe solution HAPNWs-CDs-Tb/MOF of the composite Tb-MOF and the carbon quantum dot by taking the hydroxyapatite nanowire as the carrier. According to the ratio type rare earth fluorescent probe for measuring dopamine, the preparation method of the probe is simple, conditions are mild, and operation is easy. In the dopamine detection process, high sensitivity of fluorescence is utilized, the whole process is convenient, and the result is accurate.

Description

technical field [0001] The invention relates to the field of inorganic fluorescent materials and the field of analysis and detection of biological small molecules, in particular to a preparation method of a composite fluorescent probe with nanowires as a carrier and a fluorescence detection method of dopamine in solution using the probe. Background technique [0002] Dopamine (DA) is a monoamine synthesized in the nervous tissue and adrenal glands of mammals. As an important neurotransmitter, it participates in the regulation of various physiological functions of the central nervous system and is secreted by the hypothalamus and pituitary gland. The physical basis of brain function. If the regulation of the dopamine system is impaired, its content will deviate from the normal secretion level, causing Parkinson's disease, Alzheimer's disease, schizophrenia and other diseases. Therefore, the development of a high-sensitivity detection method for dopamine is of great significa...

Claims

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Application Information

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IPC IPC(8): C09K11/06C09K11/65C09K11/02G01N21/64
CPCC09K11/06C09K11/65C09K11/025C09K11/02G01N21/6428G01N2021/6432G01N2021/6421C09K2211/182
Inventor 张磊孙梦谣屠炳芳任兴发陈再洁刘德云张维冰
Owner EAST CHINA UNIV OF SCI & TECH