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Application of acoustic hedgehog in preparation of aortic dissection auxiliary diagnostic reagent

A technology for aortic dissection and sonic hedgehog, applied in the field of medicine, can solve the problems of unexplained diagnosis and prediction functions, and achieve the effect of good diagnostic value

Pending Publication Date: 2022-04-26
NANJING MEDICAL UNIV
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Problems solved by technology

However, its diagnostic and predictive role in the development of AD has not yet been elucidated, and further exploration is needed

Method used

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  • Application of acoustic hedgehog in preparation of aortic dissection auxiliary diagnostic reagent
  • Application of acoustic hedgehog in preparation of aortic dissection auxiliary diagnostic reagent
  • Application of acoustic hedgehog in preparation of aortic dissection auxiliary diagnostic reagent

Examples

Experimental program
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Embodiment 1

[0023] Example 1 Serum marker sample test in patients with aortic dissection

[0024] Aiming at the possibility that the up-regulation of shh and the activation of the Hedgehog signaling pathway found in our experiments may be involved in the occurrence of AD, we conducted a serum marker sample test and randomly divided them into groups according to gender and age, selecting 160 healthy people as controls and 160 patients with aortic dissection , ELISA experiments were performed to verify whether SHH could determine whether patients had aortic dissection. The experimental steps are as follows:

[0025] (1) Preparatory work before testing

[0026] ①Take out the kit and samples from the refrigerator 1 hour in advance, and equilibrate to room temperature.

[0027] ②Dilution of 20× washing buffer: dilute with distilled water at 1:20, that is, 1 part of 20× washing buffer plus 19 parts of distilled water.

[0028] ③ Reagents and consumables required for the experiment:

[0029]...

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Abstract

The invention discloses application of an acoustic hedgehog factor in preparation of an aortic dissection auxiliary diagnostic reagent. The sound hedgehog factor is used as a biomarker to be applied to preparation of an aortic dissection auxiliary diagnostic reagent. The reagent for quantitatively detecting the sound hedgehog factors is applied to preparation of an aortic dissection auxiliary diagnostic reagent. The reagent for quantitatively detecting the sound hedgehog factor is an ELISA reagent for detecting the sound hedgehog factor. The invention finds that the SHH can be used as a biomarker for auxiliary diagnosis of the aortic dissection for the first time. As a biomarker, the SHH can well distinguish healthy people from aortic dissection patients. When the SHH is used as a biomarker to distinguish a normal control group from an aortic dissection group, the area under an ROC curve is 0.9445, the specificity is 74.84%, and the SHH has a good diagnostic value on the aortic dissection.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of Sonic hedgehog (SHH) in the preparation of auxiliary diagnostic reagents for aortic dissection. Background technique [0002] Aortic dissection (AD) refers to a fatal vascular disease in which blood flows into the middle layer of the aortic wall through the tear port to form a dissection hematoma caused by various factors, and the false lumen extends along the aortic wall to both sides with the systole of the heart. AD has the characteristics of critical condition and high mortality, which seriously threatens the safety of human life. Therefore, early and accurate diagnosis is the key. At present, the diagnosis of AD mainly relies on imaging methods, but it lacks timeliness, convenience and rapidity. Serological examination has become an important clinical examination method because of its sensitivity, simplicity and economy, and is widely used i...

Claims

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Application Information

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IPC IPC(8): G01N33/535G01N33/558
CPCG01N33/535G01N33/558
Inventor 季勇张佳唐欣谢利平
Owner NANJING MEDICAL UNIV
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