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Panax notoginseng total saponin myocardial targeting liposome and preparation method thereof

A technology of notoginseng total saponins and targeted liposomes, which can be used in liposome delivery, pharmaceutical formulations, cardiovascular system diseases, etc., and can solve the problem of insufficient targeting of notoginseng total saponins liposomes Not good enough to achieve obvious protective effects, improve myocardial enzyme activity, and inhibit the production of inflammatory factors

Pending Publication Date: 2022-04-29
GUANGXI MEDICAL UNIVERSITY
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Problems solved by technology

The content of this technology is that after the total saponins of Panax notoginseng are encapsulated in liposomes, it can be targeted to reach the lesion site, but the targeting effect of the liposome itself is used, and the targeting effect is not good enough, and there is no special treatment for the myocardium. targeted effect
[0006] At present, the targeting of liposomes of Panax notoginseng saponins is still not good enough. Therefore, on the basis of the existing research on liposomes of Panax notoginseng saponins, further optimization research is carried out to obtain a cardioprotective effect. Myocardial targeting liposomes of Panax notoginseng saponins, and the development of new dosage forms of Panax notoginseng saponins, providing preparations with higher bioavailability for the treatment of myocardial injury is the current key research direction

Method used

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  • Panax notoginseng total saponin myocardial targeting liposome and preparation method thereof
  • Panax notoginseng total saponin myocardial targeting liposome and preparation method thereof
  • Panax notoginseng total saponin myocardial targeting liposome and preparation method thereof

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Embodiment Construction

[0034] The technical solutions of the present invention will be further limited below in conjunction with specific embodiments, but the scope of protection is not limited to the descriptions made.

[0035] Preparation and Quality Evaluation of Myocardial Targeting Liposomes of Panax notoginseng Saponins:

[0036] Prepare notoginseng total saponins cardiomyocyte targeting liposome (PAC-L-PNS) by thin-film dispersion ultrasonic method, and the prescription is as follows: Accurately weigh 120 mg of egg yolk lecithin, 13.3 mg of cholesterol, and 1.7 mg of esmolol analogue (PAC) Put it in a round-bottom flask, add 10mL of dichloromethane to dissolve it, and rotate it under reduced pressure in a constant temperature water bath at 40°C for 1 hour. At this time, a layer of light yellow transparent lipid film is formed on the round-bottom flask; accurately weigh 10mg of Dissolve PNS in 10 mL of purified water to make 1 mg·mL-1 PNS solution. Add the PNS solution into a round-bottomed fl...

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Abstract

The invention relates to the technical field of medicine preparation, in particular to a panax notoginseng saponins myocardial targeting liposome and a preparation method thereof. According to the present invention, the panax notoginseng total saponin myocardial targeting liposome is provided, the panax notoginseng total saponin myocardial targeting liposome comprises panax notoginseng total saponin, phospholipid, cholesterol and an esmolol analogue, a film dispersion ultrasonic method is adopted to prepare the panax notoginseng total saponin myocardial targeting liposome, the mass ratio of the phospholipid to the cholesterol is 9: 1, the ultrasonic power is 63 W, and the hydration time is 15 min; the targeting liposome has strong targeting in vivo and in vitro, has an obvious protection effect on myocardial cell inflammatory injury caused by hypoxia / reoxygenation, and has a protection effect on mice with myocardial injury caused by endotoxin in vivo.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a myocardium targeting liposome of Panax notoginseng saponins and a preparation method thereof. Background technique [0002] Panax Notoginseng Saponins (PNS) is the total saponins extracted and processed from the main root or rhizome of Panax notoginseng. [0003] PNS contains a variety of monomeric saponins, including notoginsenoside R1, ginsenoside Rg1, and ginsenoside Rb1. Because PNS is easily decomposed in the gastric acid environment, the permeability of the intestinal mucosa is low, resulting in low oral bioavailability, which limits the clinical application of its oral preparations. In addition, due to the lack of clear targeting, injection administration is easy to cause Adverse reactions limit the clinical application of its injection preparations. Establishing a new drug delivery system for PNS has become one of the hotspots in the medicinal research of...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K9/127A61K47/22A61K47/24A61K47/28A61P9/04A61K125/00
CPCA61K36/258A61K9/1277A61K47/24A61K47/28A61K47/22A61P9/04
Inventor 黄建春陈红丽谢佳秀韦柱梅黄玉鹏冯慧王梦瑶高品梅
Owner GUANGXI MEDICAL UNIVERSITY
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