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A kind of blood cell pulse counting error correction method and correction device

An error correction and pulse counting technology, which is applied in the field of blood cell pulse counting error correction method and correction device, can solve the problems of a large difference in the time between the rising edge and the falling edge of the pulse waveform, and the inability to correct the pulse amplitude data, so as to improve the accuracy and reliability effects

Active Publication Date: 2022-07-05
南京颐兰贝生物科技有限责任公司
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Problems solved by technology

[0005] In order to overcome the deficiencies of the prior art, the purpose of the present invention is to provide a blood cell pulse counting error correction method, which aims to solve the correction method in the prior art, because the time difference between the rising edge and the falling edge of the pulse waveform is very large, it cannot be corrected The problem of accurate correction of pulse amplitude data

Method used

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  • A kind of blood cell pulse counting error correction method and correction device
  • A kind of blood cell pulse counting error correction method and correction device
  • A kind of blood cell pulse counting error correction method and correction device

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no. 1 approach

[0062] The present invention provides such as Figure 1-Figure 4 A blood cell pulse counting error correction method is shown, including the following steps:

[0063] Step S1: collecting reference pulse signals generated by a plurality of standard particles continuously passing through the gemstone hole under a constant pressure state.

[0064] Specifically: the standard particle is a latex spherical substance with a known volume and a negligible error. The characteristics of the standard particle are consistent with the characteristics of blood cells. Each standard particle generates a pulse signal after passing through the gem hole, using negative pressure. The pump provides a constant flow rate, so that the pulse amplitude generated by the standard particles after passing through the gemstone hole will be within the range of extremely small deviation, and the pulse signal generated by this is used as the reference signal for calibrating the gemstone hole. A calibration too...

no. 2 approach

[0102] like Figure 5 As shown, the second embodiment of the present invention provides a blood cell pulse counting error correction device, including:

[0103] The first acquisition module is used to collect the reference pulse signal generated by the standard particles passing through the gem hole, and send it to the storage module one;

[0104] The second acquisition module is used to collect the actual pulse signal generated by the blood cells passing through the gem hole, and send it to the second storage module;

[0105] The identification module is used to identify the valid reference pulse signal in the first storage module;

[0106] The calculation module is used to calculate the calibration coefficient according to the ratio of the sampling data of the rising edge and the falling edge of the valid reference pulse signal;

[0107] The calibration module is used to refit the pulse waveform of the actual pulse signal according to the calibration coefficient.

[0108]...

no. 3 approach

[0111] like Image 6 As shown, the third embodiment of the present invention provides a network-side server, including: at least one processor 301; and a memory 302 communicatively connected to the at least one processor; wherein the memory 302 stores a Instructions executed by the at least one processor 301, the instructions being executed by the at least one processor 301 to enable the at least one processor 301 to execute the above-described method for correcting a blood cell pulse count error.

[0112] The memory 302 and the processor 301 are connected by a bus, and the bus may include any number of interconnected buses and bridges, and the bus connects one or more processors 301 and various circuits of the memory 302 together. The bus may also connect together various other circuits, such as peripherals, voltage regulators, and power management circuits, which are well known in the art and therefore will not be described further herein. The bus interface provides the int...

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Abstract

The invention discloses a blood cell pulse counting error correction method. Determine whether the reference pulse signal is valid; extract the valid reference pulse signal, calibrate the gem hole error, and calculate the calibration coefficient; collect the actual pulse signal of blood cells passing through the gem hole, and extract the pulse waveform of the actual pulse signal; use the calibration coefficient to re-fit The falling edge pulse waveform of the actual pulse signal. The method first collects the pulse waveform of the standard particle, and then calculates the correction coefficient of the gem hole by analyzing the pulse waveform of the standard particle, and uses the correction coefficient to re-fit the actually collected blood cell pulse waveform, so as to accurately measure the pulse amplitude data. The correction greatly improves the accuracy and reliability of blood counts.

Description

technical field [0001] The invention belongs to the technical field of signal analysis and identification processing, and in particular relates to a blood cell pulse counting error correction method and correction device. Background technique [0002] In the field of medical hematology detection, the detection scheme based on Coulter's principle is more commonly used. In the circuit of the small hole, the resistance between the two points inside and outside the small hole tube is transiently changed, and a potential pulse is generated. The size and number of the pulse signal are proportional to the size and number of the particles. The current hematology analyzer also performs detection according to this method, but the detection needs to be accurate, and a single cell needs to pass through the axial area of ​​the small hole in a straight line. In this case, the voltage amplitude of Coulter's principle can accurately reflect the size of the cell. Other paths of a single cel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N15/10
CPCG01N15/1012G01N2015/1006
Inventor 陈鹏
Owner 南京颐兰贝生物科技有限责任公司
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