Cell function annotation method, device, equipment and medium

A functional annotation and cell technology, applied in proteomics, genomics, instrumentation, etc., can solve the problem of poor accuracy of cell function annotation and achieve the effect of improving accuracy

Pending Publication Date: 2022-05-13
TENCENT TECH (SHENZHEN) CO LTD
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Problems solved by technology

[0004] However, since cell function is determined by the selective expression of genes in cells and the int

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  • Cell function annotation method, device, equipment and medium
  • Cell function annotation method, device, equipment and medium
  • Cell function annotation method, device, equipment and medium

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[0032] In order to make the purpose, technical solution and advantages of the present application clearer, the implementation manners of the present application will be further described in detail below in conjunction with the accompanying drawings.

[0033] Artificial Intelligence (AI) is a theory, method, technology and application system that uses digital computers or machines controlled by digital computers to simulate, extend and expand human intelligence, perceive the environment, acquire knowledge and use knowledge to obtain the best results. In other words, artificial intelligence is a comprehensive technique of computer science that attempts to understand the nature of intelligence and produce a new kind of intelligent machine that can respond in a similar way to human intelligence. Artificial intelligence is to study the design principles and implementation methods of various intelligent machines, so that the machines have the functions of perception, reasoning and de...

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Abstract

The invention discloses a cell function annotation method, device and equipment and a medium, and relates to the field of artificial intelligence. The method comprises: obtaining sequencing data of a tissue sample, the sequencing data comprising gene expression data and spatial position data of each sequencing point, and the sequencing point corresponding to at least one cell; generating a gene sequencing matrix of the tissue sample based on the sequencing data, wherein the gene sequencing matrix is used for representing gene distribution conditions at different spatial positions in the tissue sample; based on the gene sequencing matrix, cell function annotation is carried out in a deep learning mode, and a cell function annotation result is obtained. By adopting the scheme provided by the embodiment of the invention, the accuracy of cell function annotation can be improved.

Description

technical field [0001] The embodiments of the present application relate to the field of artificial intelligence, in particular to a cell function annotation method, device, equipment and medium. Background technique [0002] The process of analyzing the transcriptome sequencing data of cells, knowing the gene selective expression of cells from the molecular level, and then classifying cells from the molecular level is called cell function annotation. [0003] In related technologies, before cell function annotation, cells are extracted at multiple spatial locations with the help of high-magnification imaging techniques of tissue samples (such as tissue slice imaging, confocal fluorescence imaging, etc.), and single-cell transcriptome sequencing is performed separately to obtain single-cell Cell space transcriptome data; then the clustering method is used to analyze the single cell space transcriptome data to obtain cell function annotations. [0004] However, since cell fu...

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Application Information

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IPC IPC(8): G16B50/10G16B40/00G16B20/30G16B25/10
CPCG16B50/10G16B40/00G16B20/30G16B25/10
Inventor 沈荣波姚建华
Owner TENCENT TECH (SHENZHEN) CO LTD
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