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Tip-filled electrospray emitter

An emitter, electrospray ionization technology, applied in the field of mass spectrometry, which can solve problems such as reducing chromatographic performance

Pending Publication Date: 2022-05-27
THERMO FINNIGAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This leads to undesired electrochemical processes which reduce chromatographic performance

Method used

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  • Tip-filled electrospray emitter
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  • Tip-filled electrospray emitter

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Embodiment Construction

[0049] Some of the materials described in this disclosure include electrospray ionization (ESI) emitters for mass spectrometers. In one example, a mixture comprising peptides is introduced into a liquid chromatography (LC) system such that the different peptides in the mixture are separated and introduced into a mass spectrometer for analysis at different times. When the peptide is introduced into the mass spectrometer, electrospray ionization (ESI) is used to ionize the peptide and other co-eluting species to generate ions that are transported between the components of the mass spectrometer for mass analysis.

[0050] As described later in this disclosure, tip-filled emitters for ESI may include LC columns coupled to the emitters through post-pillar liquid metal junctions. That is, a tip-filled emitter may contain the integration of an emitter structure with an LC column structure by coupling the two on opposite ends of a post-pillar liquid metal junction to form an assembly ...

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Abstract

A packed-tip electrospray ionization (ESI) emitter for use in mass spectrometry is described. In one aspect, an ESI emitter stores particles of a first type. A liquid chromatography (LC) column is coupled with the emitter by a junction. The LC column stores particles of a different type than the ESI emitter to facilitate better chromatography and ESI performance.

Description

technical field [0001] The present disclosure relates to mass spectrometry, and more particularly to a packedtip electrospray ionization (ESI) emitter for a mass spectrometer. Background technique [0002] The current focus of biological mass spectrometry is the identification, quantification and structural elucidation of peptides, proteins and related molecules. In the context of bottom-up proteomics experiments, proteins are subjected to proteolytic digestion to break down into peptide fragments, which are then typically analyzed by liquid chromatography (LC) prior to introduction into the ion source of a mass spectrometer. to separate. Typically, ion sources used in proteomics experiments implement electrospray ionization (ESI) to ionize peptides to form ions that can be transported between components of a mass spectrometer. [0003] The physical properties of the LC column and ESI emitter can affect analytical performance. For example, the stationary phase chemistry, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/72H01J49/00H01J49/16
CPCG01N30/7266H01J49/004H01J49/0031H01J49/165H01J49/167G01N30/14G01N30/60G01N30/7233G01N33/6848G01N2030/027H01J49/0436
Inventor J·A·塞尔弗拉D·琳德赛斯G·A·舒尔茨M·L·波尔塔什B·H·罗布森
Owner THERMO FINNIGAN