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Deep hydrolyzed infant formula

An infant formula, deep technology, applied in food ingredients, acid-containing food ingredients, functions of food ingredients, etc., can solve problems such as weight gain

Pending Publication Date: 2022-05-27
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, consumption of higher protein infant formula was associated with greater body weight and body mass index at 2 years of age, and higher circulating concentrations of plasma essential amino acids, insulin-like growth factor-1, and C-peptide, which may induce weight gain and lipogenesis active

Method used

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  • Deep hydrolyzed infant formula
  • Deep hydrolyzed infant formula
  • Deep hydrolyzed infant formula

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0186] Example 1 - Illustrative Extensive Hydrolyzed Infant Formula

[0187] The following are illustrative deeply hydrolyzed infant formulas in accordance with the present invention. The eHF of the present invention preferably contains all vitamins and minerals considered to be nutritionally significant amounts necessary for the daily diet. Minimum requirements for certain nutrients, vitamins and minerals have been established.

[0188] Nutrients unit per 100g per 100kcal per 100ml energy kcal 506 100 67 Fat g 26 5.1 3.4 MCT g 0 0 0 available carbohydrates g 57 11 7.5 protein g 11.1 2.2 1.5 2'FL g 0.76 0.15 0.1 LNnT g 0.38 0.075 0.05

Embodiment 2

[0189] Example 2 - Safety and efficacy of deeply hydrolyzed infant formula with reduced protein content.

[0190] Research design

[0191] The safety and efficacy of heavily hydrolyzed infant formula with reduced protein content were studied in a controlled, double-blind, randomized, multicenter, interventional clinical trial in 2 parallel formula feeding groups.

[0192] The main objective of the clinical study was to show that infants with cow's milk protein allergy (CMPA) and fed with the new eHF (Althéra 2.2) with reduced protein levels and with two human milk oligosaccharides (HMOs) (test formulas) compared to those fed the incompatible HMO of commercially available eHF (Althéra 2.5) (control formula) fed infants with consistent growth. Commercially available eHF is approved as food for special medical purposes (Regulation (EU) 2016 / 128). Therefore, the primary study endpoint was daily weight gain from enrollment to 4-month follow-up, with an age window of 0 to 6 mo...

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PUM

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Abstract

The present invention provides a deeply hydrolyzed infant formula (eHF) comprising a protein, a carbohydrate, and a fat wherein the eHF comprises about 2.4 g or less protein per 100 kcal wherein about 30% by weight or less of the fat is a medium chain triglyceride (MCT), and wherein the eHF may further comprise 2 '-fucosyllactose (2' FL) and / or a lactose-N-neotetraose (LNnT).

Description

technical field [0001] The present invention relates to an extensively hydrolyzed infant formula (eHF) comprising reduced amounts of protein. Background technique [0002] Cow's milk protein (CMP) is the leading cause of food allergy in infants, affecting 2%-3% of children worldwide. Most children with CMP allergy (CMPA) have two or more symptoms: 50%-70% have skin symptoms; 50%-60% have gastrointestinal symptoms; and 20%-30% have respiratory symptoms. Serious and life-threatening symptoms may occur in 10% of children. Management of these patients focuses on avoiding CMP and promptly identifying and treating allergic reactions from accidental exposures (Nutten, 2018. EMJ Allergy Immunol, 3(1), pp. 50-59). [0003] Human breast milk and breastfeeding are considered the optimal form of nutrition for healthy babies during the first few months of life. Breast milk remains the gold standard for feeding babies with CMPA. The European Society of Paediatric Gastroenterology, Hep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/00A23L33/18A23L33/115A23L33/125
CPCA23L33/40A23L33/18A23L33/115A23L33/125A23V2002/00A23L33/19A23L33/175A23V2200/304A23V2250/55A23V2250/54252A23V2250/06A23V2250/18A23V2250/612A23V2250/628A23V2250/5114A23V2250/5118A23V2250/28A23L33/12
Inventor M·J·库什利斯P·斯滕豪特A·贾维E·阿克曼
Owner SOC DES PROD NESTLE SA