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Stimulation of neuronal plasticity

A neuron and plasticity technology, applied in nervous system diseases, organic active ingredients, medical preparations containing active ingredients, etc., can solve problems such as memory disturbance enhancement and increased plasticity

Pending Publication Date: 2022-05-27
奥地利科学技术研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current strategy is to completely remove this extracellular matrix in animal models using chondronitase ABC, which also digests PNNs and has been shown to increase plasticity, leading to enhanced memory interference from competing information during the encoding process.

Method used

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  • Stimulation of neuronal plasticity
  • Stimulation of neuronal plasticity
  • Stimulation of neuronal plasticity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0187] method

[0188] animal:

[0189] Male and female adult animals (8-12 weeks) were used. C57BL / 6J (#000664) animals were purchased from The Jackson Laboratories. All animals were housed in the IST Austrian preclinical facility with a 12-hour light-dark cycle and food and water provided ad libitum. All animal procedures were approved by "Bundesministerium für Wissenschaft, Forschung und Wirtschaft (bmwfw) Tierversuchsgesetz 2012, BGBI.I Nr.114 / 2012 (TVG 2012), number GZ BMWF-66.018 / 0001-II / 3b / 2014.

[0190] Drug application:

[0191] C57BL / 6J mice were injected intraperitoneally (i.p.) in the morning. Confirmation of deep anesthesia based on the following parameters:

[0192] 1. No toe pinch reflex for about 10 minutes after induction.

[0193] 2. Reduced breathing rate.

[0194] 3. No response to external stimuli.

[0195] 4. Flaccid paralysis.

[0196] 5. No Beard Exercise.

[0197] To prevent corneal dehydration, use eye ointment (Oleo Vital). During the ...

Embodiment 2

[0262] Example 2 - Effects of Flickering Light Stimulation on Working Memory

[0263] background

[0264] Hole-board discrimination learning in mice to assess spatial working-andreference-memory performance. Genes, Brain and Behavior, 5(4 ): 355-363). The orifice plate apparatus consists of an open field chamber with a 16-well floor insert. Reward particles (also called "bait") were placed in the four wells, and the mice learned the location of these particles throughout the trial. Typically, when completing six trials per day, mice were shown to learn the location of the particles within 4 days. Various data can be collected, such as data related to working memory errors (wells visited), reference memory errors (entering a non-baited hole), and omission errors (leaving a baited hole). Reversal training with new reward particle locations revealed the animals' ability to actively suppress reward-related responses and escape ongoing behaviors.

[0265] method

[0266] an...

Embodiment 3

[0298] Example 3 - Effects of flickering light stimulation on depressive behavior

[0299] In another embodiment, methods such as Burstein and Doron (The Unpredictable ChronicMild Stress Protocol for Inducing Anhedonia in Mice. J. Vis. Exp. (140), e58184, doi: 10.3791 / 58184 (2018)) and Frisbee et al. ( An Unpredictable Chronic Mild StressProtocol for Instigating Depressive Symptoms, Behavioral Changes and NegativeHealth Outcomes in Rodents.J.Vis.Exp.(106),e53109,doi:10.3791 / 53109(2015)) and other protocols described in Exposure to Unpredictable Chronic Mild Stress (UCMS). Mice exposed to UCMS often exhibited depressive-like behavioral phenotypes such as changes in physical activity, increased anxiety, decreased responsiveness to reward (anhedonia), and elevated corticosteroid levels. Consequently, UCMS mice exhibited increased anxiety-related behaviors in the elevated plus maze, significantly increased corticosteroid levels, and required more time (and produced more errors) d...

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Abstract

Described herein are methods, devices, and systems for stimulating neural oscillations at high gamma wave frequencies, in particular for facilitating neuronal plasticity and removal of neuronal surrounding networks. Such methods, devices, and systems may be used to treat neuropsychiatric disorders, such as schizophrenia and depression, in a subject in need thereof.

Description

[0001] Field of Invention [0002] The present invention relates to promoting plasticity of the central nervous system, especially the brain. Specifically, the present invention relates to the promotion of neuronal plasticity by removing the perineuronal net. The present invention may be particularly useful in the treatment of conditions and diseases in which it is desired to promote neuronal plasticity and / or remove or reduce peri-neuronal networks. Such conditions include those in which neuronal connections are damaged, such as depression and schizophrenia, as well as spinal cord injuries. [0003] Background of the Invention [0004] Ketamine is a potent anesthetic and analgesic with significant effects on GABAergic inhibitory neurons. It is a dissociative drug widely used in anesthesia, analgesia, sedation, and the treatment of psychiatric symptoms (Krystal, J.H. et al (2019) Neuron 101 (5): 774-778; Li, L. & Vlisides, P.E. (2016) Front. Hum. Neurosci. 10 : 612; Zanos, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M21/00A61K45/00A61K31/137A61P25/18A61P25/22A61P25/24
CPCA61K45/00A61K31/137A61P25/22A61P25/24A61P25/18A61M21/00A61M2021/0044A61M2021/0027A61K31/135A61N5/0622A61N2005/0652A61N5/0618A61N2005/0626A61N2005/0648A61P25/28A61K31/138A61K31/343A61K31/4525A61K31/48A61K31/496A61K31/5513A61K31/554A61K31/675A61K41/00
Inventor A·文图里诺S·西格特
Owner 奥地利科学技术研究所
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