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Sodium hyaluronate gel lubricating liquid, filling agent and preparation method and application of sodium hyaluronate gel lubricating liquid and filling agent

A technology of sodium hyaluronate and lubricating fluid, which is used in pharmaceutical formulations, prostheses, drug delivery, etc., to simplify the preparation process, facilitate injection, and reduce pushing force.

Inactive Publication Date: 2022-06-10
ZHEJIANG JINGJIA MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention is to overcome the short duration of the filling effect of sodium hyaluronate gel in the prior art, and the defect that the duration of the filling effect is uncontrollable at the same time, provides a A kind of sodium hyaluronate gel lubricating liquid, filler and its preparation method and application

Method used

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  • Sodium hyaluronate gel lubricating liquid, filling agent and preparation method and application of sodium hyaluronate gel lubricating liquid and filling agent
  • Sodium hyaluronate gel lubricating liquid, filling agent and preparation method and application of sodium hyaluronate gel lubricating liquid and filling agent
  • Sodium hyaluronate gel lubricating liquid, filling agent and preparation method and application of sodium hyaluronate gel lubricating liquid and filling agent

Examples

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Effect test

preparation example Construction

[0055] The compounding comprises the following steps: uniformly centrifuging and mixing the sodium hyaluronate gel particles and the lubricating liquid at a centrifugal speed of 5000 rpm to obtain the sodium hyaluronate gel filler.

[0056] The sodium hyaluronate gel fillers prepared from the lubricating solutions in Examples 1-10 and Comparative Examples 1-5 were tested.

[0057] 【test analysis】

[0058] 【Test Results】

[0059] Table 2

[0060] 2. Polycaprolactone homogeneity test

[0061] The calculation formula for calculating the population standard deviation is as follows: .

Embodiment 1

Embodiment 2

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PUM

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Abstract

The invention relates to the field of cosmetic filling materials, in particular to a sodium hyaluronate gel lubricating liquid, a filling agent and a preparation method and application thereof.The sodium hyaluronate gel lubricating liquid comprises a sodium hyaluronate solution, polycaprolactone microspheres are evenly dispersed in the sodium hyaluronate solution, alkali liquor is added into the polycaprolactone microspheres and sodium hyaluronate dry powder, and the sodium hyaluronate gel lubricating liquid is obtained. According to the sodium hyaluronate gel, the polycaprolactone microspheres and the sodium hyaluronate solution are matched, so that the concentration of the polycaprolactone microspheres which are finally injected into the sodium hyaluronate gel of a human body is controllable and can be always kept consistent, and the sodium hyaluronate gel can be used for preparing the sodium hyaluronate gel. Therefore, the continuous time and the continuous stability of the filling effect in the human body can be kept, and meanwhile, the pushing force in the injection process can be reduced on the premise of keeping a good injection effect, so that the injection can be more easily injected into the human body.

Description

technical field [0001] The invention relates to the field of cosmetic filling materials, in particular to a sodium hyaluronate gel lubricating liquid, a filling agent and a preparation method and application thereof. Background technique [0002] Sodium hyaluronate products have been widely used in facial injections to improve facial congenital or acquired depressions, scar depressions, fine lines, stubborn wrinkles and other problems. Cross-linked sodium hyaluronate has a short degradation cycle, generally 6-12 months, its degradation cycle in the body is too short to achieve long-term effects. [0003] Polycaprolactone is a polymer that can be completely absorbed by the human body. It is now commonly used in medical devices such as surgical sutures and orthopedic implants. Its degradation time is much longer than that of sodium hyaluronate. Therefore, there are some in the prior art. The technical solution is to compound polycaprolactone and sodium hyaluronate gel to achi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/18A61L27/50A61L27/58C08J3/12C08L67/04
CPCC08J3/12A61L27/20A61L27/18A61L27/50A61L27/58C08J2367/04A61L2400/06A61L2300/452A61L2300/802C08L5/08C08L67/04
Inventor 陈强张珺
Owner ZHEJIANG JINGJIA MEDICAL TECH CO LTD
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