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Equipment for producing liquid composition as well as preparation method and application thereof

A liquid composition and equipment technology, applied in the directions of organic chemistry methods, chemical instruments and methods, introduction of isotopes into organic compounds, etc., can solve the problems of inability to prepare compound I liquid composition, no radiation protection, limited clinical use, etc.

Active Publication Date: 2022-07-08
BEIJING SINOTAU INT PHARMA TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, it is not possible to prepare a large amount of compound Ⅰ liquid composition (such as injection) in a non-automatic production mode without complete radiation protection and manual labeling. A single preparation can only be used by 1~2 people, and the clinical use is limited.

Method used

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  • Equipment for producing liquid composition as well as preparation method and application thereof
  • Equipment for producing liquid composition as well as preparation method and application thereof
  • Equipment for producing liquid composition as well as preparation method and application thereof

Examples

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Embodiment Construction

[0087] The following embodiments of the present application are only used to illustrate specific embodiments for realizing the present application, and these embodiments should not be construed as limitations on the present application. Any other changes, modifications, substitutions, combinations and simplifications made without departing from the spirit and principle of this application are regarded as equivalent substitution methods and fall within the protection scope of this application.

[0088] This example provides a method for producing 2-tert-butyl-4-chloro-5-((3-((4-((2-(2-fluoro[ 18 F]Ethoxy)ethoxy)methyl)-1 H -1,2,3-Triazol-1-yl)methyl)benzyl)oxy)pyridazine-3(2 H )-ketone (hereinafter referred to as "compound I") liquid composition (such as injection) equipment, including:

[0089] Preprocessing module for enrichment 18 F ion;

[0090] Reaction module for enriched 18 The F ion reacts with the precursor of compound I to obtain the crude product of compound I; ...

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Abstract

The invention provides equipment for producing a liquid composition of 2-tert-butyl-4-chloro-5-((3-((4-((2-(2-fluoro [18F] ethyoxyl) ethyoxyl) methyl)-1H-1, 2, 3-triazole-1-yl) methyl) benzyl) oxygen) pyridazine-3 (2H)-one (hereinafter referred to as' Compound I '), comprising: a pretreatment module for enriching < 18 > F ions; the reaction module is used for reacting the enriched < 18 > F ions with a compound I precursor to obtain a compound I crude product; the purification module is used for purifying the compound I crude product to obtain a compound I pure product; and the prescription module is used for enriching and formulating the purified compound I pure product into a compound I liquid composition. The liquid composition of the compound I prepared by the equipment provided by the invention can be directly used clinically. The invention also provides a method for preparing the compound I liquid composition by the equipment and application of the equipment in preparation of the compound I liquid composition.

Description

technical field [0001] The present application relates to the technical field of radiopharmaceuticals, in particular to equipment for producing liquid compositions, and preparation methods and uses thereof. Background technique [0002] Coronary heart disease is one of the most serious diseases that threaten human health. In my country, both the morbidity and mortality of coronary heart disease are on the rise. In 2007, the data released by the Ministry of Health showed that about 3 million people died of cardiovascular disease every year in my country, which has become the first cause of death in my country's urban and rural populations, accounting for nearly 40% of the causes of death in my country. [0003] Myocardial perfusion imaging (MPI) single photon emission computed tomography (SPECT) imaging technology is currently the main clinical method for noninvasive perfusion imaging for coronary heart disease detection and prognosis evaluation. However, compared with SPEC...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D403/12C07B59/00
CPCC07D403/12C07B59/002C07B2200/05
Inventor 王跃张颖张爱丽徐新盛
Owner BEIJING SINOTAU INT PHARMA TECH CO LTD
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