Soluble polymer eye insert with biodegradable polymer
A biodegradable polymer technology, applied in the direction of drug combinations, organic active ingredients, medical preparations of non-active ingredients, etc., can solve problems such as slow dissolution properties, irritation or congestion, blurred vision, etc.
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example 1
[0050] Example 1 - Polymeric Eye Inserts Containing Alpha-2-Adrenergic Agonists
[0051] In other inventions, alpha-2 adrenergic receptor agonists such as brimonidine were used to prepare intercalated membranes at different concentrations, namely 90 ppm, 495 ppm and 5048 ppm, respectively.
[0052] Prepare control insert membrane_brimonidine:
[0053] Transfer 300 mL of DI water from the graduated cylinder to a clean 500 mL Erlenmeyer flask. HA (0.94 g) and PVP (0.21 g) were added to a 500 ml Erlenmeyer flask. stir the mixture
[0054] After 1.5 hours, a homogeneous solution was obtained. Add HP Guar Gum (0.84g) and
[0055] The mixture was stirred for 1 hour, making the mixture homogeneous again. PEG (0.21 g) was added and the mixture was stirred for an additional 30 min. The mixture is then allowed to sit
[0056] (without stirring) for 30 min to remove air bubbles. Pour the mixture (150g) into a petri dish,
[0057] The dishes were then placed in an evaporation ove...
example 2
[0076] Example 2 - Polymer Eye Inserts Containing PLGA
[0077] The addition of PLGA (MW: 10,000 to 18,000 and 96,000) to polymer insert compositions at different concentrations (1%, 1.7%, 2% and 4%) was evaluated. The PLGA doped film exhibited a similar spectrum to the undoped film. The presence of PLGA slowed the dissolution rate without significantly changing the mechanical properties of the membrane. The concentration and molecular weight of PLGA had obvious effects on the dissolution profile.
[0078] PLGA solubility screening:
[0079] Both low or high MW PLGA were found to be insoluble in DI water, ethanol, amyl alcohol, methanol and PEG 400. Low or high MW PLGA was found to be soluble in DCM, THF, EA and acetone. Either low or high MW PLGA will be introduced into the current formulation as a solution in acetone.
[0080] Prepare control insert membrane_PLGA:
[0081] Transfer 300 mL of DI water from the graduated cylinder to a clean 500 mL Erlenmeyer flask. HA (...
example 11
[0105] Example 11 - Polymeric Eye Insert Containing TRPM8 Agonist (Mentone Glycerol Ketal)
[0106] The addition of MGA to the polymer insert composition was evaluated at 20 ppm and 40 ppm. The MGA doped films exhibited similar color and transparency to the undoped films. The presence of MGA significantly altered the folding durability results. After less than 20 folding cycles, the MGA-doped dry films exhibited cracks / breaks. In contrast, both doped and undoped hydrated films exhibited similar folding durability properties.
[0107] Prepare control insert membrane_MGA:
[0108] Transfer 800ml of DI water from the graduated cylinder to a clean 1000ml Erlenmeyer flask. HA (2.24g) and PVP (0.56g) were added to a 1000ml Erlenmeyer flask. The mixture was stirred by mechanical stirring and sonicated at the same time. After a total of 1.5 hours, the mixture was observed to appear homogeneous. HP guar gum (2.24 g) was added and the mixture was stirred again while being sonicat...
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