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Use of lone peptide for treating ketamine addiction

A technology of ketamine and orphan, which is applied in the field of biomedicine to achieve the effect of significant drug effect and recovery of physiological functions

Pending Publication Date: 2022-07-29
NINGXIA QIPEPTIDE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, no studies have verified that orphanin can be used in the treatment of ketamine addiction by intrathecal administration

Method used

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  • Use of lone peptide for treating ketamine addiction
  • Use of lone peptide for treating ketamine addiction
  • Use of lone peptide for treating ketamine addiction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Single low dose administration

[0035] A rhesus monkey model of ketamine addiction was established by the following methods:

[0036] The rhesus monkeys were reared alone, provided 3 times a day with adequate monkey feed and 2 times of fruit, free drinking water, and intramuscularly injected ketamine hydrochloride injection to establish a ketamine-addicted rhesus monkey model, including the following steps:

[0037] (a) Dosing period in acute modeling stage: 14 consecutive days, twice a day, each time at a constant dose of 8 mg / kg body weight, intramuscularly inject ketamine hydrochloride injection into rhesus monkeys;

[0038] (b) Transition period of acute modeling stage: on the following day, according to the dose of step (a), intramuscular injection of ketamine hydrochloride injection was given to rhesus monkeys in the morning, and an equal volume of normal saline was intramuscularly injected into rhesus monkeys in the afternoon;

[0039] (c) Forced with...

Embodiment 2

[0069] Example 2 Single high-dose administration

[0070] Three ketamine-addicted rhesus monkey models were randomly divided into 2 groups after modeling, among which: 2 rhesus monkeys in the experimental group were numbered 1 and 2; 1 rhesus monkey in the model group. All rhesus monkeys were housed individually, provided with sufficient monkey feed and 2 times of fruit daily, and had free access to water.

[0071]The experimental group was given orphan at a dose of 5 mg / kg, dissolved with 500 μl of normal saline for injection and then injected intrathecally. The model group was given an equal volume of normal saline for injection.

[0072] All rhesus monkeys were tested for behavior, cortisol (CRF) concentration and orphanin concentration before and after administration of orphan or normal saline. This behavioral test can directly observe the degree of addiction of rhesus monkeys. This plasma cortisol concentration test can evaluate whether orphanin has the potential to res...

Embodiment 3

[0078] Example 3 Continuous low-dose administration

[0079] The three ketamine-addicted rhesus monkey models in Example 2 were constructed as stable ketamine-addiction models again after a 3-month recovery period, and the grouping settings in Example 2 were repeated after modeling. The 3 ketamine-addicted rhesus monkeys were divided into 2 groups, wherein: 2 rhesus monkeys in the experimental group maintained the numbers 1 and 2 in Example 2; 1 rhesus monkey in the model group. All rhesus monkeys were housed individually, provided with sufficient monkey feed and 2 times of fruit daily, and had free access to water.

[0080] The experimental group was given orphan at a dose of 0.5 mg / kg, dissolved with 500 μl of normal saline for injection and then injected intrathecally, while the model group was given an equal volume of normal saline for injection. The dosing interval was 7 days, and the patients were administered 4 times, respectively on the 0th day, the 7th day, the 14th ...

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Abstract

According to the invention, a non-human primate ketamine addiction model is adopted to deliver an effective dose of the ketamine peptide to the central nervous system in the brain through cerebrospinal fluid circulation in an intrathecal administration manner to enhance the self-management of the medicine of rhesus monkeys, which proves that the ketamine peptide has a remarkable inhibition effect on the forcing foraging behavior of ketamine; the ketamine addiction inhibitor can quickly and effectively solve the problem that the expression quantity of the ketamine in the brain is reduced due to the ketamine addiction, the ketamine enters the brain through intrathecal administration, the negative emotions such as impatience and irritability caused by forced withdrawal of the ketamine can be relieved, the medication desire is reduced, meanwhile, the function of the hypothalamus-pituitary-adrenal gland (HPA) axis is recovered, and the ketamine addiction inhibitor can be used for treating the ketamine addiction.

Description

technical field [0001] The present invention belongs to the field of biomedicine, and in particular, the present invention relates to orphans for treating ketamine addiction. Background technique [0002] At present, new synthetic drugs are increasingly widespread and harmful, and there is no effective drug for drug treatment and rehabilitation in clinical practice. Ketamine (KET), as a new type of drug K powder, has entered the public eye. Ketamine can quickly cross the blood-brain barrier with blood circulation to stimulate the brain to produce a strong euphoria and has hallucinogenic effects. The abuse of ketamine can cause serious physical damage and psychological dependence. The low price, strong irritation and addictive properties make ketamine the "first milk" for criminals to lure victims into the drug. Forced ketamine withdrawal can lead to a strong craving for relapse in drug users, resulting in dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/10A61K45/06A61P25/36A61K31/137A61K31/55
CPCA61K38/10A61K45/06A61K31/137A61K31/55A61P25/36A61K2300/00
Inventor 秦蒙石哲袁逖飞
Owner NINGXIA QIPEPTIDE TECH CO LTD