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Emodin methyl ether microemulsion and application thereof

A technology of emodin methyl ether and microemulsion, which is applied in the field of agricultural biology to achieve the effect of promoting healthy development

Pending Publication Date: 2022-08-02
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Emodin methyl ether has been reported in the literature and patented technology, which is mainly limited to the field of pesticides. How to solve the water solubility of emodin methyl ether and use it in animal husbandry to replace antibiotics still has many technical problems

Method used

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  • Emodin methyl ether microemulsion and application thereof
  • Emodin methyl ether microemulsion and application thereof
  • Emodin methyl ether microemulsion and application thereof

Examples

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preparation example Construction

[0030] The invention aims to provide a preparation method of emodin methyl ether microemulsion and its application in preventing and treating diseases caused by drug-resistant bacteria in livestock and poultry.

[0031] The emodin methyl ether microemulsion (emodin methyl ether microemulsion preparation or emodin methyl ether microemulsion) is a microemulsion system composed of an organic solvent and a surfactant. The preferred microemulsion system formulation includes one or more of N,N-dimethylformamide or N,N-dimethylacetamide, ethanol or Tween-20.

[0032] Preferably, the 10% emodin methyl ether microemulsion is made of N,N-dimethylformamide or N,N-dimethylacetamide, absolute ethanol, Tween-20 and water in a volume ratio of 25: The system of 10:1:14 is formulated.

[0033] The administration mode of emodin methyl ether is oral administration, injection, aerosol administration, perfusion (breast perfusion, uterine perfusion).

[0034] The invention also provides the appli...

Embodiment 1

[0041] The preparation of embodiment 1 emodin methyl ether microemulsion

[0042] 1. Composition: Emodin methyl ether 10g, N,N-dimethylformamide or N,N-dimethylacetamide 20ml, 75% ethanol 30ml, add water to 100ml.

[0043] 2. Preparation method:

[0044] 2.1 Weigh the raw and auxiliary materials according to the prescription amount and set aside.

[0045] 2.2 Dissolve emodin methyl ether in N,N-dimethylformamide or N,N-dimethylacetamide, then add 75% ethanol and Tween-20, and after mixing, slowly add water to make up to 100ml.

[0046] 3. Result: The prepared microemulsion was brown, 50% dissolved, and precipitate appeared after standing.

Embodiment 2

[0047] The preparation of embodiment 2 emodin methyl ether microemulsion

[0048] 1. Composition: Emodin methyl ether 10g, N,N-dimethylformamide or N,N-dimethylacetamide 20ml, 95% ethanol 30ml, add water to 100ml.

[0049] 2. Preparation method:

[0050] 2.1 Weigh the raw and auxiliary materials according to the prescription amount and set aside.

[0051] 2.2 Dissolve emodin methyl ether in N,N-dimethylformamide or N,N-dimethylacetamide, then add 95% ethanol, and after mixing, slowly add water to make up to 100ml.

[0052] 3. Result: The prepared microemulsion was brown, 60% dissolved, and precipitate appeared after standing.

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Abstract

The invention discloses an emodin methyl ether microemulsion and an application thereof. The emodin methyl ether microemulsion is a microemulsion system composed of an organic solvent and a surfactant. Preferably, the formula of the microemulsion system comprises one or more of N, N-dimethylformamide or N, N-dimethylacetamide, ethanol or Tween-20. In-vitro experiments prove that the physcion can be used for killing clinical drug-resistant bacillus cereus, enterococcus faecalis, bacillus gallisepticum, ornithobacterium rhinotracheitis, haemophilus paragallinarum, klebsiella, chlamydia psittaci, mycoplasma gallisepticum and mycoplasma synoviae. Meanwhile, animal experiments prove that the emodin methyl ether microemulsion is suitable for preventing and treating respiratory tract diseases caused by avian rhinotracheitis, haemophilus paragallinarum, klebsiella, chlamydia psittaci and mycoplasma gallisepticum clinically, liver rupture caused by bacillus cereus, enterococcus faecalis and chicken bacilli, and the like. The bovine mastitis and endometritis caused by klebsiella and bacillus cereus can be treated.

Description

technical field [0001] The invention belongs to the field of agricultural biotechnology, in particular to an emodin methyl ether microemulsion and its application. Background technique [0002] Emodin methyl ether (Physcion), the structure is shown in formula I, anthraquinone compound, CAS registration number is 521-61-9. [0003] Chemical name: 1,8-dihydroxy-3-methoxy-6-methylanthraquinone, molecular formula is C 16 H 12 O 5 , molecular weight 284.26. [0004] [0005] Pure product is yellow needle crystal; Melting point: 203℃~207℃; Vapor pressure (20~25℃): 4.8×10 -11 Pa; Solubility: soluble in benzene, chloroform, pyridine, toluene, slightly soluble in acetic acid and ethyl acetate, insoluble in methanol, ether, acetone, a small amount of emodin methyl ether can slowly dissolve in ethanol and water. Hydrolysis under strong acid conditions and slow photolysis under strong UV light. [0006] Emodin methyl ether is a botanical pesticide extracted from the roots and s...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/122A61K47/10A61K47/18A61K47/26A61P1/00A61P11/00A61P15/00A61P15/14A61P31/04A61P1/16
CPCA61K31/122A61K9/1075A61K9/0053A61K9/0019A61K9/0034A61K9/0041A61K47/18A61K47/26A61K47/10A61P31/04A61P11/00A61P1/00A61P15/14A61P15/00A61P1/16Y02A40/70
Inventor 何诚刘心怡陈家琪刘佳琪宫启翔谭丽萍何润春
Owner CHINA AGRI UNIV
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