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Purification preparation method of refined nicotine

A nicotine and high-quality technology, applied in the field of tobacco chemistry, can solve the problems of high energy consumption and low product purity, and achieve the effects of reducing ammonium salt content, high purity, and convenient industrial production

Pending Publication Date: 2022-08-05
云南叶贵生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies of the prior art, the present invention provides a purification and preparation method of high-quality nicotine with a simple and reasonable process, which solves the problems of high energy consumption and low product purity in the existing distillation method

Method used

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  • Purification preparation method of refined nicotine

Examples

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Effect test

Embodiment 1

[0023] A kind of purification preparation method of fine nicotine, such as figure 1 shown, including the following steps:

[0024] S1), the crude product nicotine of purity 40% is deacidified with 30% sodium hydroxide solution, stir, adjust pH≤13, leave standstill for 1 hour, crude product nicotine and sodium hydroxide solution mass ratio are 1:1, the solution The temperature is maintained at 77°C;

[0025] S2), leave standstill and wait for layering, after layering finishes, get supernatant nicotinic lye and send it into the distiller, and the subnatant is then recycled to the storage tank, and the subnatant is extracted by No. 6 solvent oil, and after the extraction is concentrated Obtain crude nicotine.

[0026] S3), carry out macromolecular distillation to the nicotine liquid in the distiller, and the distillation reaction time is 3 hours. The rectification process includes: at 0.05MPa, the distillation temperature is 100-115°C, and water and light yellow miscellaneous ...

Embodiment 2

[0030] A kind of purification preparation method of fine nicotine, such as figure 1 shown, including the following steps:

[0031] S1), the crude product nicotine of purity 40% is deacidified with 35% sodium hydroxide solution, stir, adjust pH≤13, leave standstill for 1 hour, crude product nicotine and sodium hydroxide solution mass ratio are 1:2, the solution The temperature is maintained at 75°C;

[0032] S2), leave standstill and wait for layering, after layering finishes, get supernatant nicotinic lye and send it into the distiller, and the subnatant is then recycled to the storage tank, and the subnatant is extracted by No. 6 solvent oil, and after the extraction is concentrated Obtain crude nicotine.

[0033] S3), carry out polymer distillation to the nicotinic lye liquid in the distiller, and the distillation reaction time is 4 hours. The process of rectification includes: at 0.05MPa, the distillation temperature is at 90-105°C, and water and light yellow miscellaneo...

Embodiment 3

[0037] A kind of purification preparation method of fine nicotine, such as figure 1 shown, including the following steps:

[0038] S1), the crude product nicotine of purity 40% is deacidified with 25~35% sodium hydroxide solution, stir, adjust pH≤13, leave standstill for 1 hour, crude product nicotine and sodium hydroxide solution mass ratio is 1:4 , the solution temperature was maintained at 80 °C;

[0039] S2), leave standstill and wait for layering, after layering finishes, get supernatant nicotinic lye and send it into the distiller, and the subnatant is then recycled to the storage tank, and the subnatant is extracted by No. 6 solvent oil, and after the extraction is concentrated Obtain crude nicotine.

[0040] S3), carry out macromolecular distillation to the nicotine liquid in the distiller, and the distillation reaction time is 2 hours. The process of rectification includes: at 0.05MPa, the distillation temperature is 70~105℃, water and light yellow miscellaneous al...

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Abstract

The invention relates to the technical field of tobacco chemistry, in particular to a purification preparation method of refined nicotine. The purification preparation method of the refined nicotine comprises the following steps: S1, deacidifying crude nicotine with the purity of 40% by using a 25-35% sodium hydroxide solution, uniformly stirring, adjusting the pH value to be less than or equal to 13, and standing for 1 hour; s2, standing to wait for layering, after layering is finished, feeding supernatant smoke alkali liquor into a distiller, and recycling lower clear liquor into a storage tank for cyclic utilization; s3, carrying out polymer distillation on the nicotine liquor in the distiller, and carrying out rectification and purification under the conditions that the temperature is 140-170 DEG C and the vacuum degree is 0.07 MPa to obtain refined nicotine with the purity being greater than or equal to 99.5%; and S4, under the condition of nitrogen protection, loading into a brown container subjected to sterilization and drying treatment, and storing in an environment of 0-4 DEG C. The invention provides a purification preparation method of refined nicotine, and solves the problems of high energy consumption and low product purity in the existing distillation method.

Description

technical field [0001] The invention relates to the technical field of tobacco chemistry, in particular to a method for purifying and preparing fine nicotine. Background technique [0002] Nicotine, also known as nicotine, is an important pharmaceutical and chemical raw material. It is expected to become an effective drug for the treatment of Alzheimer's disease, Parkinson's disease and depression, and its demand is large. Nicotine is divided into crude products and fine products, wherein the purity of crude nicotine is generally 40%, which is mainly used to prepare botanical pesticides or as raw materials for purification of fine nicotine. The purity of fine nicotine is between 98% and 99%, most of which are used in the preparation of electronic cigarette oil, and also used in the production of electronic cigarette cartridges. [0003] Nicotine is mainly extracted from tobacco or tobacco stems and leaves discarded from tobacco manufacturing. At present, the preparation of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/04
CPCC07D401/04
Inventor 张钧童
Owner 云南叶贵生物科技有限公司
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