Drug composition containing cefazolin and beta-lactamase inhibitor
A technology of lactamase and cefazolin is applied in the directions of medical preparations containing active ingredients, active ingredients of heterocyclic compounds, antibacterial drugs, etc., to prevent resistance, slow down the development of drug resistance, and expand the scope of clinical application. Effect
Inactive Publication Date: 2004-11-24
YOUCARE PHARMA GROUP +1
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- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
But so far, no one has studied cefazolin in combination with clavulanic acid or tazobactam
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0054] Example 1: Mix 250 mg of cefazolin and 250 mg of clavulanic acid thoroughly, and operate according to the powder injection preparation process procedure.
Embodiment 2
[0055] Example 2: Mix 250 mg of cefazolin and 125 mg of clavulanic acid thoroughly, and operate according to the powder injection preparation process procedure.
Embodiment 3
[0056] Example 3: Mix 250 mg of cefazolin and 62.5 mg of clavulanic acid thoroughly, and operate according to the powder injection preparation process procedure.
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An antibacterial composite medicine contains ancef or its salt and beta-lactamase inhibitor (tazobactam or clavulanic acid) in Wt ratio of (1-20):(1-5). Its advnatage is high synergistic antibacterial action.
Description
field of invention [0001] The present invention relates to a synergistic antibacterial pharmaceutical composition. Specifically, the pharmaceutical composition contains cefazolin and a β-lactamase inhibitor (tazobactam, clavulanic acid or a pharmaceutically acceptable salt thereof). It also relates to a method for preparing the pharmaceutical composition and the use of cefazolin and a β-lactamase inhibitor in the preparation of medicines for treating infectious diseases. Background of the invention [0002] Cefazolin is a known β-lactam antibiotic. The pharmacokinetic properties of this product are superior: high plasma protein binding rate, low distribution volume, and slow excretion rate, so the serum concentration is high and long-lasting. The treatment of diseases is often better than other first-generation cephalosporins, so it is widely used clinically. However, some data suggest that due to the instability of cefazolin to β-lactamase, some strains of Staphylococcus ...
Claims
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IPC IPC(8): A61K31/43A61K31/546A61P31/04
Inventor 金描真白云
Owner YOUCARE PHARMA GROUP
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