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Shuanghuanglian effervescence tablet and its preparation

A technology of Shuanghuanglian and effervescent tablets, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, and drug delivery, etc., can solve problems such as waste of resources and low extraction rate of active ingredients.

Inactive Publication Date: 2005-12-28
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, Shuanghuanglian preparations are extracted by decoction pieces or native medicines (Chinese Pharmacopoeia 2000 edition one, Shuanghuanglian oral liquid, Shuanghuanglian granules, Shuanghuanglian suppository), which have the disadvantages of low extraction rate of active ingredients and waste of resources. It is extracted after pulverization by micro-pulverization equipment, which has the characteristics of complete dissolution of active ingredients and high extraction efficiency.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1. Prescription Honeysuckle 750g, Scutellaria baicalensis 750g, Forsythia 1500g

[0016] Take the prescribed amount of medicinal materials, dry them at low temperature, pulverize them with a Bailey micro-powder machine, and set aside. Take Scutellaria baicalensis powder, add water and decoct three times, the first time for 2 hours, the second and third times for 1 hour each, combine the decoction, filter, concentrate the filtrate to an appropriate amount, add 2mol / L hydrochloric acid solution to the concentrated solution at 80°C, and adjust the pH value to 1.0-2.0, keep warm for 1 hour and then stand for 24 hours, filter, add 6-8 times the amount of water to the precipitate, adjust the pH value to 7.0-7.5 with 40% sodium hydroxide solution, add the same amount of ethanol, stir to dissolve , filtered. The filtrate was adjusted to pH 2.0 with 2mol / L hydrochloric acid solution, kept at 60°C for 30 minutes, allowed to stand for 12 hours, filtered, and the precipitate was w...

Embodiment 2

[0018] 1. Prescription Honeysuckle 750g, Scutellaria baicalensis 750g, Forsythia 1500g

[0019] Take the prescribed amount of medicinal materials, dry them at low temperature, pulverize them with a Bailey micro-powder machine, and set aside. Take Scutellaria baicalensis powder, add water and decoct three times, the first time for 2 hours, the second and third times for 1 hour each, combine the decoction, filter, concentrate the filtrate to an appropriate amount, add 2mol / L hydrochloric acid solution to the concentrated solution at 80°C, and adjust the pH value to 1.0-2.0, keep warm for 1 hour and then stand for 24 hours, filter, add 6-8 times the amount of water to the precipitate, adjust the pH value to 7.0-7.5 with 40% sodium hydroxide solution, add the same amount of ethanol, stir to dissolve , filtered. The filtrate was adjusted to pH 2.0 with 2mol / L hydrochloric acid solution, kept at 60°C for 30 minutes, allowed to stand for 12 hours, filtered, and the precipitate was w...

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PUM

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Abstract

The invention relates to a Shuanghuanglian effervescent tablet and a preparation method thereof. The effervescent tablet is composed of Shuanghuanglian extract powder, disintegrant, lubricant and sweetener. Good stability. The Shuanghuanglian effervescent tablet of the invention has the characteristics of good stability, high content of active ingredients, good taste, convenient taking and high bioavailability. Pharmacological experiments show that the antipyretic and anti-inflammatory effects of the Shuanghuanglian hot effervescent tablet are stronger than those of the Shuanghuanglian oral liquid.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and more specifically relates to a Shuanghuanglian effervescent tablet and a preparation method thereof. Background technique [0002] Influenza is clinically common disease, frequently-occurring disease, mainly shows as symptoms such as heating, cough, sore throat. The disease incidence rate is high, and the drug demand is large. The traditional Chinese medicine Shuanghuanglian Oral Liquid is composed of honeysuckle, scutellaria baicalensis and forsythia. At present, its dosage forms mainly include Shuanghuanglian oral liquid, Shuanghuanglian tablet, Shuanghuanglian freeze-dried powder injection, Shuanghuanglian injection, Shuanghuanglian aerosol, Shuanghuanglian buccal tablet, Shuanghuanglian suppository, Shuanghuanglian granule, etc., but currently There is no effervescent tablet formulation yet, and in view of its remarkable clinical efficacy, it is planned to be changed...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K9/46A61P11/04A61P11/14A61P31/00
Inventor 张晴龙
Owner 张晴龙