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Method and apparatus for making measurements of accumulations of magnetic particles

A technology of magnetic particles and particles, applied in the field of detecting the existence of magnetic particles, can solve complex problems

Inactive Publication Date: 2006-07-19
QUANTUM DESIGN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The SQUID's complexity and cryogenic parts make it unsuitable for use in inexpensive bench tools
Even designs based on so-called "high temperature" superconductors cannot completely overcome these disadvantages and introduce several new difficulties (see Fujiwara et al. patent)

Method used

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  • Method and apparatus for making measurements of accumulations of magnetic particles
  • Method and apparatus for making measurements of accumulations of magnetic particles
  • Method and apparatus for making measurements of accumulations of magnetic particles

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Experimental program
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Embodiment Construction

[0054] Reference is now made to the drawings, and more particularly to Figures 1 and 3 therein. A preferred embodiment of the invention is shown in the drawing.

[0055] I. Reader Assembly

[0056] The reader assembly consists of several different subsystems. These subsystems include a sample holder with motion control in which a sample of a magnetic bond composite for measurement is placed, allowing the necessary relative movement within the system; A magnetizer or magnetic field source applies the excitation signal to the sample; a sensor such as a detection coil acts as a signal sensor for the signal generated in the sample; an excitation circuit supplies excitation current to the coil of the magnetic field source; an amplifier / phase detection A converter / digitizer is connected to the sensor to receive and process the output signal; a microcomputer chip provides two-way communication between an external personal computer (PC) and the reader assembly.

[0057] A. Sample M...

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Abstract

An apparatus is provided for quantitatively measuring combinations of magnetic particles combined with analytes whose amount or other characteristic quality is to be determined. The magnetic particles are complexed with the analytes to be determined and are excited in a magnetic field. The magnetizations of the magnetic particles are thereby caused to oscillate at the excitation frequency in the manner of a dipole to create their own fields. These fields are inductively coupled to at least one sensor such as sensing coils fabricated in a gradiometer configuration. The output signals from the sensing coils are appropriately amplified and processed to provide useful output indications.

Description

technical field [0001] The present invention relates generally to detecting the presence of magnetic particles, and more particularly to the quantitative measurement of such particles using magnetic excitation of alternating current and inductive detection of the amplitude of vibration of the particle's magnetic moment at the excitation frequency. accumulation. Background technique [0002] Much attention has been paid to methods for determining the presence, eg, concentration levels, of small particles in larger mixtures or solutions in which particles are present. In some cases it is desirable to measure very low concentrations of certain organic compounds. For example, in medicine, it is very useful to determine the concentration of a given molecule, usually in solution. Such molecules are either naturally present in physiological fluids (eg blood or urine) or have been introduced into existing systems (eg drugs or pollutants). [0003] A widely used method for detecti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/72G01R33/12G01N33/483G01N33/487G01N33/543G01N33/553G01N35/00
CPCY10S977/838B82Y25/00G01N27/745B82Y15/00Y10S977/96Y10S977/773G01R33/12G01N35/0098
Inventor M·B·西蒙兹K·G·詹森J·H·迪德里赫斯R·C·布莱克
Owner QUANTUM DESIGN