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428results about How to "Achieve change" patented technology

Nasal Dilation Method And Device

InactiveUS20120067345A1Increasing respiratory efficiencyIncreasing inspiratoryRespiratorsBreathing masksFacial skinBiomedical engineering
A nasal dilator adapted to stretch facial skin, including a resilient layer and attachment means. The resilient layer has an equilibrium configuration and a plurality of nonequilibrium configurations. Portions of the resilient layer are disposed upon a plurality of points upon the facial skin. The facial skin may be stretched by attaching the nasal dilator in a nonequilibrium configuration to the facial skin by the attachment means and allowing the nasal dilator to stretch the facial skin as the resilient layer moves towards the equilibrium.
Owner:SHILON EYAL +1

Fluidic Adaptive Lens Systems with Pumping Systems

InactiveUS20090128922A1Lose weightLess bulkinessPiston pumpsMountingsEngineeringActuator
The present invention in various embodiments relates to a variety of different types of fluidic adaptive lens systems, pumping systems for implementation in such lens systems, other systems employing such lens systems, and related methods of fabrication. In at least some embodiments, the present invention relates to a lens system that includes a reservoir having at least one flexible wall, a first actuator coupled in relation to the reservoir, and a terminal at which is located at least one of an integrated fluidic lens and a port configured to be coupled to an external fluidic lens. The terminal is coupled to at least one of the reservoir and the actuator, and at least one of the actuator and a first pumping system including the actuator is capable of causing fluid to be moved at least one of from the reservoir toward the terminal, and from the terminal toward the reservoir.
Owner:RGT UNIV OF CALIFORNIA +1

Display controller, display device, display system, and method for controlling display device

A display controller is capable of changing a refresh rate, indicative of how often a screen displayed on a display device having a plurality of pixels is switched, between a low refresh rate of 40 Hz and a normal refresh rate of 60 Hz and generates (i) a dot clock (reference clock) serving as a timing signal indicative of a timing of operation in the display device, (ii) video data indicative of an image to be displayed on the screen, (iii) Hsync for defining a horizontal period of a display on the screen, and (vi) Vsync for defining a vertical period of the display on the screen, so as to supply the dot clock, the video data, Hsync, and Vsync to the display device, wherein the display controller includes a dot clock generation circuit for generating the reference clock whose frequency is constant without depending on a change of the refresh rate. This makes it possible to provide the display controller which can suppress occurrence of noise also in switching the refresh rate and which does not allow any screen derangement which is caused by the noise.
Owner:SHARP KK

Method for using the information set in the video resource

The invention discloses a video resource in the use of information collected in different ways: in the client, server and services expanded by the introduction of information-collection methods, content to achieve the expansion of video transmission, video-based applications to provide a good platform for services, including the location referred to collect information collection, parade for sets and feature set. Set referred to a more precise location of the possible new applications or new business to locate and location of the various linkages and specific targets, so as to set the target location of the various attributes of information, all kinds of attribute information to introduce more enriched video applications. The present invention introduces intra-frame, services and service mechanism, better management of the existing location set, operation set and feature set. The invention changed the existing video compression technology only attach importance to the quality and the shortcomings, and to focus on the use and control of video, the video for the future application of technology may provide a good technological platform and application reference model program.
Owner:孟智平

Unmanned testing vehicle platform for automatic driving testing site, and method

ActiveCN109187041AAchieve changeChanges to achieve conversion between different modelsVehicle testingControl systemFeedback control
The invention discloses an unmanned vehicle general platform for automatic driving testing, and a method. The unmanned vehicle general platform comprises a vehicle body shape transformation system which comprises a chassis; a telescopic device is mounted on the chassis, the telescopic device changes the size of a vehicle body through telescopic deformation, and different quick assembly simulationshells are matched to simulate different vehicle models and vehicles; a feedback control system is further mounted on the chassis; the feedback control system comprises a central control device whichis connected to a motor, a braking device and a steering device; and the central control device is further connected to a vehicle sensor measuring unit, and the motion state of a vehicle is obtained through the vehicle sensor measuring unit to decide and control various operation behaviors of the testing vehicle. One testing vehicle can simulate the various vehicles (such as cars, off-road vehicles and trucks), the perceive difficulty of the tested vehicles is increased, and the testing cost is lowered.
Owner:SHANDONG ACAD OF SCI INST OF AUTOMATION +1

Positioning apparatus

The invention relates to a positioning device for positioning an article fixed thereon. The positioning device comprises a chassis, a first turntable, a rotating plate, a linkage mechanism and a second turntable for fixing the article, wherein the first turntable is loaded on the chassis and can rotate in the direction vertical to the chassis, one end of the rotating plate is connected to the first turntable and can rotate in the direction parallel to the first turntable, the linkage mechanism is acted between the first turntable and the rotating plate and used for adjusting and fixing the rotating angle of the rotating plate, and the second turntable is arranged on the rotating plate and can rotate in the direction vertical to the rotating plate to be positioned. The positioning device not only uses the connection relation among the components and the positioning device to achieve the changing and positioning of spatial positions of the article, but also has low cost and remarkable economic effect.
Owner:HONG FU JIN PRECISION IND (SHENZHEN) CO LTD +1

Self-service shopping checkout equipment and self-service shopping checkout method

The invention relates to the field of radio-frequency identification and discloses self-service shopping checkout equipment. The self-service shopping checkout equipment comprises a server, a conveying belt, a pickup box, a radio-frequency reader erected above the conveying belt and a self-service checkout terminal, the pickup box is in butt joint with the tail end of the conveying belt, a digital lock is arranged on a door of the pickup box, at least one sensor used for detecting whether the initial end of the conveying belt is placed with goods or not is arranged under the initial end of the conveying belt, the server controls conveying and shutdown of the conveying belt, the radio-frequency reader transmits read data to the server, the server transmits data processing results to the self-service checkout terminal, the self-service checkout terminal transmits a payment request to a customer, and after the payment request is responded by the customer, the server controls to output a digital key used for unlocking the digital lock according to a signal transmitted from the self-service checkout terminal. By the self-service checkout equipment, checkout speed of a supermarket can be increased, personnel cost of the supermarket is reduced, and a convenient purchasing channel is provided for the customers.
Owner:福建爱特点信息科技有限公司

PUF circuit based on threshold deviation delay

The invention discloses a PUF (Physical Unclonable Functions) circuit based on threshold deviation delay. The PUF circuit comprises a data input module, a controller, a decision device and a PUF unit circuit, wherein external data is accessed into the input end of the data input module; the output end of the data input module is connected with the input end of the controller; the PUF unit circuit comprises an i-bit threshold deviation delay circuit; the threshold deviation delay circuit consists of two delay units; and the two delay units are respectively a first delay unit and a second delay unit. The PUF circuit has the advantages that the threshold deviation delay circuit is configured through control signals, so that a plurality of pieces of extractible process deviation exist in the PUF circuit; output signals (secret keys) of the PUF circuit can be reconstructed; and the output secret key change can be realized without replacing hardware.
Owner:NINGBO UNIV

Novel variable-diameter variable-pitch propeller

InactiveCN103010456AImprove aerodynamic performanceRealize long-span flight altitude flightPropellersVariable pitch propellerEngineering
The invention discloses a novel variable-diameter variable-pitch propeller. According to the novel variable-diameter variable-pitch propeller, a propeller cap (5) is arranged on a propeller hub (4) and provides a mounting space and a top support for a connecting rod mechanism (1), a driving mechanism (2), a sliding supporting mechanism (6) and a locking release mechanism; the driving mechanism (2) and the sliding supporting mechanism (6) are fixed on the propeller hub (4); the output of the driving mechanism (2) is connected with the connecting rod mechanism (1); a propeller blade (3) is fixed at the guide output end of the connecting rod mechanism (1) through a variable pitch mechanism (8); the bottom of the guide output end of the connecting rod mechanism (1) is connected with the sliding supporting mechanism (6); the connecting rod mechanism (1) is supported and guided through the sliding supporting mechanism (6); the driving mechanism (2) drives the connecting rod mechanism (1) to drive the propeller blade (3) to stretch out and draw back in the propeller diameter direction along with the sliding supporting mechanism (6), so that the diameter size of the whole propeller disc is changed; the connecting rod mechanism (1) is locked through the locking release mechanism (7) after the propeller blade (3) stretches out / draws back in place; and the variable pitch mechanism (8) drives the propeller blade (3) to rotate, so that variable pitch of the whole propeller is realized.
Owner:CHINA ACADEMY OF SPACE TECHNOLOGY

Method and system for testing novel contra-rotating dual-rotor motor driver

The invention discloses a system for testing a novel contra-rotating dual-rotor motor driver. The system comprises a rack mechanism part and a control part, wherein the rack mechanism part comprise a contra-rotating dual-rotor motor, a left retarding (reversing) mechanism, a right retarding (reversing) mechanism, a left universal transmission mechanism, a right universal transmission mechanism, asupporting fixing device, a test device, a working condition parameter detection sensor group, a left brake and a right brake. The invention has the beneficial effect that the system for testing a novel contra-rotating dual-rotor motor driver can be used for replacing mass inertia with rotational inertia by regulating a flywheel mechanism according to the practical situations of different vehicles, and therefore, the practical state of the dual-rotor driving system when the dual-rotor driving system is installed on a vehicle can be realized.
Owner:KUNSHAN HANHUI ELECTRONICS TECH CO LTD

Roller-lifting proportional and synchronous hydraulic control system

The invention provides a roller-lifting proportional and synchronous hydraulic control system, relating to a perforating machine. The invention solves the problem that the traditional hydraulic control system can not control the displacement conveniently. The roller-lifting proportional and synchronous hydraulic control system comprises a proportional valve, hydraulic control one-way valves, a change valve, a pressure relay, a synchronous motor and two roller-lifting hydraulic cylinders, wherein the three hydraulic control one-way valves are respectively connected with a port p, a port a and a port b of the proportional valve, and the port a of the proportional valve is connected with the pressure relay and an oil inlet of the synchronous motor through the hydraulic control one-way valves; two oil outlets of the synchronous motor are respectively connected with piston cavities of the two roller-lifting hydraulic cylinders, and piston rod cavities of the roller-lifting hydraulic cylinders are connected in parallel and then connected with the port b of the proportional valve through the hydraulic control one-way valves; and a port b of the change valve is connected with oil control ports of the hydraulic control one-way valves, an oil return port of the change valve is connected with return oil of the system, and oil drain ports of the hydraulic control one-way valves are connected with oil return pipes of the system. The roller-lifting proportional and synchronous hydraulic control system can be used for controlling the synchronous movement of a plurality of hydraulic cylinders by using one proportional valve.
Owner:TAIYUAN HEAVY IND

Method for using information sets in video resources

The invention discloses a method for using information sets in video resources. Extension of the video transmission contents is realized by introducing the information sets at the client, the server and the extension server to provide good platform for the video services based on various applications. The information sets include a position set, an operation set and a function set. Positions of new services or new application can be generated through more precise division of the position set and various positions are associated with specific objects, thus setting attribute information for various position objects. Various attribute information introduces richer video application. The invention introduces the intra-frame service and out-of-frame service mechanisms to better manage the existing position set, operation set and function set. The method changes the defect that the existing video technology only emphasizes compression and quality, puts emphasis on application and control of the videos and provides the good technical platform and application mode reference scheme for the possible video application technology in the future.
Owner:孟智平

Fulcrum-variable intelligent radial tilting pad sliding bearing device

The invention discloses a fulcrum-variable intelligent radial tilting pad sliding bearing device, which comprises a state-adjustable radial tilting pad sliding bearing, a detection circuit, a control system and an execution unit, wherein the state-adjustable radial tilting pad sliding bearing consists of fulcrum-variable radial tilting pad blocks, support units and a bearing casing; in the detection circuit, high-precision vibration sensors are mounted near the radial tilting pad sliding bearing, and the output ends of the vibration sensors are connected with a control computer; the control system comprises the control computer, a piezoelectric ceramic driving power supply, a memory alloy control unit and a switch selective circuit unit; and the execution unit consists of a support ejector head, mechanically packaged piezoelectric ceramic, cushion blocks, an alveolate packaged memory alloy and hollow screw rods. According to the device, the position of a tilting pad block back support point and radial positions of the tilting pad blocks are adjusted by the control computer, the real-time adjustment can be conducted on the working state of the radial tilting pad sliding bearing, and requirements of various working conditions are met.
Owner:XI AN JIAOTONG UNIV

Method capable of continuously adjusting color temperature and brightness of LED light

The invention relates to a method capable of continuously adjusting color temperature and brightness of a LED (light-emitting diode) light. The method comprises the steps as follows: firstly, selecting a cold white light LED and a warm white light LED; forming the selected cold white light LED into a series return circuit to connect in series with the warm white light LED; forming the selected warm white light LED into a series return circuit to connect in series with the cold white light LED; adjusting the pulse width according to a corresponding cold white light controlling circuit and a corresponding warm white light controlling circuit; providing the specific driving current for the return circuits of the cold white light LED and the warm white light LED by adjusting the pulse width; and therefore, obtaining the required color temperature and brightness. The method has a simple process and is easiness in popularization. Besides, the method can realize the continuous change of the color temperature range from 2700K to 7000K, maintain the characteristic stability of the color temperature and the light passing of the LED even if the LED lights up for a long time, and adjust the brightness change from 0 to 100%.
Owner:上海亮硕光电子科技有限公司

Sequential controllable nanometer silicon quantum dot array resistive random access memory and preparation method thereof

The invention relates to a sequential controllable nanometer silicon quantum dot array resistive random access memory and a preparation method thereof, and belongs to the technical field of non-volatile memories. The resistive random access memory comprises P and a silicon substrate material, and is characterized by also comprising a resistive silicon quantum dot multilayer film nanometer column array attached to the substrate material and an upper electrode and a lower electrode which are attached to the upper surface of the resistive silicon quantum dot multilayer film nanometer column array and the lower surface of the substrate; an insulating medium layer is arranged in the resistive multilayer film nanometer column array; and a silicon quantum dot multilayer film nanometer column is formed by at least two layers of silicon-enriched silicon nitride films which are inlaid with nanometer silicon quantum dots and have different nitrogen components or a silicon-enriched silicon oxide film sublayer which is inlaid with the nanometer silicon quantum dots and has different oxygen components. The sequential controllable nanometer silicon quantum dot array resistive random access memory can be compatible with the current micro-electronic process technology, and can show the advantage of sequential controllable nanometer silicon in resistive random access memory materials to fulfillthe aim of improving the switch ratio and stability of the resistive materials, so that nanometer silicon quantum dots are applied in silica-based nanometer memories in future.
Owner:NANJING UNIV

Computer system and touch-control pen of data processing equipment adopting handwritten operation

The invention relates to a computer system, a touch-control pen of data processing equipment adopting handwritten operation and a color adjusting method used in the computer system. The computer system comprises a touch-control pen, a signal conversion module, a signal transmission module and a host computer, wherein the touch-control pen at least comprises a color selection module and each color selection module is used for selecting one color from at least one primitive color as a selected primitive color and setting parameters of the selected primitive color; the signal conversion module is used for receiving the parameters of the selected primitive color and carrying out processing according to the parameters to obtain a color signal; the signal transmission module is used for transmitting the color signal to the host computer; and the host computer comprises a signal forwarding module which is used for receiving the color signal and forwarding the color signal to the host computer. Through the computer system, a user can optionally select a favorable color; moreover, the computer system is simple and convenient for operation.
Owner:LENOVO (BEIJING) CO LTD

Stair tread structure

InactiveUS20060196129A1Easy to useAvoid deformationTreadsFlooringCouplingElongated nose
A stair tread structure includes a tread body made up of a core layer, a plurality of lateral connecting members, a tread end member, a plurality of external connecting sheets, and an elongate nose member wherein the core layer and the tread end member are respectively made up of one or more than one board bodies of recycled wood, plywood, sawdust, and other lower quality materials that are integrally processed and firmly bonded into one piece. The core layer has a pair of lateral coupling portions symmetrically protruding at both lateral end surfaces thereon, and the lateral connecting member is provided with a coupling groove indented at one lateral end surface to correspondingly match with the coupling portions of the core layer for close engagement therewith. Therefore, via the aforementioned structure thereof, the tread body obtained thereby is efficiently manufactured in an easier and speedier manner and economically processed with the best use of recycled resources for environmental protection thereof.
Owner:LIN ALFONSO

Variable scanning region coaxial transceiving scanning laser radar

The invention relates to a variable scanning region coaxial transceiving scanning laser radar, which belongs to the field of laser management. A laser emission and signal triggering module can transmit collimated laser to an initial signal detector to generate an initial signal. A submarine-launched mirror module lifts the laser in the height direction by means of a combination of two reflectors in the vertical direction, and reflects the laser onto an MEMS scanning mirror by means of a fourth reflector. The coaxial transceiving module reflects the laser to a detected plane by means of the MEMS scanning mirror, the laser is received by means of an off-axis paraboloid reflector, and the laser is received by means of the echo signal detector after being reflected by means of a fifth reflector. The scanning laser radar realizes scanning in a certain range through the rotation of a reflecting surface in the MEMS scanning mirror, and a scanning field of view of the MEMS scanning mirror canbe enlarged through adjusting a relative angle between the fourth reflector and the MEMS scanning mirror. The variable scanning region coaxial transceivingc has the advantages of compact structure, large scanning field of view, variable scanning region and high light concentration ability, and can reduce the size of the scanning radar by means of the submarine-launched mirror module.
Owner:BEIJING INSTITUTE OF TECHNOLOGYGY

Tool attachment for a handheld machine tool

ActiveUS20140133898A1Uncomplicated and rapid and convenient for userPossible changeYielding couplingSpannersEngineeringMachine tool
In a tool attachment having an attachment housing on which a fastening interface is situated for fastening to an handheld machine tool, the fastening interface having an angular position setting unit for setting a specified angular position of the tool attachment on the handheld machine tool, and being equipped with a locking unit which, in a locked state, locks the tool attachment for operation on the handheld machine tool in the specified angular position, and, in the unlocked state, makes possible drawing the tool attachment away from the handheld machine tool, the angular position setting unit is operable in the locked state of the locking unit, to enable a change in the specified angular position.
Owner:ROBERT BOSCH GMBH

Transmission limit device for soft cable traction video camera

InactiveCN103293834ALow costEasy position controlStands/trestlesCamera body detailsEngineeringTower
A transmission limit device for a soft cable traction video camera comprises four support tower columns, pulley brackets, drivers, pulley sets, soft cables and a video camera. The four support tower columns are perpendicularly fixed on the ground to form a cuboid space for the video camera to move. One pulley bracket is fixed at the top end of each support tower column and used for fixing one pulley set. Each pulley set comprises a base, a pulley, a pulley shaft and a pulley support, wherein the pulley is arranged on the pulley shaft, two ends of the pulley shaft are fixed on two support lugs of the pulley support, and the pulley rotates around the pulley shaft, the base is provided with a frustum, a mounting shaft is arranged at the center of the frustum and provided with a threading hole, a ball is arranged between the frustum and the pulley support, and the pulley support rotates around the mounting shaft, and the two rotation directions are perpendicular to each other. The soft cables wind on the drivers and are jointly connected to the video camera through the pulley brackets and the pulley sets on the support tower columns. The drivers are fixedly connected to the bottom end of the support tower columns and connected with a computer to control winding and unwinding of the soft cables.
Owner:XIDIAN UNIV

Automatic switching method and system of dynamic festival calendar icon on basis of mobile terminal

The invention discloses an automatic switching method and system of a dynamic festival calendar icon on the basis of a mobile terminal. The method comprises the following steps: A: setting icon data corresponding to different festival calendars one by one in advance in the mobile terminal, and storing in a database; B: obtaining the current date of the mobile terminal, and judging whether the obtained current date is the festival calendar or not; C: when the current date of the mobile terminal is judged as the festival date, searching the icon data corresponding to the festival calendar from the database, and updating the icon of calendar application. According to the method, new functions are added to the mobile terminal, the method has a function of automatically switching the dynamic festival calendar icon, the dynamic change that desktop icons are configurable is realized, and convenience is brought to users.
Owner:深圳酷赛通信科技有限公司

Construction method of novel base conversion editing system and application thereof

The invention provides a construction method of a novel base conversion editing system. According to the constructed editing system, the function of a single-base gene editing system is reserved, which is characterized in that conversion from C / G to T / A of a single base at a specified site is realized, the conversion from specific sites A / T to G / C, and the conversion from the specific sites C / G toT / A and A / T to G / C can be also realized. The basic group conversion editing system comprises sgRNA, nuclease for targeted recognition of DNA sequence, cytosine deaminase, adenosine deaminase and an uracil glycosidase inhibitor. The invention also provides a product prepared by the method and related application. According to the invention, the technical limitation that only single-type base conversion can be carried out in the prior art is broken through, DNA base change in a larger range can be realized, and a base editing tool box is further enriched.
Owner:EAST CHINA NORMAL UNIVERSITY

Capacitive grounding current distributed compensation method and device for medium-voltage power supply system

The invention relates to a capacitive grounding current distributed compensation method for a medium-voltage power supply system, which belongs to the technical field of the capacitive grounding current compensation of a neutral non-grounding power supply system. In the method, capacitive grounding current distributed compensation transformers are arranged on lines, with relatively greater capacitive grounding currents, of the system in a distributed way, and only compensate the capacitive grounding currents of the corresponding lines, wherein the compensation capacity of each capacitive grounding current distributed compensation transformer is 1.1 times the capacitive grounding currents of the corresponding lines; and 40 to 60 percent of the capacitive grounding currents of the system is compensated by the capacitive grounding current distributed compensation of the whole power grid, and the other is comprehensively compensated by arc extinguishing devices of transformer substations. The capacitive grounding current distributed compensation method has the advantages that: the capacitive grounding current distributed compensation transformers are adopted, so arrangement is simple and maintenance is unnecessary; operation is simple and the capacitive grounding current is compensated in real time; and the power supply reliability of the power grid is radically improved.
Owner:JILIN PROVINCE ELECTRIC POWER RES INST OF JILIN ELECTRIC POWER CO LTD +2

Image processing apparatus, image processing method, and storage medium

An imaging apparatus includes an intermediate image generating section to generate a second structure component and a second texture component by magnifying each of a first structure component and a first texture component separated from an original image by an intermediate magnification ratio and to synthesize the second structure component and the second texture component to generate an intermediately magnified image, and a final image generating section to generate a finally magnified image by synthesizing a finally magnified structure component generated by magnifying a third structure component separated from the intermediately magnified image by a final magnification ratio, and a finally magnified texture component generated by magnifying the first texture component by the final magnification ratio.
Owner:CASIO COMPUTER CO LTD

Driving assistant device and driving assistant method

InactiveCN110070736AReduced total cost to societyLow total social costArrangements for variable traffic instructionsTime informationInformation processing
The invention belongs to the technical field of intelligent driving, and discloses a driving assistant device and a driving assistant method. The device comprises a conventional information processingmodule (M1), an instant message acquisition module (M2), an event information processing module (M3) and an information projection unit (1); the conventional information processing module (M1) is suitable for presetting conventional display information and updating time, and projecting the conventional display information on a road through the information projection unit (1) when the updating time is satisfied; the instant message acquisition module (M2) is suitable for collecting real-time traffic information; and the event information processing module (M3) is suitable for performing priority comprehensive ordering for the conventional display information and the real-time traffic information, projecting the information with high priority on the road through the information projection unit (1), and adding the information with high priority to the previously projected conventional display information or substituting the previously projected conventional display information. With thedevice and the method provided by the invention, social total cost of the driving assistant device can be reduced, driving assistant information utilization rate is improved, and driving safety and driving efficiency are improved.
Owner:HASCO VISION TECHNOLOGY CO LTD

Optical waveguide structure capable of regulating and controlling boundary state of topological photonic crystal

The invention provides an optical waveguide structure capable of regulating and controlling the boundary state of a topological photonic crystal. The optical waveguide structure comprises an upper metal plate, a lower metal plate, a waveguide, a background material and a shell, wherein the upper metal plate and the lower metal plate are arranged in the shell, the waveguide is arranged between theupper metal plate and the lower metal plate, the waveguide is composed of a part A and a part B, the part A is formed by arranging unit cells with moderate topological properties, the part B is formedby arranging unit cells with non-moderate topological properties, each unit cell is formed by arranging six cylindrical dielectric cylinders with the radius of 0.12a, the cross section of each unit cell is in a regular hexagon shape, the distance radius from the center of each unit cell to the corresponding cylindrical dielectric cylinder in the unit cell is R, the distance between the centers ofevery two adjacent unit cells is a lattice constant a, the unit cells with the moderate topological property meet a / R=3.36, and the unit cells with the non-moderate topological property meet a / R=2.8.The problems that a traditional waveguide photon is weak in locality and low in transmission efficiency, and the frequency cannot be regulated and controlled are solved.
Owner:JIANGSU UNIV

Application of novel base conversion editing system on gene therapy

The invention innovatively provides an application of a novel base conversion editing system on gene therapy for the first time; according to the system, the function of a single-base gene editing system is reserved, which is characterized in that conversion from C / G to T / A of a single base at a specified site is realized, conversion from A / T to G / C is realized, and the conversion from C / G to T / Aand from A / T to G / C can be also realized. The basic group conversion editing system comprises sgRNA, nuclease, cytosine deaminase, adenosine deaminase and uracil glycosidase inhibitors, and the nuclease, the cytosine deaminase, the adenosine deaminase and the uracil glycosidase inhibitors can target and recognize DNA sequences. The invention further provides a pharmaceutical composition containingthe base conversion editing system and the application of the pharmaceutical composition in gene editing, gene therapy, drug screening and model animal construction.
Owner:EAST CHINA NORMAL UNIV
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