Antioxidizing composition for scavenging free radicals, pharmaceutical composition comprising the same, and process for preparing the same

A composition and compound technology, which can be used in drug combinations, compositions for inhibiting chemical changes, and medical preparations containing active ingredients, etc., can solve problems such as low bioavailability of drugs and inability to enter lymph

Inactive Publication Date: 2000-12-06
刈田毅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0027] In Kampo medicine, it is known that such antioxidant substances play an important role in the mechanism of action. However, they are also water-soluble drugs, and there are still problems in entering the lymph because they are taken orally.
[0028] When the above-mentioned antioxidant enzymes and antioxidant substances are taken orally, during the absorption process of the drug, these enzymes will be decomposed by the metabolism of the digestive tract and liver, so the bioavailability of the drug is not high
In addition, even if the drug is not taken orally, although it can enter the blood, it basically cannot enter the lymph.

Method used

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  • Antioxidizing composition for scavenging free radicals, pharmaceutical composition comprising the same, and process for preparing the same
  • Antioxidizing composition for scavenging free radicals, pharmaceutical composition comprising the same, and process for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0108] (1) Production of Antioxidant Composition-1

[0109] The main ingredient of the antioxidant composition-1 of the present invention was mixed according to the types and quantities of the essential oil components shown in Table 2. The spices used are purchased from Ogawa Fragrance Company.

[0110] Table 2 Preparation of Antioxidant Composition-1

[0111] Type Quantity (mg)

[0112] Menthol 19.8

[0113] Limonene 3.2

[0114] Citral 1.6

[0115] Eucalyptus oil 5.6

[0116] Thyme oil 1.6

[0117] Lemon oil 1.6

[0118] Total 33.4

[0119] (2) Production of pharmaceutical composition containing antioxidant composition-1

[0120] The antioxidant composition prepared in (1) was mixed with the following bases in the amounts shown in Table 3 to prepare a pharmaceutical composition containing antioxidant composition-1.

[0121] Table 3 The pharmaceutical composition containing antioxidant composition-1

[0122] S...

Embodiment 2

[0135] (1) Production of Antioxidant Composition-2

[0136] The main ingredient of the antioxidant composition-2 of the present invention was mixed according to the types and quantities of the essential oil components shown in Table 4. The spices used are purchased from Ogawa Fragrance Company.

[0137] Table 4 Preparation of Antioxidant Composition-2

[0138] Type Proportion (%) Quantity (mg)

[0139] Eucalyptus oil 40 0.44

[0140] Citrus essential oil 30 0.33

[0141] Lamiaceae essential oil 25 0.275

[0142] Thyme Oil 5 0.55

[0143] Total 100 1.1

[0144] (2) Manufacture of pharmaceutical composition containing antioxidant composition

[0145] The antioxidant composition-2 prepared in (1) was mixed with the following bases in the amounts shown in Table 5 to prepare a pharmaceutical composition.

[0146] Table 5 The pharmaceutical composition containing antioxidant composition-2

[0147] Substrate Quantity (mg)

[0148]Main agent 1.1

[0149] Pol...

example 3

[0159] (Example 3) to the test result of FIV natural infection cat

[0160] (1) Test animals

[0161] As animal experimental models of AIDS, feline immunodeficiency virus (FIV)-infected cats (n=1) with AIDS symptoms and FIV-infected cats without AIDS symptoms (n=2) were used.

[0162] (2) Administration method

[0163] The transdermal absorbent in the example (2) is fixed on the inside of the cat's collar with a double-sided tape, and the collar is wrapped around the cat's neck so that the transdermal absorbent is in close contact with the skin. The preparation is changed every 3 days.

[0164] (3) Administration schedule

[0165] According to the method described in (2), the above-mentioned percutaneous absorption agent was fixed on the collar, administered for 4 weeks, and then stopped for 2 weeks. Then, the placebo was administered in the same manner as the above-mentioned percutaneous absorption agent for 4 weeks. Thereafter, the above-mentioned percutaneous absorptio...

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Abstract

An anti-oxidizing composition for scavenging free radicals, comprising at least one essential oil component containing a number of fat-soluble, low-molecular-weight compounds, a pharmaceutical composition comprising the above composition, and a process for preparing the same are described. Percutaneous absorption of the pharmaceutical composition is effective in treating immune diseases, particularly AIDS.

Description

technical field [0001] The present invention relates to an antioxidant composition for the purpose of removing free radicals generated in the body, a pharmaceutical composition containing the same, and a production method thereof. Background technique [0002] Active oxygen and free radicals that cause various problems in the human body are produced during the invasion of bacteria into the human body, in the chitin-chitosan oxidase system, in the arachidonic acid cascade generated in the system and during the saccharification process. The so-called active oxygen is O 2 - (hyperhydroxyl radical) and 1 o 2 (singlet oxygen) and OH (hydroxyl radical) in general. ·O 2 - is triplet oxygen in the ground state ( 3 o 2 ) formed by receiving an electron. In addition, the two unpaired electrons of the oxygen molecule lose their pairing, and then enter the π orbital of one of the oxygen atoms, and the oxygen formed after the other orbital becomes an empty orbital is called sin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/70A61K36/00A61K36/532A61K36/534A61K36/535A61K36/537A61K36/61A61K36/752A61K36/8962A61K47/06A61P31/18A61P37/04A61P39/06C07C259/06C09K15/34
CPCA61K36/534A61K36/535A61K36/537C09K15/34A61K9/70A61K36/61A61K47/06C07C259/06A61K36/8962A61K36/532A61K9/0014A61K36/752A61P17/00A61P31/18A61P37/04A61P39/06A61K2300/00
Inventor 刈田毅
Owner 刈田毅
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