Use of aromatase inhibitor in treatment of uropoiesis disease and method for studying uropoiesis disease

Abstract

The invention relates to the use of an aromatase inhibitor for the manufacture of a pharmaceutical composition to be used in the treatment of 1) detrusor urethral sphincter dyssynergia in men, wherein said detrusor urethral sphincter dyssynergia is urethral dysfunction which is due to decreased androgen to estrogen ratio in the patient, or 2) decreased androgen to estrogen ratio in men. In addition, the invention also relates to a method for the in vivo investigation of the influence of a certain condition on the urinary function of male individuals using an animal model of male rodents wherein said rodents have been subjected to said condition, anesthetized, provided with a pressure transducer connected to an infusion cannula inserted in the bladder, a flow probe inserted in the distal urethra and connected to a flow meter, infused with a solution into the bladder to induce micturition, and wherein the bladder pressure and urinary flow are registered as function of time. According to the invention, electrode attached to muscles of the lower urinary tract is provided, and that the electrical activity of said muscles are registered simultaneously with the registering of the bladder pressure and the urinary flow.

Description

[0001] The present invention relates to the use of aromatase inhibitors in the treatment of male detrusor urethral sphincter dyssynergia (DUSD). It also relates to a method for studying in vivo the effects of certain conditions on male urinary function using a male rodent model. Background technique [0002] Published documents and other materials used herein to illustrate the background of the invention, particularly the Examples which provide further pertinent experimental details, are incorporated by reference. [0003] DUSD and its usual treatments [0004] The normal urinary process involves maintaining relaxation of the periurethral smooth and striated muscles during detrusor contraction. Figure 2 shows the anatomy of the human and rat lower urinary tract (a and b). In this figure, D indicates detrusor muscle, U indicates urethra, RB is striated sphincter (urethral striated sphincter), PR is prostate, VPR is ventral prostate, LPR is lateral prostate, S is seminal vesic...

AI Technical Summary

Problems solved by technology

Although higher than physiological blood levels of estrogen are required to promote growth of the perurethral prostate in adult animals, their presence suggests that a reduced ratio of estrogen or androgen to estrogen may be associated with normal and excessive growth of the human prostate and detrusor urethra. development of sphincter dyssynergia

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