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Pharmaceutical composition containing gen-seng total saponin and astragalus root total saponin, its preparing process and application

A technology of total astragalus saponins and total ginseng saponins is applied in the directions of drug combinations, medical preparations containing active ingredients, drug delivery, etc., and can solve the problem of not finding traditional Chinese medicine injection preparations and the like.

Inactive Publication Date: 2006-12-20
张平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Checking the patent literature, no Chinese medicine injection preparations prepared from ginseng and astragalus were found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Effects on myocardial injury in mice with viral myocarditis

[0030] Experimental animals: 4-week-old male purebred BALB / c mice. (The model of Qi deficiency was created by the Chinese Medicine Pharmacology Teaching and Research Office of Shenyang Pharmaceutical University according to the literature)

[0031] Experimental Virus: Coxsackie B 3 Cardiotropic virus strain (CVB3m) virus stock solution titer, 50% tissue infection rate (TCID) was 10-6.

[0032] Experimental drug: each group of preparations of the present invention (provided by the laboratory of Guangdong Tianzhijiao Drug Development Co., Ltd.)

[0033] Commercially available astragalus injection (purchased by Beijing Baitasi Pharmaceutical Wholesale Company, produced by Chia Tai Qingchunbao Pharmaceutical Co., Ltd.)

[0034] normal saline

[0035] Experimental method: Qi-deficiency mice were randomly divided into 5 groups. Model group (infection plus normal saline), 15 animals; the water injection group o...

Embodiment 2

[0040] Protective effect on myocardial ischemia in dogs with qi deficiency

[0041] Experimental animal: Beagle dog, weighing 7.5-10kg. (The model of Qi deficiency was created by the Chinese Medicine Pharmacology Teaching and Research Office of Shenyang Pharmaceutical University according to the literature)

[0042] Experimental drug: each group of preparations of the present invention (provided by the laboratory of Guangdong Tianzhijiao Drug Development Co., Ltd.)

[0043] Astragalus Saponin Injection (provided by Shanxi Academy of Traditional Chinese Medicine)

[0044] normal saline

[0045] Experimental method: The experimental dogs were taken and divided into a normal saline group, an astragalus saponin injection group, a water injection group of the present invention, an infusion group of the present invention, and a powder injection group of the present invention. The dose was 4.0 mg effective site / kg each time, and the normal saline group was given an equal volume, o...

Embodiment 3

[0049] Protective effect on acute cerebral ischemia in rats with qi deficiency

[0050] Experimental animals: SD rats, body weight (350±47), male and female.

[0051] Experimental drug: each group of preparations of the present invention (prepared from the effective parts of saponins, provided by the laboratory of Guangdong Tianzhijiao Drug Development Co., Ltd.)

[0052] Astragalus Saponin Injection (provided by Shanxi Academy of Traditional Chinese Medicine)

[0053] normal saline

[0054] Experimental method: The rats were divided into a normal saline group, an astragalus saponin injection group, a water injection group of the present invention, an infusion group of the present invention, and a powder injection group of the present invention. Each dose of 4.0 mg effective site / kg, the normal saline group was given an equal volume, and the experiment was started 2 hours after administration.

[0055] Acute incomplete cerebral ischemia model: Rats were anesthetized with so...

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PUM

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Abstract

The invention discloses a pharmaceutical composition containing gen-seng total saponin and astragalus root total saponin, its preparing process and application, wherein the composition comprises the significant part of ginsenoside and astragalus root saponins extracted from traditional Chinese medicinal gen-seng and astragalus root, as well as medicinal adjuvant. The obtained injection can be used for treating cardiovascular and cerebrovascular diseases. Pharmacological experiment has shown that the pharmaceutical composition preparation provided by the invention has better pharmaceutical actions for treating energy deficiency type cerebrovascular diseases.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a pharmaceutical composition containing total ginseng saponins and total astragalus saponins and preparation and application thereof. Background technique [0002] In traditional Chinese medicine prescriptions, the compatibility of drugs with similar performance and efficacy can enhance the curative effect. [0003] The determination of traditional Chinese medicine compound prescription is to determine the treatment method on the basis of analyzing the pathogenesis, and to form a prescription that meets the needs of the disease under the guidance of the treatment method. Treatment is based on the selection of appropriate drugs and appropriate doses of drugs. Under the guidance of traditional Chinese medicine theory, the combination is formed. Treatment is the theoretical basis of prescriptions, and prescriptions are the concrete embodimen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/08A61K9/14A61P9/00
Inventor 张平
Owner 张平