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Medical composition
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A composition and coating technology, applied in the direction of drug combination, drug delivery, non-active ingredients of polymer compounds, etc., can solve problems affecting patient compliance and poor palatability
Inactive Publication Date: 2007-01-31
GLAXO GRP LTD
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Abstract
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Problems solved by technology
[0011] Although the lipid coating masks to some extent the bitter taste of cefuroxime axetil when administered orally, the bitter taste of cefuroxime axetil is so strong that these suspensions and compositions still have a bitter taste, and when administered to children There are obvious problems
Additionally, the suspensions may have a "gritty" feel in the mouth, making them less palatable than other antibiotic suspensions
These factors may affect patient compliance because, especially in young children, unpalatable antibiotics tend to be discontinued once the patient improves, rather than continuing the course until the scheduled period
Method used
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the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Abstract
A composition comprising cefuroxime axetil in particulate form, the particles being coated with integral coatings of a lipid or mixture of lipids which are insoluble in water in which the composition further comprises a sweetener system and a texture modifier which serves to mask the bitter taste of cefuroxime axetil upon oral administration is disclosed.
Description
technical field [0001] The present invention relates to compositions, in particular to pharmaceutical compositions containing 1-acetoxyethyl ester of cefuroxime, whose approved name is cefuroxime axetil. Background technique [0002] Cefuroxime as disclosed in British Patent Specification 1453049 is a valuable broad-spectrum antibiotic characterized by high activity against a wide range of Gram-positive and Gram-negative Enhanced by the very high stability of β-lactamases produced by a wide range of Gram-negative microorganisms. Cefuroxime and its salts are primarily used as injectable antibiotics because of their poor absorption from the gastrointestinal tract. [0003] Esterification of the carboxyl group of cefuroxime to 1-acetoxyethyl ester to give cefuroxime axetil improves the efficiency of oral administration as disclosed in British Patent Specification 1571683. The presence of the 1-acetoxyethyl ester group results in substantial absorption of the compound from the...
Claims
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Application Information
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