Method for preparing target magnetic nano drug for treating leucosis

A magnetic nanometer and magnetic nanoparticle technology is applied in the field of biochemical medicine to achieve the effects of reducing systemic toxicity, low development cost and increasing drug concentration

Inactive Publication Date: 2007-03-07
SOUTHEAST UNIV
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  • Abstract
  • Description
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Problems solved by technology

Since the preparation of monodisperse magnetic nano-drug carriers has always been a technical bottleneck, there have been no reports of using magnetic nanoparticles as drug carriers to directly act on target cells.

Method used

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Embodiment Construction

[0014] The targeted magnetic nano-medicine for treating leukemia and the preparation method of the present invention use surface-functionalized monodisperse magnetic nanoparticles Ni, or Fe 2 o 3 , or Fe 3 o 4 It is a carrier, and the surface of the carrier is loaded with doxorubicin, or daunorubicin, or other drugs for treating leukemia; wherein the monodisperse magnetic nanoparticles and doxorubicin, or daunorubicin, or other drugs for treating leukemia The weight ratio of drugs is 1:2-1:5. The other drugs for treating leukemia are antibiotics (such as epirubicin, pingyangmycin), and Chinese herbal medicines (such as taxol (paclitaxel)).

[0015] (1) Monodisperse surface functionalized Ni, or Fe 2 o 3 , or Fe 3 o 4 Preparation of nanoparticles:

[0016] Monodisperse Ni, or Fe was prepared by electrodeposition under electrochemical oxidation conditions 2 o 3 , or Fe 3 o 4 of nanoparticles. The electrolysis process is carried out in TBA-Br-2 propanol solution, whe...

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Abstract

The present invention relates to a preparation method of magnetic nano medicine for curing leukemia. Said preparation method uses surface-functional monodisperse magnetic nano particle Ni or Fe2O3 or Fe3O4 as carrier, on the surface of carrier the doxorubicin or daunorubicin or other medicine for curing leukemia can be loaded. Under the condition of externally-applied magnetic field it can be used for making auxiliary therapy, and can greatly raise medicine concentration in leukemia cell interior of tumor zone, and can reduce the hazard due to medicine resistance of cell to obtain the action of controlling and effectively killing cancer cell.

Description

[0001] The invention relates to the technical field of biochemical medicine, in particular to a preparation method of targeted magnetic nano-medicine for treating leukemia. Background technique [0002] Malignant tumors are one of the leading causes of death in the world today. Although chemotherapy has been developed and perfected for more than half a century and has become one of the main means of comprehensive treatment of malignant tumors, anticancer drugs kill normal tissue cells as well as tumor cells, so they are often used in clinical applications. Cause serious toxic and side effects. Therefore, it has become a hot research topic for medical workers to seek a treatment approach and method that can protect normal tissues and organs and have the greatest possibility of killing tumor cells. [0003] Leukemia is a malignant disease of the hematopoietic system. During the development process, hematopoietic cells with impaired differentiation and maturation proliferate abn...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K9/14A61K47/02A61P35/00
Inventor 王雪梅张仁云吕刚吴春惠李景源高峰程坚陈宝安付德刚李小毛关之群
Owner SOUTHEAST UNIV
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