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Botanical originated nim oil contraception formulation

A neem oil, plant-derived technology, applied in plant raw materials, plant/algae/fungus/moss components, drug combinations, etc., can solve the problems of environmental and other biological toxic side effects, cost, non-persistence, etc.

Inactive Publication Date: 2007-05-23
殷中琼
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing rodenticides in our country mainly increase the mortality rate of rats, but none of them have persistent effect, and the longest period of low density after rodent control is only about one year, after which the rat density gradually increases and returns to the original level, and Traditional rodenticides also have disadvantages such as toxic side effects and high cost to the environment and other organisms

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1: 30% Neem Oil Vegetable Contraceptive Microcapsules

[0045] In the reactor, add 30g of neem oil or different solvent extracts of neem oil into 25g of 10% gelatin aqueous solution, add 6g of sucrose ester emulsion at the same time, stir, heat to 42-45°C, then add 25g of 10% arabic acid Glue solution, adjust the pH value to 4.5-5.5, stir, cool to below 10°C, then adjust the pH to 8-9 with 20% NaOH, stir for 15 minutes, and finally add 4g of diisopropyl phosphate and 10g of 30% formaldehyde solution, Stir at this temperature for 1h. Stand still, discard the supernatant, wash the microspheres with water until nearly neutral, and dry them for later use.

Embodiment 2

[0046] Example 2: 50% Neem Oil Vegetable Contraceptive Microcapsules

[0047] In the reactor, add 50g of neem oil or different solvent extracts of neem oil into 20g of 10% gelatin aqueous solution, add 4g of sucrose ester emulsion at the same time, stir, heat to 42-45°C, then add 20g of 10% arabic Glue solution, adjust the pH value to 4.5-5.5, stir, cool to below 10°C, then adjust the pH to 8-9 with 20% NaOH, stir for 15 minutes, and finally add 5g of 30% formaldehyde solution and 1g of diisopropyl phosphate, Stir at this temperature for 1 h. Stand still, discard the supernatant, wash the microspheres with water until nearly neutral, and dry them for later use.

Embodiment 3

[0048] Example 3: 70% Neem Oil Vegetable Contraceptive Microcapsules

[0049] In the reactor, add 70g of neem oil or different solvent extracts of neem oil into 13g of 10% gelatin aqueous solution, add 1g of sucrose ester emulsion at the same time, stir, heat to 42-45°C, then add 13g of 10% arabic acid Glue solution, adjust the pH value to 4.5-5.5, stir, cool to below 10°C, then adjust the pH to 8-9 with 20% NaOH, stir for 15 minutes, and finally add 2g of 30% formaldehyde solution and 1g of diisopropyl phosphate, Stir at this temperature for 1 h. Stand still, discard the supernatant, wash the microspheres with water until nearly neutral, and dry them for later use.

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PUM

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Abstract

The invention provides a highly effective, low toxicity nim contraceptive which can be in the dosage forms of microcapsule and granule, the contraceptive is prepared from nim oil or the extracts of different solvents of nim oil as the contraception composition, and a finite proportion of various flavorings, which has strong contraceptive actions to mice.

Description

technical field [0001] The invention relates to a new natural medicine product, which is suitable for controlling rodent damage from an ecological point of view, and is a plant source neem oil contraceptive preparation with good contraceptive effect. Background technique [0002] Neem oil (Neem oil) is the extract of neem (Azadirachta indica A. Juss) seeds. As an anti-fertility substance, neem oil is almost blank in domestic research. Numerous studies have confirmed that neem oil has great anti-fertility effects. However, the research on the dosage form of neem oil is mainly based on emulsifiable concentrate at present, and it is not even made into a preparation at all, and it is used directly, which has caused defects such as not being able to adapt to the diversification of its application and affecting the palatability of animals due to the peculiar smell of the medicine. In addition, traditional contraceptive dosage forms can no longer meet the needs of modernization, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/58A61P15/16A61K131/00A61K9/48
Inventor 吴成奎殷中琼
Owner 殷中琼
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