Wet wipes having skin health benefits

A technology for wet wipes and skin barriers, which is applied in the field of oil-in-water emulsion composition solutions, and can solve problems such as incomplete optimization

Inactive Publication Date: 2002-05-08
KIMBERLY-CLARK WORLDWIDE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The current balance of physical properties has not been fully optimized, such as softness, elasticity, strength, integrity and resilience

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Lipid-rich wet wipe formulation that strengthens the skin barrier against skin irritation, namely trypsin from the fecal enzyme

[0070] Using EpiDerm TM Skin model (Epi-200, Mattek Corporation, Ashland, MA) to determine the ability of lipid-rich wet wipe formulations to enhance skin barrier function against penetration by trypsin (skin irritant, fecal enzymes), and the response to prevent interleukin-1 alpha (IL-1 alpha), a measure of inflammation.

[0071] deal with

[0072] Formulations 1 and 2 formulations enhanced EpiDerm TM The barrier function of the skin of the skin model to trypsin, meanwhile, the results of IL-1α assay after 6 hours showed a reduction of the pro-inflammatory response compared with the trypsin control.

Embodiment 2

[0074] Transepidermal Water Loss (TEWL) Measurements Show Lipid-Enriched Wet Wipe Formulation Promotes Barrier Function Restoration

[0075]

[0076]

[0077] As measured by TEWL, formulations 5 and 6 were able to restore the skin barrier function compared to the untreated site. In addition, the formulation of formula 6 restored the barrier function significantly better than that of formula 5. Formulation 5 contains liposome NSLE, a product of the company Sederma (Le Perrag-en-Yvelines, France), which is a recommended product and has been marketed as a skin protection product.

Embodiment 3

[0079] Conductometric measurements showed that the lipid-enriched wet wipe formulation enhanced skin moisturization.

[0080] Baseline 1 hour 2 hours 4 hours 6 hours

[0081] 1 hour 2 hours 4 hours

[0082] 1, 2 and 4 hours after application of the formulation, the formulation of Formulation 6 significantly enhanced the moisturization of the skin compared to the untreated site. The formulation of Formulation 5 failed to enhance skin moisturization at any time tested. Formulation 5 contains liposome NSLE, a product of Sederma (Le Perrag-en-Yvelines, France), which is a recommended product and has been marketed as a product for protecting the skin barrier function.

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PUM

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Abstract

A skin health enhancing soft wet wipe or wipe-type product, such as a baby wipe, an adult wipe, hand wipe, a face wipe, a cosmetic wipe, a household wipe, an industrial wipe, a personal cleansing wipe, cotton balls, cotton tipped swabs, and the like, can be made by combining the wipe or wipe-type product with an oil-in-water emulsion composition comprising a natural fat or oil, sterol or sterol derivative, humectant, emulsifying surfactant, and water.

Description

field of invention [0001] This invention describes wet wipes and wipe-type products. More specifically, the present invention describes wet wipes and wipe-type products that can be used for a variety of purposes, including cleansing, make-up removal, and hygiene, which contain oil-in-water that cleans the surface of the skin and are beneficial for promoting skin health Emulsion composition solution. Background of the invention [0002] The stratum corneum, the outermost layer of the skin, regulates skin moisture levels and acts as a barrier against chemicals and other irritants from the surrounding environment. The complex arrangement of lipids in the space between stratum corneum cells allows for normal barrier function. The multilayer structure of cholesterol, ceramides and fatty acids, along with certain other minor lipids, forms the main barrier for the penetration of hydrophilic substances into or through the skin. The relationship between barrier function and skin h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M35/00A61KA61K8/00A61K8/02A61K8/30A61K8/31A61K8/34A61K8/36A61K8/37A61K8/92A61K8/96A61K8/97A61Q1/02A61Q1/14A61Q17/00A61Q19/00
CPCA61Q19/00A61K8/0208A61K8/062A61K8/63A61K8/92
Inventor D·G·克尔兹斯克B·A·兰格D·R·奥茨B·M·内尔森
Owner KIMBERLY-CLARK WORLDWIDE INC
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