Wet wipes having skin health benefits
A technology for wet wipes and skin barriers, which is applied in the field of oil-in-water emulsion composition solutions, and can solve problems such as incomplete optimization
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Embodiment 1
[0069] Lipid-rich wet wipe formulation that strengthens the skin barrier against skin irritation, namely trypsin from the fecal enzyme
[0070] Using EpiDerm TM Skin model (Epi-200, Mattek Corporation, Ashland, MA) to determine the ability of lipid-rich wet wipe formulations to enhance skin barrier function against penetration by trypsin (skin irritant, fecal enzymes), and the response to prevent interleukin-1 alpha (IL-1 alpha), a measure of inflammation.
[0071] deal with
[0072] Formulations 1 and 2 formulations enhanced EpiDerm TM The barrier function of the skin of the skin model to trypsin, meanwhile, the results of IL-1α assay after 6 hours showed a reduction of the pro-inflammatory response compared with the trypsin control.
Embodiment 2
[0074] Transepidermal Water Loss (TEWL) Measurements Show Lipid-Enriched Wet Wipe Formulation Promotes Barrier Function Restoration
[0075]
[0076]
[0077] As measured by TEWL, formulations 5 and 6 were able to restore the skin barrier function compared to the untreated site. In addition, the formulation of formula 6 restored the barrier function significantly better than that of formula 5. Formulation 5 contains liposome NSLE, a product of the company Sederma (Le Perrag-en-Yvelines, France), which is a recommended product and has been marketed as a skin protection product.
Embodiment 3
[0079] Conductometric measurements showed that the lipid-enriched wet wipe formulation enhanced skin moisturization.
[0080] Baseline 1 hour 2 hours 4 hours 6 hours
[0081] 1 hour 2 hours 4 hours
[0082] 1, 2 and 4 hours after application of the formulation, the formulation of Formulation 6 significantly enhanced the moisturization of the skin compared to the untreated site. The formulation of Formulation 5 failed to enhance skin moisturization at any time tested. Formulation 5 contains liposome NSLE, a product of Sederma (Le Perrag-en-Yvelines, France), which is a recommended product and has been marketed as a product for protecting the skin barrier function.
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