Process for preparing broad spectrum anti-virus medicine and its use

Abstract

The broad spectrum anti-virus medicine is a composition of general organic phenolic acid and / or general organic phenolic salt and its glucoside extracted from chickweed and other stellaria plant through two extraction processes. It may be used to inhibit several viruses of RNA and DNA. It may be used in preparing medicine for inhibiting HIV, hepatitis virus, flu virus, parainfluenza virus, adenovirus and other viruses. It has no toxicity. It may be used in preparing at least ten kinds of medicine.

Description

1. Technical field: [0001] The invention relates to a preparation method and application of an antiviral drug, in particular to a preparation method and application of a broad-spectrum antiviral traditional Chinese medicine. 2. Background technology: [0002] At home and abroad, there is still a lack of truly effective drugs in the treatment of many viral diseases, especially the infection or mixed infection caused by a variety of viruses or variable viruses. Difficult problem. [0003] Diseases caused by some viruses are almost fatal, such as HIV, Ebola virus, rabies virus, etc.; Viral myocarditis and the like can cause people to lose their labor force or even be disabled for life, especially some viruses are one of the important causes of cancer, so the diseases caused by viruses are very harmful. Therefore, the whole world is now urgently looking for a broad-spectrum antiviral drug that can simultaneously have a strong inhibitory effect on RNA and DNA viruses in vivo, a...

AI Technical Summary

Problems solved by technology

[0017] 1. The median time for symptom relief after clinical use of the drug is about 6 days, and the control group is 7 days, which can shorten the course of the disease by about 1.2. Although this is already a great achievement, the patient still needs to endure nearly 6 days of pain after taking the drug. pain to heal

[0018] 2. Influenza virus neuraminidase inhibitors can only inhibit influenza A and B viruses, but for other viruses that can cause respiratory infections such as influenza virus C, parainfluenza virus, respiratory syncytial virus and adenoviruses belonging to the DNA class, etc. , Rhinovirus, Ecovirus, Coxsackievirus, etc. can also cause respiratory infections

Whether these viruses are intentionally inhibited has not been reported, so the scope of its treatment can not really solve the virus influenza, there are relatively large limitations

[0019] 3. There is no report on whether it has a therapeutic effect on headaches during the onset of influenza

[0020] 4. Influenza virus neuraminidase inhibitors still have certain adverse reactions. For example, Zanamivir has flu-like symptoms, diarrhea, dizziness, nausea and vomiting, etc., and some patients have tracheospasm, especially in animal experiments with placental transfer. , so it is not sure whether it is safe during pregnancy, especially Zanamivir should not be taken in the first trimester of pregnancy, but must be prescribed by a doctor

[0021] 5. Zanamivir etc. are not suitable for children under 12 years old

[0022] 6. The oral bioavailability of Zanamivir is only 2%, so it cannot be administered orally

[0023] 7. The market price of a retail package of Zanamivir is 200 Hong Kong dollars (25 US dollars), and the market price of Oseltamivir is 250 Hong Kong dollars (30 US dollars). The price is relatively high, and it is difficult for low- and middle-income patients in China and developing countries to afford it.

However, because HIV is not only a variable virus like influenza virus, but also a variety of viruses: HIV will mutate even if there is no external factor stimulation, so far at least a dozen kinds of HIV have been found in the world. Also found at least 8 kinds, this is not what the existing nucleic acid drugs can solve

In addition, the side effects of nucleic acid drugs are relatively large, their use is limited, their price is relatively expensive, and they need to be used for a long time, and ordinary people still cannot afford them. no way"

[0028] In short, in the current domestic and foreign pharmaceutical markets, among all the drugs used to treat viral diseases, there are only some drugs that are highly specific and effective against a small number of viruses. or expensive etc.

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