Extracting process for decoction of poria, Bighead Atractylodes, cinnamom and Lirorice and its medicinal use

An extraction process, the technology of Linggui surgery, applied in the field of medicine

Inactive Publication Date: 2002-11-06
SHENYANG PHARMA UNIVERSITY
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, so far, most of the studies on the compound Linggui Zhugan Decoction are its addition and subtraction and clinical application, while there are few reports on the extraction process and pharmacodynamics. Fu Yanling, Zhang Weijian, etc. Part of the work has been done [Fu Yanling et al., Journal of Beijing University of Traditional Chinese Medicine 1990, 13(4), 47-49]

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  • Extracting process for decoction of poria, Bighead Atractylodes, cinnamom and Lirorice and its medicinal use

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Experimental program
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Embodiment

[0011] 1. Select the anti-arrhythmia experiment (against chloroform-induced ventricular fibrillation in mice) to conduct a preliminary screening of 11 extraction methods, select 5 of them, and choose anti-myocardial ischemia experiment (anti-isoproterenol-induced rat myocardial Ischemia) re-screened the selected 5 methods to determine the best extraction solvent, the results are shown in Figure 1.

[0012] 2. Extraction process optimization: choose L 9 (3) 4 Orthogonal tables were used to improve the standard of the three active ingredients in the formula and the yield of the extract, and the factors affecting the extraction efficiency, such as the amount of extraction solvent, the number of extractions, and the extraction time, were investigated, and the optimal process was determined.

[0013] 3. The pharmacodynamic results of anti-myocardial ischemia show that Linggui Zhugan Decoction can significantly prolong the survival time of mice under normal pressure and hypoxia con...

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Abstract

The present invention provides an extracting process of poria, cinnamom, largehead atractylodes and licorice decoction and the process is optimized through orthogonal design. In the recipe, the ratioof poria, cinnamom, largehead atractylodes and licorice is 12 to 9 to 9 to 6, and the medicine materials are solvent extracted. The selected solvent includes water and ethyl alcohol solution in different concentration and the extraction process may be either one including first water extraction and ethyl alcohol precipitation or one including first ethyl alcohol extraction and water precipitation. The present invention may be used in preparing medicine for treating myocardial ischemia and arrhythmia.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to an extraction process of Linggui Zhugan Decoction and its medical application. Background technique: [0002] In "Synopsis of the Golden Chamber", Zhang Zhongjing first extracted the name of the disease "phlegm retention", and created Linggui Zhugan Decoction, which treats the drink from the spleen. "Article 67: "If typhoid fever is vomited, the heart will be full, the breath will rush to the chest, the head will be dizzy, and the pulse will be tense. Sweating will move the menstruation. As a shaker, Fuling Guizhi Baizhu Gancao Decoction Of". "Golden Chamber·Treatment of Phlegm Retention, Cough and Pulse Syndrome" says: "Linggui Zhugan Decoction is the main treatment for phlegm retention under the heart, fullness of the chest and hypochondrium, and dizziness." It is also said that "the husband is short of breath and has a slight drink, which should be removed from the urine s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P9/06A61P9/10
Inventor 毕开顺宋宗华
Owner SHENYANG PHARMA UNIVERSITY
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