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Device and method for detecting gene sequence

A gene sequence and gene chip technology, which is applied in the field of devices for detecting gene sequences, can solve the problems of chip price reduction, limitation, and long time, and achieve the effect of improving detection speed.

Inactive Publication Date: 2003-04-09
HAI KANG LIFE
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Problems solved by technology

In addition, the price of polymerase chain reaction detection equipment also limits the application of this technology
Secondly, it takes a long time to pre-amplify samples by polymerase chain reaction, and it is not suitable for on-site use, such as clinics, food, environment or other tests that require extremely high sensitivity
Third, the cost of fluorescent detectors is much higher than that of other types of gene chip detectors
Fourth, the process of electrified force guidance is very time-consuming
The price of chips will be significantly lower, so the price of automatic detection and control instruments will also be significantly lower

Method used

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  • Device and method for detecting gene sequence
  • Device and method for detecting gene sequence
  • Device and method for detecting gene sequence

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Embodiment Construction

[0053] DESCRIPTION OF THE PREFERRED EMBODIMENT

[0054] Preferred embodiments of the present invention are described below with reference to the accompanying drawings.

[0055] Referring to accompanying drawing 1, described a device for detecting gene sequence according to the present invention, wherein the gene chip is placed in the reaction chamber. The figure does not show the reaction chamber, and the electric field application device, the gene sequence (ie sample) adding device and the nanoparticle probe adding device in the reaction chamber. In fact, the electric field can be applied by applying a voltage to the electrodes of the gene chip, or by applying an electrostatic field or an electromagnetic field, and its magnitude is sufficient to make the added gene sequence (ie, the sample) move in a clear direction. The nanoparticle probe is in the form of a solution, and is added to the reaction chamber after the hybridization reaction between the gene chip and the gene se...

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Abstract

The present invention provides a device and a method for detecting gene sequence, combines detecting system based on nano particle principle and electric field device to control and speed micro matrix detection and provides an autoamtic control process via analysis of the feedback signal of nano particle probes on the chip. The present invention also relates to the relevant gene sequence detecting method. The present invention also provides the autoamtic feedback and automatic regulation device and method for the crossing and de-crossing process of the micro matrix gene chip. The present invention has high detection speed, high sensitivity and low cost compared with fluorescent probe method.

Description

field of invention [0001] The present invention relates to a device and a method for detecting gene sequences, more particularly, to a device and a method for detecting gene sequences using an electronic biological gene chip. Background of the invention [0002] DNA gene chips use hundreds, thousands or tens of thousands of single strands of DNA as probes. There are two main types of DNA used: nucleotides and complementary nucleotides (cDNA) already present in gene banks. They are formed on the chip in a high-density dot matrix. [0003] Microarray DNA gene chips are used in the diagnosis of different types of diseases and in the later research of genes in medicine and pharmacology. As long as a microarray biological probe on a chip is used, a large amount of genetic and molecular science data can be processed, especially regarding genetic mutation and expression. This speeds up the process of diagnosing genetic diseases and facilitating the research and development of ne...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
Inventor 于常海王荣彭亮刘乐庭杨于文琴
Owner HAI KANG LIFE
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