Water soluble heteropolysaccharide with anti-tumor activity and its preparing method and use

Abstract

The present invention provides a water soluble tuckahoe mycelium hetero polysaccharide with anti-tumor activity. By using corn slurry as main component to prepare culture medium, tuckahoe, mycelium is cultured through deep fermentation of wild Tuckahoe strain. Water soluble hetereo polysaccharide is extracted from the mycelium with physiological saline and hot water. The hetero polysaccharide consists of alpha-D-glucose, mannitol, galactose and protein in different content. Experiments shows that the hetero polysaccharides can inhibit the growth of Sarcoma 180 tumor in mouse and acute leukovirus cell, so that they may be used as antitumor medicine and health article for raising body's immunological function.

Description

technical field

[0001] The invention relates to a water-soluble heteropolysaccharide with antitumor activity, a preparation method and application thereof. It belongs to the field of natural polymers and also belongs to the field of molecular biology. Background technique

[0002] In the 1970s, due to the progress made in the research of chemical functions of cell membranes, immune substances and new drugs, as well as the discovery of complex polysaccharides such as glycoproteins and glycolipids, polysaccharides have been convinced that polysaccharides have many biological activities. The research of Chihara (J.Immunol.Immunopharmacol., IV, 85, 1983) believes that the activity of polysaccharides is not directly killing cells as in chemotherapy, but there is an indirect anti-tumor activity, that is, it is activated by the immune system. The delivered activity is primarily a stimulation of specific non-specific or specific functions of the immune system and therefore has mini...