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Bone grafting material possessing antiinfection ability and bone forming activity and its preparation method

An osteogenic activity and anti-infection technology, applied in the field of medical bone graft materials, can solve problems such as inability to repair bone defects and refractory absorption

Inactive Publication Date: 2003-09-17
NO 1 AUXILARY HOSPITAL NO 4 MILLITARY MEDICAL UNIV P L A
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  • Summary
  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

But the PMMA bead chain is not a bone graft material, it is difficult for the body to absorb it, it needs to be taken out twice, and it has no osteogenic effect, so it cannot repair bone defects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0014] 1) Select fresh bovine humerus upper cancellous bone, make 3.0mm×3.0mm×3.0mm bone grains, rinse with warm water at 50°C, degrease with 1:1 (ml:ml) chloroform / methanol mixture for 12 hours, 8.8mol / Deproteinize with L hydrogen peroxide for 48 hours, decalcify the surface with 0.6mol / L hydrochloric acid for 5 minutes, and freeze-dry to make antigen-free bovine cancellous bone carrier particles (BCB). The bovine bone morphogenic protein (BMP) extracted according to the Urist method was compounded with BCB under the condition of -93.3kPa, and each BCB was compounded with 1.5mg of bovine BMP, dialyzed against double distilled water at 4°C for 72h, and freeze-dried to make a recombination Bone xenograft (RBX) bone particles.

[0015] 2) In a clean environment at room temperature, weigh 50g of coagulated calcium phosphate powder (CPC), 5g of gentamicin powder, 2.5g of clindamycin powder, and 2.5g of rifampicin powder, and place them in a 250ml clean glass in a beaker. After ...

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PUM

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Abstract

A bone-implanting material with strong anti-infection power and high osteogenic activity is prepared from antigen-removed bone carrier, bone growth factor, antibiotic and self-solidifying slow releasing auxiliary through compounding bone growth factor, immersing in antibiotic slow-releasing agent, wrapping after solidifying, and sterilizing. It has high curative effect to infective bone injury.

Description

technical field [0001] The invention belongs to the technical field of medical bone graft materials, and relates to a bone graft material with strong anti-infection ability and high-efficiency osteogenic activity (hereinafter referred to as anti-infection active bone) and a preparation method thereof. Background technique [0002] For a long time, the treatment of contaminated (or infected) bone defects has been a problem that has not been well resolved in the field of orthopedics. The traditional treatment method is generally: first use debridement (or focus removal) and other surgical methods to remove most of the pathogenic bacteria, and use antibiotics to eliminate the remaining pathogenic bacteria, and wait for 3 to 6 months after the wound is closed and there is no sign of infection. Afterwards, another stage II bone graft repair. In principle, phase I bone grafting is contraindicated. This is because after debridement (or focus removal) of contaminated (or infected)...

Claims

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Application Information

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IPC IPC(8): A61L27/54
Inventor 胡蕴玉袁志刘建李丹栗向东张超孙梁毕龙
Owner NO 1 AUXILARY HOSPITAL NO 4 MILLITARY MEDICAL UNIV P L A
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