Bone grafting material possessing antiinfection ability and bone forming activity and its preparation method

An osteogenic activity and anti-infection technology, applied in the field of medical bone graft materials, can solve problems such as inability to repair bone defects and refractory absorption

Inactive Publication Date: 2003-09-17
NO 1 AUXILARY HOSPITAL NO 4 MILLITARY MEDICAL UNIV P L A
View PDF0 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the PMMA bead chain is not a bone graft material, it is difficult for the body to absorb it,

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0014] 1) Select fresh bovine humerus upper cancellous bone, make 3.0mm×3.0mm×3.0mm bone grains, rinse with warm water at 50°C, degrease with 1:1 (ml:ml) chloroform / methanol mixture for 12 hours, 8.8mol / Deproteinize with L hydrogen peroxide for 48 hours, decalcify the surface with 0.6mol / L hydrochloric acid for 5 minutes, and freeze-dry to make antigen-free bovine cancellous bone carrier particles (BCB). The bovine bone morphogenic protein (BMP) extracted according to the Urist method was compounded with BCB under the condition of -93.3kPa, and each BCB was compounded with 1.5mg of bovine BMP, dialyzed against double distilled water at 4°C for 72h, and freeze-dried to make a recombination Bone xenograft (RBX) bone particles.

[0015] 2) In a clean environment at room temperature, weigh 50g of coagulated calcium phosphate powder (CPC), 5g of gentamicin powder, 2.5g of clindamycin powder, and 2.5g of rifampicin powder, and place them in a 250ml clean glass in a beaker. After ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A bone-implanting material with strong anti-infection power and high osteogenic activity is prepared from antigen-removed bone carrier, bone growth factor, antibiotic and self-solidifying slow releasing auxiliary through compounding bone growth factor, immersing in antibiotic slow-releasing agent, wrapping after solidifying, and sterilizing. It has high curative effect to infective bone injury.

Description

technical field [0001] The invention belongs to the technical field of medical bone graft materials, and relates to a bone graft material with strong anti-infection ability and high-efficiency osteogenic activity (hereinafter referred to as anti-infection active bone) and a preparation method thereof. Background technique [0002] For a long time, the treatment of contaminated (or infected) bone defects has been a problem that has not been well resolved in the field of orthopedics. The traditional treatment method is generally: first use debridement (or focus removal) and other surgical methods to remove most of the pathogenic bacteria, and use antibiotics to eliminate the remaining pathogenic bacteria, and wait for 3 to 6 months after the wound is closed and there is no sign of infection. Afterwards, another stage II bone graft repair. In principle, phase I bone grafting is contraindicated. This is because after debridement (or focus removal) of contaminated (or infected)...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L27/54
Inventor 胡蕴玉袁志刘建李丹栗向东张超孙梁毕龙
Owner NO 1 AUXILARY HOSPITAL NO 4 MILLITARY MEDICAL UNIV P L A
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap