Injection for curing acute lung injury and acute respirotary distress syndrome

A technology for acute respiratory distress and acute lung injury, applied in respiratory diseases, drug combinations, freeze-dried delivery, etc., can solve the problem of decreased hematocrit and hemoglobin, no mutagenic effect of siverelex, increased lung weight, etc. question

Inactive Publication Date: 2003-11-26
HONGYI SCI & TECH CO LTD NANCHANG
View PDF0 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Red blood cells, hematocrit and hemoglobin decreased in both male and female dogs in the 30mg/kg dose group, and the lung weight in male

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example 2

[0165] Sivelestat 100g

[0166] Mannitol 200g

[0167] Polysorbate 80 50g

[0168] Sodium bicarbonate

[0169] Add water for injection to 3000ml

[0170] Divide into 1000 bottles and freeze-dry. Three, example 3

example 3

[0171] Sivelestat 100g

[0172] 200g lactose

[0173] Polysorbate 80 50g

[0174] Sodium carbonate

[0175] Add water for injection to 3000ml

[0176] Divide into 1000 bottles, freeze dried

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The injection preparation for treating acute lung injury and acute respiratory distress syndrome is bacteria-free freeze dried powder for injection with Sivelestat as active component, stuffing frame agent, co-solvent and pH regulator. It has improved water solubility of Sivelestat and improved medicine stability.

Description

Technical field [0001] The invention relates to an injection for the treatment of acute lung injury and acute respiratory distress syndrome, specifically the English name is sivelestat Sodium Hydrate and the chemical name is N-[2-[4-(2,2-dimethylpropionic acid Yl)benzenesulfonamido]benzoyl]aminoacetate·tetrahydrate, the structural formula is The molecular formula is C 20 H 21 N 2 NaO 7 S·4H 2 O, a sterile freeze-dried powder injection with a molecular weight of 528.51 and the Chinese name of sivelestat. technical background [0002] Acute lung injury (ALI) / Acute Respiratory Distress Syndrome (ALI / ARDS) refers to acute and progressive hypoxic respiratory failure caused by various pathogenic factors inside and outside the lungs other than cardiogenic. ALI and ARDS have the same pathophysiological changes, and severe ALI or the final severe stage of ALI is defined as ARDS. The main pathological feature of ALI / ARDS is the formation of protein-rich pulmonary edema and hyaline membran...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/19A61K31/222A61P11/00
Inventor 钱进许军彭红刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap