Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Erigeron breviscapus slow release capsule and its preparation method

A technology of breviscapine and sustained-release capsules, which is applied in the field of traditional Chinese medicine, can solve the problems of tablets being difficult to dissolve in water, poor dissolution rate, and low bioavailability, so as to reduce the number of times of taking, take conveniently, and have high bioavailability Effect

Inactive Publication Date: 2004-03-03
TSINGHUA UNIV
View PDF0 Cites 39 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to propose a novel breviscapine sustained-release dosage form-breviscapine sustained-release capsule and its preparation method, which can overcome the difficult water-soluble, poor dissolution rate and low bioavailability of tablets prepared by traditional techniques Defects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Weigh 25g of polyvinylpyrrolidone and 2g of ethyl cellulose (100:8), put them into 95% ethanol solution to swell, shake, after completely dissolving, add 95% ethanol to prepare polyvinylpyrrolidone for bonding Mix 500ml of ethanol solution with ethyl cellulose.

[0036] (2) Weigh 25g of polyvinylpyrrolidone and 2g of ethyl cellulose (100:8), put them into 95% ethanol solution to swell, shake, after completely dissolving, add 95% ethanol to prepare polyvinylpyrrolidone and Ethyl cellulose mixed with ethanol solution 500ml.

[0037] (3) Weigh the prescription amount of blank ball cores and put them in the coating granulator, according to the parameters in the operating parameter table, evenly add scutellarin powder, and spray the mixed ethanol solution of polyvinylpyrrolidone and ethyl cellulose for bonding at the same time, until After the solution is sprayed, the drug-containing pellets are obtained.

[0038] (4) In the same coating granulator, according to the pa...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A slow-releasing Erigeron breviscapus capsule for treating coronary heart disease, angine pectoris and myocardial infarction is prepared through putting the empty pill core in granulating machine, adding breviscapine, spraying adhesive, granulating, and coating. Said adhesive and coating are prepared from polyvinyl pyrrolidone and ethylcellulose.

Description

technical field [0001] The invention relates to a medicinal dosage form of breviscapine, in particular to a sustained-release capsule of breviscapine and a preparation method thereof, which is a good form of medicine for the treatment and prevention of stroke paralysis, coronary heart disease, angina pectoris and other diseases, and belongs to traditional Chinese medicine technology field. Background technique [0002] The active ingredient scutellarin in the capsule is extracted and refined from Yunnan specialty medicinal material Erigeronbreviscapusvaut (Hand Mazz), which has the functions of dilating microvessels, improving microcirculation, reducing blood viscosity, inhibiting platelet aggregation, Promote fibrinolysis, prevent thrombolysis, increase tissue perfusion, scavenge free radicals, lower blood fat, lower blood sugar, etc. Since the 1980s, Yunnan Biopharmaceutical Factory, Yunnan Institute of Materia Medica, Yunnan Gejiu Biopharmaceutical Factory and many other...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/7048A61P9/10
Inventor 罗国安王义明饶毅曹进魏惠珍
Owner TSINGHUA UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com