Erigeron breviscapus slow release capsule and its preparation method

A technology of breviscapine and sustained-release capsules, which is applied in the field of traditional Chinese medicine, can solve the problems of tablets being difficult to dissolve in water, poor dissolution rate, and low bioavailability, so as to reduce the number of times of taking, take conveniently, and have high bioavailability Effect

Inactive Publication Date: 2004-03-03
TSINGHUA UNIV
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  • Summary
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Problems solved by technology

[0003] The purpose of the present invention is to propose a novel breviscapine sustained-release dosage form-breviscapine sustained-release capsule and its prepar

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Weigh 25g of polyvinylpyrrolidone and 2g of ethyl cellulose (100:8), put them into 95% ethanol solution to swell, shake, after completely dissolving, add 95% ethanol to prepare polyvinylpyrrolidone for bonding Mix 500ml of ethanol solution with ethyl cellulose.

[0036] (2) Weigh 25g of polyvinylpyrrolidone and 2g of ethyl cellulose (100:8), put them into 95% ethanol solution to swell, shake, after completely dissolving, add 95% ethanol to prepare polyvinylpyrrolidone and Ethyl cellulose mixed with ethanol solution 500ml.

[0037] (3) Weigh the prescription amount of blank ball cores and put them in the coating granulator, according to the parameters in the operating parameter table, evenly add scutellarin powder, and spray the mixed ethanol solution of polyvinylpyrrolidone and ethyl cellulose for bonding at the same time, until After the solution is sprayed, the drug-containing pellets are obtained.

[0038] (4) In the same coating granulator, according to the pa...

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Abstract

A slow-releasing Erigeron breviscapus capsule for treating coronary heart disease, angine pectoris and myocardial infarction is prepared through putting the empty pill core in granulating machine, adding breviscapine, spraying adhesive, granulating, and coating. Said adhesive and coating are prepared from polyvinyl pyrrolidone and ethylcellulose.

Description

technical field [0001] The invention relates to a medicinal dosage form of breviscapine, in particular to a sustained-release capsule of breviscapine and a preparation method thereof, which is a good form of medicine for the treatment and prevention of stroke paralysis, coronary heart disease, angina pectoris and other diseases, and belongs to traditional Chinese medicine technology field. Background technique [0002] The active ingredient scutellarin in the capsule is extracted and refined from Yunnan specialty medicinal material Erigeronbreviscapusvaut (Hand Mazz), which has the functions of dilating microvessels, improving microcirculation, reducing blood viscosity, inhibiting platelet aggregation, Promote fibrinolysis, prevent thrombolysis, increase tissue perfusion, scavenge free radicals, lower blood fat, lower blood sugar, etc. Since the 1980s, Yunnan Biopharmaceutical Factory, Yunnan Institute of Materia Medica, Yunnan Gejiu Biopharmaceutical Factory and many other...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/10
Inventor 罗国安王义明饶毅曹进魏惠珍
Owner TSINGHUA UNIV
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