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Erigeron breviscapus slow release capsule and its preparation method

A technology of breviscapine and sustained-release capsules, which is applied in the field of traditional Chinese medicine, can solve the problems of low bioavailability, difficulty in dissolving tablets in water, and poor dissolution rate, etc., and achieve high bioavailability, reduced taking times, and convenient taking Effect

Inactive Publication Date: 2005-06-15
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to propose a novel breviscapine sustained-release dosage form-breviscapine sustained-release capsule and its preparation method, which can overcome the difficulty of dissolving in water, poor dissolution rate and low bioavailability of tablets prepared by traditional techniques Defects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Weigh 25g of polyvinylpyrrolidone and 2g of ethyl cellulose (100:8), put them into 95% ethanol solution to swell, shake, after completely dissolving, add 95% ethanol to prepare polyvinylpyrrolidone for bonding Mix 500ml of ethanol solution with ethyl cellulose.

[0036] (2) Weigh 25g of polyvinylpyrrolidone and 2g of ethyl cellulose (100:8), put them into 95% ethanol solution to swell, shake, after completely dissolving, add 95% ethanol to prepare polyvinylpyrrolidone and Ethyl cellulose mixed with ethanol solution 500ml.

[0037] (3) Weigh the prescription amount of blank ball cores and put them in the coating granulator, according to the parameters in the operating parameter table, evenly add scutellarin powder, and spray the mixed ethanol solution of polyvinylpyrrolidone and ethyl cellulose for bonding at the same time, until After the solution is sprayed, the drug-containing pellets are obtained.

[0038] (4) In the same coating granulator, according to the pa...

Embodiment 2

[0042] (1) Weigh 25g of polyvinylpyrrolidone and 1.5g of ethyl cellulose (100:6), put them into 95% ethanol solution to swell, shake, after completely dissolving, add 95% ethanol to prepare polyethylene for bonding Pyrrolidone and ethyl cellulose mixed ethanol solution 500ml.

[0043] (2) Weigh 25g of polyvinylpyrrolidone and 2.5g of ethyl cellulose (100:10), put them into 95% ethanol solution to swell, shake, after completely dissolving, add 95% ethanol to prepare polyvinylpyrrolidone for sealing Mix 500ml of ethanol solution with ethyl cellulose.

[0044] (3) Weigh the prescription amount of blank ball cores and put them in the coating granulator, according to the parameters in the operating parameter table, evenly add scutellarin powder, and spray the mixed ethanol solution of polyvinylpyrrolidone and ethyl cellulose for bonding at the same time, until After the solution is sprayed, the drug-containing pellets are obtained.

[0045] (4) In the same coating granulator, accor...

Embodiment 3

[0049] (1) Weigh 25g of polyvinylpyrrolidone and 1g of ethyl cellulose (100:4), put them into 95% ethanol solution to swell, shake, after completely dissolving, add 95% ethanol to prepare polyvinylpyrrolidone for bonding Mix 500ml of ethanol solution with ethyl cellulose.

[0050] (2) Weigh 25g of polyvinylpyrrolidone and 3g of ethyl cellulose (100:12), put them into 95% ethanol solution to swell, shake, after completely dissolving, add 95% ethanol to prepare polyvinylpyrrolidone and Ethyl cellulose mixed with ethanol solution 500ml.

[0051] (3) Weigh the prescription amount of blank ball cores and put them in the coating granulator, according to the parameters in the operating parameter table, evenly add scutellarin powder, and spray the mixed ethanol solution of polyvinylpyrrolidone and ethyl cellulose for bonding at the same time, until After the solution is sprayed, the drug-containing pellets are obtained.

[0052] (4) In the same coating granulator, according to the p...

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Abstract

The breviscapine sustained-release capsule and a preparation method thereof relate to a medicinal dosage form and a preparation process of a traditional Chinese medicine breviscapine sustained-release capsule. Capsules include the active ingredient scutellarin, blank ball cores and adhesives for adhering scutellarin powder to the blank cores and a coating layer for surface sealing. The adhesive and coating layers are made of polyvinylpyrrolidone Composed of ethyl cellulose, each capsule contains 60mg of breviscapine. During the preparation, the blank ball core is put into a coating granulator, scutellarin powder is added, and an adhesive is sprayed at the same time to make medicine-containing pellets, which are then sealed on the surface to make slow-release capsules. The present invention overcomes the disadvantages of poor dissolution rate and short drug action time of the original tablet form, can reach the required effective blood drug concentration in a short period of time, and can maintain the required blood drug concentration in a long period of time. High, reducing the daily dosage and frequency, only need to take twice a day, one capsule each time, it is a good maintenance drug for patients with coronary heart disease, angina pectoris, myocardial infarction and so on.

Description

technical field [0001] The invention relates to a medicinal dosage form of breviscapine, in particular to a sustained-release capsule of breviscapine and a preparation method thereof, which is a good form of medicine for the treatment and prevention of stroke paralysis, coronary heart disease, angina pectoris and other diseases, and belongs to traditional Chinese medicine technology field. Background technique [0002] The active ingredient scutellarin in the capsule is extracted and refined from Yunnan specialty medicinal material Erigeronbreviscapusvaut (Hand Mazz), which has the functions of dilating microvessels, improving microcirculation, reducing blood viscosity, inhibiting platelet aggregation, Promote fibrinolysis, prevent thrombolysis, increase tissue perfusion, scavenge free radicals, lower blood fat, lower blood sugar, etc. Since the 1980s, Yunnan Biopharmaceutical Factory, Yunnan Institute of Materia Medica, Yunnan Gejiu Biopharmaceutical Factory and many other...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P9/10
Inventor 罗国安王义明饶毅曹进魏惠珍
Owner TSINGHUA UNIV
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