Injection formulation of astragalus root saponin and its preparation mehod
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A glycoside injection, technology of total astragalus glycosides, applied in the field of medicine, can solve the problems of poor water solubility of total astragalus glycosides, many impurities, difficult to obtain stable and satisfactory preparations and the like
Inactive Publication Date: 2004-03-17
SHANGHAI JINGFENG PHARMA +1
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Abstract
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Problems solved by technology
[0003] The content of total astragalosides in Astragalus injection currently used clinically is not high, and the difference is large, and the drug effect is not easy to control; at the same time, because the content is not high and there are many impurities, patients have many adverse reactions after taking medicine, esp
Method used
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Embodiment 1
[0043] Embodiment 1 (small injection);
[0044] Component Quantity (g / bottle)
[0045] Astragalus total extract (calculated as total astragalosides) 0.02
[0046] Ethanol 0.50
[0047] Propylene glycol 0.40
[0048] Glycerin 0.10
[0049] Mannitol 0.03 preparation process is:
[0050] Take total astragalosides, add mannitol, add ethanol, glycerin and propylene glycol to dissolve, filter and sterilize, subpackage and seal, and sterilize to obtain.
Embodiment 2
[0051] Embodiment 2 (powder injection);
[0052] Component Quantity (g / bottle)
[0053] Astragalosides 0.01
[0054] Mannitol 0.03 preparation process is:
[0055] Take total astragalosides, add mannitol, add 20ml of water, heat to dissolve, weigh hot filter to sterilize, sub-package, and freeze-dry to obtain.
Embodiment 3
[0056] Embodiment 3 (powder injection)
[0057] Component Quantity (g / bottle)
[0058] Astragalosides 0.03
[0059] The preparation process of lactose 0.05 is:
[0060] Take total astragalosides, lactose, add 10ml of ethanol, dissolve, filter and sterilize, spray dry, aseptically sub-package, and press the cap to get it.
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Abstract
The present invention is general astragaloside injection and its preparation process. The present invention screens some co-solvent and co-solving diluent including propylene glycol, ethanol, glycerine, polyglycol, benzyl benzoate, dimethyl acetamide, etc. to increase the dissolubility of general astragaloside in water. Each injection contains general astragaloside 5-50 mg, and medicinal supplementary material including diluent, co-solvent, excipient, osmotic pressure regulator, etc. The present invention has determined curative effect.
Description
technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical preparation of total astragalosides, more specifically to a kind of injection of total astragalosides (including small injections, powder injections, glucose infusion and sodium chloride infusion). It relates to a preparation method of the preparation. Background technique [0002] Astragalus is a traditional traditional Chinese medicine that invigorates qi and strengthens the surface, diuretics and toxins, drains pus, and suppresses sores and promotes granulation. A large number of studies have shown that the active ingredient of Astragalus is total glycosides of Astragalus. Traditional Chinese medicine believes that qi stagnation and blood stasis are one of the main causes of cardiovascular and cerebrovascular diseases. Astragalosides are used to treat qi stagnation and blood stasis cardiovascular and cerebrovascular diseases, and the curative effe...
Claims
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Application Information
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