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Use of alkaloid compounds in preparing medicine

A technology of compounds and alkaloids, applied in the field of medicine, can solve the problems of addiction, dependence, inability to use for a long time, etc., and achieve good analgesic effect without dependence.

Inactive Publication Date: 2004-06-30
湖南隆来福生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the biggest disadvantage of this drug is that it cannot be used for a long time, otherwise, it will cause dependence or addiction

Method used

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  • Use of alkaloid compounds in preparing medicine
  • Use of alkaloid compounds in preparing medicine
  • Use of alkaloid compounds in preparing medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Grind 40kg of the Anluo Xiaopi umbrella medicinal material into the coarsest powder, add ethanol and reflux 3 times, add 8 times the amount to extract for 2 hours each time, combine the filtrates, combine under reduced pressure, reclaim ethanol under reduced pressure, and obtain about 6kg (relative density about 1.20 -1.25, heat measurement at 60°C), add 10 times the amount of water to dilute, add concentrated ammonia water to adjust PH8-9, add petroleum ether 5 times, recover petroleum ether, add chloroform 5 times, recover chloroform, and get a thick paste of about 1kg (relative density 1.35-1.38, thermal measurement at 60°C), add about 5kg of silica gel H: diatomaceous earth (2:1), mix well, dry, and put on the silica gel H column [silica gel H: diatomaceous earth (2:1), acetone wet method on the column ], add acetone to elute, collect the acetone eluate until the color is very light (the amount of extract is less), recover acetone, and get a thick paste (about 0.5kg,...

Embodiment 2

[0074] Grind 40 kg of Anluo Xiaopi umbrella medicinal material into the coarsest powder, add ethanol to reflux 3 times, add 8 times the amount to extract for 2 hours each time, combine the filtrates, recover ethanol under reduced pressure, and obtain about 6 kg (relative density is about 1.20-1.25, 60 ℃ heat measurement), add 10 times the amount of water to dilute, add concentrated ammonia water to adjust the pH to 8-9, add petroleum ether 5 times, recover petroleum ether, add chloroform 5 times, recover chloroform, and obtain a thick paste of about 1kg with a relative density of 1.35-1.38, 60 ℃ thermal measurement), add about 5kg of silica gel H: diatomaceous earth (2:1), mix well, dry, put on the silica gel H column [silica gel H: diatomaceous earth (2:1), acetone wet column], collect acetone Eluate until the color is very light (the amount of extract is less), recover acetone to obtain a thick paste (about 0.5kg, relative density 1.35-1.38, thermal test at 60°C), add ethyl a...

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Abstract

The present invention relates to a small molecular weight alkaloid compound I whose molecular formula is C9H17NO and molecular weight is 155 and its application in preparation of medicine for stopping pain. The tests show that said compound has good paint-stopping effect, and has no effective component producing dependence.

Description

Technical field: [0001] The present invention relates to the use of alkaloid compounds, in particular to the use in the field of medicine. Background technique: [0002] Many analgesic drugs have been developed. Drugs with better analgesic effects include morphine and pethidine. This is the most effective analgesic drug currently in clinical use. However, the biggest disadvantage of this drug is that it cannot be used for a long time, otherwise, dependence or addiction will occur. Therefore, when people use this type of medicine, they need to be very cautious to avoid the above-mentioned side effects. Invention content: [0003] The present invention refers to providing an alkaloid compound capable of solving the above-mentioned technical problems. [0004] Compound I provided by the present invention has the following structural formula [0005] [0006] Molecular formula is C 9 h 17 NO, with a molecular weight of 155, is a white needle crystal. The compound ca...

Claims

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Application Information

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IPC IPC(8): A61K31/45A61P25/04
Inventor 高守泉谢昭明李勇敏朱绍雄王晓洪唐正平杨明
Owner 湖南隆来福生物工程有限公司
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