Hemostatic wound dressing and its producing method

A technology for wound dressings and hemostatic agents, which is used in pharmaceutical formulations, other medical devices, knitting, etc.

Inactive Publication Date: 2004-09-29
ETHICON INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unbound reagents may migrate into the blood stream, which is undesirable

Method used

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  • Hemostatic wound dressing and its producing method
  • Hemostatic wound dressing and its producing method
  • Hemostatic wound dressing and its producing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0136] Preparation of carboxylated oxidized regenerated cellulose (CORC) / HEC porous membrane:

[0137] 1 gram of carboxyethylcellulose (HEC, from Aldrich) was dissolved in 99 grams of deionized water. After the polymer was completely dissolved, 10 grams of the HEC solution was transferred into a crystallization dish with a diameter of 10 cm. A piece of CORC-based Surgicel Nu-Knit(R) absorbable hemostat, 9.8 cm in diameter (approximately 1.3 grams), was placed on top of the HEC solution in the crystallization tray. After soaking the fabric in the solution for 3 minutes, the wet fabric in the tray was then subjected to lyophilization overnight. Forms a very flexible diaphragm. The membrane was further dried under vacuum at room temperature.

Embodiment 2

[0139] Preparation of CORC / CS porous membrane:

[0140] 1 gram of cellulose sulfate (CS, from ACROS Organics) was dissolved in 99 grams of deionized water. After the polymer was completely dissolved, 10 grams of the CS solution was transferred into a crystallization dish with a diameter of 10 cm. A piece of Surgicel Nu-Knit(R) absorbable hemostat, 9.8 cm in diameter (approximately 1.3 grams), was placed on top of the CS solution in the crystallization tray. After soaking the fabric in the solution for 3 minutes, the wet fabric in the tray was then subjected to lyophilization overnight. Forms a very flexible diaphragm. The membrane was further dried under vacuum at room temperature.

Embodiment 3

[0142] Preparation of CORC / MC porous membrane:

[0143] 1 gram of methylcellulose (MC, from Aldrich) was dissolved in 99 grams of deionized water. After the polymer was completely dissolved, 10 grams of the MC solution was transferred into a crystallization dish with a diameter of 10 cm. A piece of Surgicel Nu-Knit(R) absorbable hemostat, 9.8 cm in diameter (approximately 1.3 grams), was placed on the MC solution in the crystallization tray. After soaking the fabric in the solution for 3 minutes, the wet fabric in the tray was then subjected to lyophilization overnight. Forms a very flexible diaphragm. The membrane was further dried under vacuum at room temperature.

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Abstract

The present invention is directed to a hemostatic wound dressing that utilizes a fibrous, fabric substrate made from carboxylic-oxidized cellulose and containing a first surface and a second surface opposing the first surface, the fabric having flexibility, strength and porosity effective for use as a hemostat; and further having a porous, polymeric matrix substantially homogeneously distributed on the first and second surfaces and through the fabric, the porous, polymeric matrix being made of a biocompatible, water-soluble or water-swellable cellulose polymer, wherein prior to distribution of the polymeric matrix on and through the fabric, the fabric contains about 3 percent by weight or more of water-soluble oligosaccharides.

Description

[0001] This application is U.S. Patent Application Serial No. 10 / 186021, filed June 28, 2002, U.S. Patent Application Attorney Docket No. ETH5010, filed November 26, 2002, U.S. Patent Application Attorney Docket No. ETH5011, filed November 26, 2002 Continuation-in-Part of US Patent Application Attorney Docket No. ETH5012, filed November 26, 2002, and US Patent Application Attorney Docket No. ETH5014, filed December 20, 2002. technical field [0002] The present invention relates to hemostatic wound dressings comprising a textile substrate and a porous, water-soluble or water-swellable polymer matrix arranged on and in said substrate, and to the production of such hemostatic wound dressings Methods of Wound Dressing. technical background [0003] During surgical procedures, control of bleeding is very important and critical to minimize blood loss, reduce post-operative complications, and shorten surgical time in the oper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/00A61L15/28A61L15/42A61L15/64A61L27/20C08L1/04C08L1/16C08L1/28C08L5/08
CPCC08L1/284A61L15/28A61L2400/04Y10T442/2525C08L5/08C08L1/16D04B21/16C08L1/04D10B2509/022A61L15/425D10B2509/08A61L27/20A61L15/64C08L2666/26C08L5/00C08L1/02C08L1/24
Inventor D·L·罗尼J·X·郭G·张S·M·彭哈卡A·J·戈曼T·L·克拉文M·伯梅尔
Owner ETHICON INC
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