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Dolysaccharide nanometer anticancer material and its preparation method

A nanotechnology of polysaccharides and chitosan, which is applied in the direction of antineoplastic drugs, pharmaceutical formulas, and medical preparations of non-active ingredients, etc., and can solve problems such as low yield, large nanoparticle size, and uneven particle size. problem, to achieve the effect of good shape and uniform particle size

Inactive Publication Date: 2005-01-05
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the particle size of the above-mentioned nanoparticles is generally large, the yield is low, and the particle size of the formed particles is not uniform.

Method used

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  • Dolysaccharide nanometer anticancer material and its preparation method
  • Dolysaccharide nanometer anticancer material and its preparation method
  • Dolysaccharide nanometer anticancer material and its preparation method

Examples

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example 1

[0029] Under magnetic stirring at 20°C, add chitosan with a molecular weight of 9kDa and a deacetylation degree of 85% to 0.5% acetic acid solution, prepare a 0.1% chitosan acid solution, and add 0.1% sodium polyphosphate solution to the chitosan acetic acid solution , after the reaction is complete, centrifuge at 3000rpm / min, rinse the precipitate with distilled water until neutral, and then freeze-dry to obtain the polysaccharide nano-anticancer material.

[0030] The average particle size of the nanoparticles prepared by the above-mentioned method is about 50nm, and the perspective electron micrograph shows that the nanoparticles are a more regular spherical structure (see figure 1 ), can be stored stably at pH 3-8.

example 2

[0032] Under magnetic stirring at 60°C, add chitosan with a molecular weight of 10kDa and a deacetylation degree of 84% to 0.5% acetic acid solution, prepare a 5% chitosan acid solution, and add 5% sodium sulfate solution to the chitosan acetic acid solution to form Microemulsion, centrifuged at 4000rpm / min, rinsed with distilled water until neutral, freeze-dried to obtain chitosan nanoparticles, put the dry powder of chitosan nanoparticles in 600mg / L cobalt ion solution, oscillate at 300rpm / min for adsorption, after the adsorption is complete and put the adsorbed chitosan nano-particles in an oven to dry at 60° C. to obtain the polysaccharide nano anti-cancer material.

[0033] The cobalt-loaded nanoparticles average particle diameter prepared by the above method is about 60nm, wherein the cobalt content is about 10%, and the atomic force microscope shows that the nanoparticles are a more regular spherical structure (see figure 2 ), can be stored stably at pH 3-8.

example 3

[0035] Under magnetic stirring at 30°C, add chitosan with a molecular weight of 8kDa and a deacetylation degree of 86% to 1% hydrochloric acid solution, prepare a 2% chitosan acid solution, and add 1% sodium citrate solution to the chitosan acetic acid solution, After the reaction is complete, centrifuge at 6000rpm / min, rinse the sediment with distilled water until neutral, and freeze-dry to obtain the polysaccharide nano-anticancer material.

[0036] The average particle size of the nanoparticles prepared by the above method is about 70nm, and the atomic force microscope shows that the nanoparticles are spherical structures (see image 3 ), can be stored stably at pH 3-8.

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Abstract

A nano-class anticancer polyose material for treating stomach cancer, intestine cancer and liver cancer is prepared from chitosan as basic raw material.

Description

technical field [0001] The invention relates to a polysaccharide nano anti-cancer material based on chitosan and a preparation method thereof. Background technique [0002] Chitosan is a natural polymer bio-oligomer, and its degradation product is weakly alkaline glucosamine, which is non-toxic and harmless to human tissues. In addition to its excellent biocompatibility, it also has unique biological activity, which can regulate animal body immunity, inhibit tumor cell proliferation, has strong antibacterial activity, and can regulate cholesterol and lipid metabolism in animals. As a feed additive, heavy metal chelating agent, adsorbent, drug slow-release agent and other functional materials, chitosan has been used in agriculture, industry and medicine. A variety of chitosan modified products, such as cross-linked chitosan, chitosan microspheres, chitosan nanoparticles, etc. have also been well used. Chitosan microspheres and beaded chitosan have...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/722A61K47/36A61P35/00
CPCA61K31/722A61P35/00
Inventor 许梓荣亓立峰胡彩虹夏枚生
Owner ZHEJIANG UNIV
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