Dolysaccharide nanometer anticancer material and its preparation method
A nanotechnology of polysaccharides and chitosan, which is applied in the direction of antineoplastic drugs, pharmaceutical formulas, and medical preparations of non-active ingredients, etc., and can solve problems such as low yield, large nanoparticle size, and uneven particle size. problem, to achieve the effect of good shape and uniform particle size
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
example 1
[0029] Under magnetic stirring at 20°C, add chitosan with a molecular weight of 9kDa and a deacetylation degree of 85% to 0.5% acetic acid solution, prepare a 0.1% chitosan acid solution, and add 0.1% sodium polyphosphate solution to the chitosan acetic acid solution , after the reaction is complete, centrifuge at 3000rpm / min, rinse the precipitate with distilled water until neutral, and then freeze-dry to obtain the polysaccharide nano-anticancer material.
[0030] The average particle size of the nanoparticles prepared by the above-mentioned method is about 50nm, and the perspective electron micrograph shows that the nanoparticles are a more regular spherical structure (see figure 1 ), can be stored stably at pH 3-8.
example 2
[0032] Under magnetic stirring at 60°C, add chitosan with a molecular weight of 10kDa and a deacetylation degree of 84% to 0.5% acetic acid solution, prepare a 5% chitosan acid solution, and add 5% sodium sulfate solution to the chitosan acetic acid solution to form Microemulsion, centrifuged at 4000rpm / min, rinsed with distilled water until neutral, freeze-dried to obtain chitosan nanoparticles, put the dry powder of chitosan nanoparticles in 600mg / L cobalt ion solution, oscillate at 300rpm / min for adsorption, after the adsorption is complete and put the adsorbed chitosan nano-particles in an oven to dry at 60° C. to obtain the polysaccharide nano anti-cancer material.
[0033] The cobalt-loaded nanoparticles average particle diameter prepared by the above method is about 60nm, wherein the cobalt content is about 10%, and the atomic force microscope shows that the nanoparticles are a more regular spherical structure (see figure 2 ), can be stored stably at pH 3-8.
example 3
[0035] Under magnetic stirring at 30°C, add chitosan with a molecular weight of 8kDa and a deacetylation degree of 86% to 1% hydrochloric acid solution, prepare a 2% chitosan acid solution, and add 1% sodium citrate solution to the chitosan acetic acid solution, After the reaction is complete, centrifuge at 6000rpm / min, rinse the sediment with distilled water until neutral, and freeze-dry to obtain the polysaccharide nano-anticancer material.
[0036] The average particle size of the nanoparticles prepared by the above method is about 70nm, and the atomic force microscope shows that the nanoparticles are spherical structures (see image 3 ), can be stored stably at pH 3-8.
PUM
| Property | Measurement | Unit |
|---|---|---|
| Particle size | aaaaa | aaaaa |
| The average particle size | aaaaa | aaaaa |
| The average particle size | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to view more - R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap