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Cytokine-inducing material and cytokine-inducing tool

A technology of cytokines and inducers, applied in the field of cytokine-inducing materials and devices, can solve the problem of not providing a description of cytokine induction.

Inactive Publication Date: 2005-02-16
SEKISUI CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These prior art documents do not provide a description of cytokine induction

Method used

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  • Cytokine-inducing material and cytokine-inducing tool

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] The induction enhancer-1 (synthetic aromatic adsorbent, Mitsubishi Chemical Corp. product, product name: DIAIONHP-50). Then, the induction enhancer-1 was decanted with physiological saline for injection (product of Otsuka Pharmaceutical Co., Ltd.). Then, particle induction enhancer-1 with a bulk volume of 50 μL was packaged in a sterile tube (product of DIATRON Corp., microcentrifuge (Eppendorf) tube with a capacity of 1.5 ml).

[0066] Blood was collected from a healthy person to prepare venous blood containing 15 IU / ml heparin. BCG (product of Japan BCG Manufacturing Co., Ltd.) was added at a concentration of 1 mg / mL of blood. Here, BCG was prepared with physiological saline. The volume ratio of physiological saline to blood was 1.25%.

[0067] About 1.45 mL of BCG-containing blood was introduced into the tube packed with Induction Enhancer-1.

[0068] The tube was inverted to stir the blood, and then a rotary stirrer (product of Taitech Corp.) was installed, whi...

Embodiment 2

[0076] The duration of incubation at 37°C was changed from 24 hours to 4 hours. In other respects, the procedure in Example 1 was followed to obtain cryopreserved plasma. Then, the cryopreserved plasma was thawed, and the amount of TNF-α induced in the plasma was determined using Human TNF-α ELISA kit (product of R&D Systems). The results are shown in Table 2 below.

Embodiment 3

[0083] The total volume of induction enhancer-1 was changed from 50 μL to 5 μL and 1.495 mL was added to the blood. Otherwise, the procedure of Example 1 was followed to determine the amount of induced IFN-γ in plasma. The results are shown in Table 3 below.

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Abstract

A cytokine-inducing material and a cytokine-inducing instrument to be used in cytokine-induction therapy and the like. More specifically speaking, a cytokine-inducing material characterized by containing a water-insoluble induction potentiator comprising a cytokine-inducer such as BCG, a polymer, etc.; and a cytokine-inducing instrument having this inducing material packed in a container. By bringing the inducing material into contact with, for example, blood or blood components, cytokine can be induced more effectively than conventional cases.

Description

technical field [0001] The present invention relates to a cytokine-inducing material and a device used in cytokine-inducing therapy, and more specifically, to a cytokine-inducing material and a device capable of efficiently inducing cytokines. Background technique [0002] Cytokine is a general term for a variety of factors used in various cellular signal transductions. Examples of cytokines include: interferon-α, interferon-β, interferon-γ (IFN-γ), interleukin-1, interleukin-18, tumor necrosis factor-α (Tumor Necrosis Factor-α, TNF-α), tumor Necrosis factor-β (Tumor Necrosis Factor-β), transforming growth factor-α (Transforming Growth Factor-α), transforming growth factor-β (Transforming Growth Factor-β, TGF-β) and various cell growth factors (Special 1995 number of Clinical Immunity Vol. 27, "All about cytokines", Kagaku Hyoron-sha, Clinical Immunity Vol. 36, 39-44, 2001). [0003] Cytokines are known to exhibit various activities in vivo and to be involved in various di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K47/48A61K47/32A61K47/34A61K47/38A61K35/74A61P43/00A61K31/00A61K31/717A61K31/745A61K31/765A61K31/78A61K31/785A61K35/744
CPCA61K31/785A61K31/717A61K47/38A61K31/78A61K35/744A61K31/745A61K47/32A61K31/765A61P43/00A61K47/50
Inventor 新村和夫阿部佳子栗山澄
Owner SEKISUI CHEM CO LTD
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