Bibenzyl compound plagiochin E and its extraction separation method and application

The technology of a compound and featherin, which is applied in the field of bibenzyl compounds and their extraction and separation, can solve the problem of less antifungal compounds, and achieve the effect of novel structure and good application prospect.

Inactive Publication Date: 2005-08-24
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, due to the lack of antifungal compounds from natural sources, people have done a lot of work in the development of new drugs and the use of natural raw materials to extract new drugs,

Method used

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  • Bibenzyl compound plagiochin E and its extraction separation method and application
  • Bibenzyl compound plagiochin E and its extraction separation method and application
  • Bibenzyl compound plagiochin E and its extraction separation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The ground money (Marchantia polymorpa L.) collected from the area of ​​1000-1500 meters above sea level in Mount Emei, Sichuan Province was naturally dried and crushed to 8.95Kg, soaked in 8 times the volume of ground money in ether at 28°C for 5 days, filtered under normal pressure, collected ether and extracted Liquid I, repeated 4 times, combined extract I. Soak the medicinal dregs after the last extraction with 3 times the amount of methanol at 28°C for 4 times, each time for 3 days, filter under normal pressure, collect the methanol extracts, combine them, and concentrate under reduced pressure (vacuum degree 0.09Mpa) in a rotary evaporator at 60°C To obtain the methanol extract, extract the extract 3 times with ether equivalent to 3 times the amount of the extract, collect and combine the ether extract II, combine the two parts of the ether solution I and II, and then distill at 60°C to a fluid extract. Evaporate to dryness to obtain the total ether extract. Mix...

Embodiment 2

[0045] Naturally dry and crush Marchantia polymorpa L. collected from Emei Mountain, Sichuan Province, at an altitude of 1000-1500 meters to obtain 9.50Kg, soak in ether at 23°C for 4 days at 5 times the volume of Marchantia, filter under normal pressure, and collect ether for extraction. Solution I, repeated 6 times, combined extract I; soaked the medicinal dregs after the last extraction with 2 times the amount of methanol at 35°C for 5 times, each time for 2 days, filtered under normal pressure, collected methanol extracts, combined, and used a rotary evaporator Concentrate at 70°C under reduced pressure (vacuum degree 0.09Mpa) to obtain the methanol extract, extract the extract 4 times with ether equivalent to 2 times the amount of the extract, collect and combine the ether extract H, and combine the two parts of the ether solution I and II Afterwards, it was distilled at 70°C to a liquid extract, and evaporated to dryness naturally to obtain the total ether extract. Mix t...

Embodiment 3

[0047] Naturally dry and crush the picked Marchantia polymorpa L. to obtain 8.25Kg, soak 10 times the volume of Marchantia polymorpa in ether at 35°C for 7 days, filter under normal pressure, collect the ether extract I, repeat 3 times, and combine the extract I . Soak the medicinal dregs after the last extraction with 4 times the amount of methanol at room temperature for 3 times, each time for 2 days, filter under normal pressure, collect the methanol extracts, combine them, and concentrate on a rotary evaporator at 50°C under reduced pressure (vacuum degree 0.09Mpa) to obtain For the methanol extract, extract the extract twice with ether equivalent to 5 times the amount of the extract, collect and combine the ether extract II, combine the two parts of the ether solution I and II, and distill at 50°C to a liquid extract, and let it evaporate naturally. Dry to obtain the total ether extract. Mix the above-mentioned ether total extract with 3 times the amount of 300 mesh sili...

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Abstract

A plagiochin E, its extracting and separating process, and its application in preparing antifunga medicines are disclosed.

Description

technical field [0001] The present invention relates to a bibenzyl compound and its extraction and separation method and application thereof, in particular to a bibenzyl compound pallagiochin E (Plagiochin E) and its extraction and separation method from Mossia genus Plantae and its application. Application in the preparation of antifungal drugs. Background technique [0002] Bibenzyl compounds are more common in bryophytes, structurally with C 6 -C 2 -C 6 The mother nucleus and its dimers exist, and are divided into different structural types based on the connection between the benzene rings, usually named according to the plant source; due to the different substituents of the benzene rings, many compounds are produced, named in turn according to the structural type they belong to. Such as dichantin B-H, J-L, phylloxin C, isophylloidin C, etc. (Susanne F., Ulrich HM., Brigirl DN., et al Biosynthesis of Cyclic Bisbibenzyls in Marchantia polymorpha. Phytochemistry, 2001, 5...

Claims

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Application Information

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IPC IPC(8): A61K31/04A61K31/10A61K31/335C07C313/00
Inventor 娄红祥牛冲范培红
Owner SHANDONG UNIV
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