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Traditional Chinese medicinal preparation for treating chronic bronchitis, its preparation method and application

A technology for chronic bronchitis and traditional Chinese medicine preparations, which can be applied in medical formulas, medical preparations containing active ingredients, drug delivery, etc., and can solve problems such as reports of undiscovered ophiopogon saponin D preparations, etc.

Inactive Publication Date: 2005-10-26
张海峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Did not find any report of Ophioside D preparation in the data search

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] (1) Take Radix Ophiopogon japonicus medicinal material, dry and grind at low temperature, use 4 times the amount of 70% ethanol to reflux extract twice, each time for 1 hour, combine the reflux liquid, recover ethanol under reduced pressure, add 4 times the amount of distilled water to suspend, and use petroleum ether Extraction, the aqueous solution is then extracted 3 times with water-saturated n-butanol, the n-butanol extract is decompressed to recover n-butanol, adsorbed on a macroporous adsorption resin, eluted with water, 20% ethanol, and 70% ethanol respectively, and collect 5 times the amount 70% ethanol eluent, recover ethanol, adsorb on alumina column, wash with water until colorless, then elute with 6 times the amount of 60% ethanol, recover ethanol from eluent, and apply water-ethanol system gradient for HPLC preparative chromatography Separation and detection, collection of 80% ethanol eluted part, namely the ophioposide D of the present invention;

[0054]...

Embodiment 2

[0056] (1) Take Radix Ophiopogon japonicus medicinal material, dry and grind at low temperature, use 5 times the amount of 80% ethanol to reflux extract twice, each time for 1 hour, combine the reflux liquid, recover the ethanol under reduced pressure, add 3 times the amount of distilled water to suspend, and use petroleum ether Extraction, the aqueous solution is then extracted 4 times with water-saturated n-butanol, the n-butanol extract is decompressed to recover n-butanol, adsorbed on a macroporous adsorption resin, eluted with water, 20% ethanol, and 70% ethanol respectively, and collect 4 times the amount 70% ethanol eluent, recover ethanol, put it on the alumina column for adsorption, wash with water until colorless, then elute with 4 times the amount of 80% ethanol, recover ethanol from the eluent, and apply the water-ethanol system gradient for HPLC preparative chromatography Separation and detection, collection of 80% ethanol eluted part, namely the ophioposide D of t...

Embodiment 3

[0059] (1) Take Radix Ophiopogon japonicus medicinal material, dry and grind at low temperature, use 6 times the amount of 90% ethanol to reflux extract twice, each time for 1 hour, combine the reflux liquid, recover ethanol under reduced pressure, add 4 times the amount of distilled water to suspend, and use petroleum ether Extraction, the aqueous solution was then extracted 5 times with saturated n-butanol, the n-butanol extract was decompressed to recover n-butanol, adsorbed on a macroporous adsorption resin, eluted with water, 20% ethanol, and 70% ethanol respectively, and collected 3 times the amount 70% ethanol eluent, recover ethanol, adsorb on alumina column, wash with water until colorless, elute with 5 times the amount of 70% ethanol, recover ethanol from eluent, and apply water-ethanol system gradient for HPLC preparative chromatography Separation and detection, collection of 80% ethanol elution fraction, namely to obtain Ophioside D;

[0060] (2) Take 1 g of Ophiop...

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PUM

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Abstract

A Chinese medicine in the form of liquid injection, perfusion, or powder injection for treating chronic bronchitis is proportionally prepared from ophiopogon saponin D and medicinal auxiliary through mixing.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a preparation with ophiopogon saponin D extracted from the traditional Chinese medicine Radix Ophiopogon japonicus as an active ingredient and a preparation method thereof, and the application of the preparation in the preparation of medicines for treating chronic bronchitis. The inventive preparation is also called Ophiopogon saponin D preparation. Background technique [0002] Chronic bronchitis (referred to as "old chronic bronchitis" and emphysema) is currently referred to as chronic obstructive pulmonary disease (COPD), or "COPD" for short. This is a very common chronic respiratory disease, characterized by long-term recurrent cough, expectoration, wheezing and acute respiratory infection. Over time, it develops into cor pulmonale, and even heart and lung failure. All bring many bad influences to individual, family and society. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704
Inventor 张海峰
Owner 张海峰
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