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Gastrointestinal ultrasonic contrast medium with echo and its preparation process

The technology of an ultrasonic contrast agent and a manufacturing method, which is applied in the field of medical supplies, can solve the problems that the light spot is easy to cause artifacts, the particles are large, and the brewing is cumbersome.

Inactive Publication Date: 2006-01-18
蓝锋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The contrast agent recorded in the first two patent applications is composed of traditional Chinese medicine formula. Although it has a certain health care effect, the ultrasonic image display effect is average, and the modulation method is relatively complicated and cumbersome. , it will cause artifacts and affect the diagnostic effect
"Tianxia" brand gastrointestinal ultrasound contrast aids have disadvantages such as large particles, uneven echo, easy separation of water and contrast agent (solute), formation of light spots and easy to cause artifacts, etc., thus affecting its diagnostic effect.
However, the "Xinzhang" gastric window acoustic contrast agent has the disadvantages of cumbersome brewing, easy agglomeration and deposition, and the formation of light spots that affect diagnosis.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Preparation of granular echogenic gastrointestinal ultrasound contrast agent

[0017] According to the proportion, take 25g of apple meal, 20g of corn, 5g of lotus root flour, fry or boil the apple meal and corn, and then pulverize the apple meal, corn flour and lotus root flour using micro-nano technology. The granules are 100 nanometers-15 micrometers powder, and they are sterilized at the same time by high temperature. Then they are mixed, granulated and packaged using activation technology to make granular echogenic gastrointestinal ultrasound contrast agents.

[0018] When in use, the granular echogenic gastrointestinal ultrasound contrast agent is modulated into a paste with boiling water, and taken by the person undergoing gastrointestinal ultrasound contrast. The clinical B-ultrasound image shows that the effect is excellent and the contrast is very clear.

Embodiment 2

[0019] Example 2: Preparation of powder-type echogenic gastrointestinal ultrasound contrast agent

[0020] According to the proportion, take 25g of apple meal, 20g of corn, 5g of lotus root flour, fry or boil the apple meal and corn, and then pulverize the apple meal, corn flour and lotus root flour using micro-nano technology. The granules are 100 nanometers to 15 micrometers powder, which are sterilized at the same time by high temperature, and then mixed with activation technology, and then packaged according to the specified weight standard (50 g / bag, 100 g / bag), which is made into a powder form with echo Gastrointestinal ultrasound contrast agent.

[0021] When in use, the powder-form echo gastrointestinal ultrasound contrast agent is modulated into a paste with boiled water, and it is taken by the person undergoing gastrointestinal ultrasound contrast. The clinical B-ultrasound image shows that the effect is excellent and the contrast is very clear.

Embodiment 3

[0022] Example 3: Preparation of solvent-based echogenic gastrointestinal ultrasound contrast agent

[0023] According to the proportion, take 25g of apple meal, 20g of corn, 5g of lotus root flour, fry or boil the apple meal and corn, and then pulverize the apple meal, corn flour and lotus root flour using micro-nano technology. The granule is 100 nanometer -15 micron powder, which is sterilized by high temperature at the same time, and is mixed by activation technology to make a powder-type echogenic gastrointestinal ultrasound contrast agent, and then, by portion (50 g / bag) The powder-type echogenic gastrointestinal ultrasound contrast agent is placed in the container, and 500 ml of aqueous solution is added, and it is fully stirred evenly. After disinfection and aseptic treatment, it is packaged to make solvent-based echo gastrointestinal ultrasound. Contrast agent.

[0024] The solvent-based echogenic gastrointestinal ultrasound contrast agent is easy to take. When in use, op...

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PUM

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Abstract

The invention discloses a gastrointestinal ultrasonic contrast medium with echo and its preparation process, wherein the contrast agent is prepared from distilled apple grain, maize flour and lotus root starch as raw material, and the contrast agent is made into the forms of particles, powders and solvents through three different techniques. The prepared contrast agent has good taste and causes no side effect to stomach and intestine.

Description

1. Technical Field: [0001] The invention relates to a contrast agent for checking gastrointestinal diseases and a preparation method thereof, and belongs to the technical field of medical supplies. 2. Background technology: [0002] At present, there are many kinds of contrast agent products used in the ultrasonic diagnostic examination of gastrointestinal diseases. Representative examples include: Bo Yuxia applied for gastrointestinal color ultrasound contrast agent patent (patent application number CN1403160) and Zhang Fudong applied for gastrointestinal Color ultrasound contrast agent patent (patent application number CN1535730), as well as the "Xinzhang" brand gastrointestinal ultrasound contrast agent produced by Hu Qingyutang in Hangzhou, Zhejiang Province and the "Tianxia" brand gastrointestinal ultrasound contrast agent produced by Huzhou Dongya Medical Supplies Co., Ltd. . The contrast agent described in the first two patent applications is composed of a traditional Chin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/06
Inventor 蓝锋
Owner 蓝锋