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Medicine for treating nephrolithiasis and its preparation method

A technology of kidney stones and drugs, which is applied in the field of traditional Chinese medicine, can solve the problems of stone removal and kidney damage, and achieve the effect of preventing stone formation and stone recurrence

Inactive Publication Date: 2010-06-09
王劲松
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides a medicine for treating kidney stones and a preparation method thereof, so as to solve the problem that traditional Chinese medicines are used to expel stones and damage the kidneys and are only limited to medium and small stones

Method used

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  • Medicine for treating nephrolithiasis and its preparation method
  • Medicine for treating nephrolithiasis and its preparation method
  • Medicine for treating nephrolithiasis and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0022] Experimental example 1, the present invention is to the influence of dog's blood pressure, kidney volume, urine output

[0023] 1. Experimental method: We use 31 healthy dogs, both male and female, with a general weight of about 8-12.5kg. Excluding 11 animals with incomplete data or other causes of death. 20 cases with complete information.

[0024] Twenty dogs were given general anesthesia with pentobarbital sodium 50mg / kg.

[0025] After anesthesia, the common carotid artery was intubated, and the blood pressure of the common carotid artery was recorded directly on the tattoo drum.

[0026] Incision was made in the middle of the abdomen, and then the left kidney was found, its outer membrane was peeled off, and then fixed with a renal volume device, connected to the Marie's air drum, and recorded on the drum surface. Changes in renal volume can be recorded to indirectly understand changes in renal blood flow.

[0027] Find out the left ureter, dissociate it, perfo...

experiment example 2

[0043] Experimental Example 2. Mechanism of "Rongshisu Tablets" Formula on Rabbit Jejunum Smooth Muscle

[0044] 1. Materials and methods: Choose healthy and large-weight rabbits, ten of both sexes, and intravenously anesthetize them with ethyl carbamate at 1.0 g / kg. After general anesthesia, an incision was made in the middle of the abdomen to find out the jejunum, and a 2.0cm jejunum smoother was used to cut the intestine. Put it in a McFarland dish and connect the lever for tracing.

[0045] Record the amplitude. Add 10%-8.0ml / kg "Longshisu Tablets" into the Mai's bath. The amplitude was recorded and compared with before and after administration.

[0046] 2. Results and Discussion: Five minutes after administration, the frequency of contraction (increase in tension) and the amplitude of contraction were obviously increased.

[0047] "Longshisu Tablets" have obvious excitatory effect on rabbit jejunal smooth muscle, and promote the contraction of smooth muscle.

[0048]...

experiment example 3

[0053] Experimental Example 3, Long-term Toxicity Test Report of Rongshisu Tablets

[0054] 1. Materials and methods

[0055] 1. Animals: 50 white rats were raised in the animal room of Changchun College of Traditional Chinese Medicine, weighing 80-110 grams, half male and half male, randomly divided into four groups, routinely fed during the administration period, and the conditions of each group were the same.

[0056] 2. Drugs: Lysolith tablets produced by the preparation room of the Affiliated Hospital of Changchun College of Traditional Chinese Medicine, powdered drugs and distilled water to make suspensions with required concentrations.

[0057] 3. Method: The experiment is divided into 4 groups

[0058] The first group: the control group, with normal saline 1ml / 100g body weight gavage, once a day, a total of three weeks.

[0059] The second group: low-dose group (equivalent to clinical dosage for adults), given 5% lysolithin tablets 0.108ml / 100g body weight, orally, o...

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Abstract

The present invention belongs to the field of Chinese medicine technology. The medicine for treating nephrolithiasis is prepared with 16 kinds of Chinese medicinal materials including lysimachia herb,climbing fern spore, selfheal, schisandra, epimedium, etc. The medicine has the functions of invigorating kidney, dissolving stone and removing urinary calculus, and thus the effects of preventing and treating nephrolithiasis.

Description

technical field [0001] The invention relates to a medicine for treating kidney stones and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Kidney calculus is a common and frequently-occurring disease. With the progress of society and the improvement of people's living standards, and the change of people's eating habits, its incidence has gradually increased in recent years. When the disease and its stones break out, the patient will suffer from colic and hematuria, which are painful and cause great harm to the patient. [0003] At present, the treatment of this disease at home and abroad has encountered the following thorny problems: [0004] 1. There are two types of traditional Chinese medicine for the treatment of kidney stones. One is the single-effect diuretic-based stone-dispelling method, which is the traditional method. Diuretic and stone-dispelling methods can damage the kidneys. [0005] 2. Tradi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/815A61K36/73A61K36/71A61K36/66A61K36/57A61K36/536A61K36/53A61K36/484A61K36/481A61K36/39A61K36/296A61K36/185A61K36/11A61K35/64A61K35/37A61K33/12A61K9/28A61P13/04A61P13/12A61K35/57A61K35/62
Inventor 王劲松
Owner 王劲松
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