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Therapeutic agents for drug/substance dependence

A material dependence and drug technology, applied in the direction of drug combination, pharmaceutical formula, organic active ingredients, etc., can solve the problems of dependence, non-display effect, cost, etc.

Inactive Publication Date: 2006-04-12
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Once you regularly use natural substances such as opium, cocaine, and marijuana, specific drugs such as heroin, barbiturates, and stimulants, or organic solvents such as thinners and toluene, you cannot stop using them, and it takes a lot of money to obtain these substances
When people often use alcohol (alcohol) or smoking (nicotine), which are closely related to daily life, there is also a common problem: the drugs and substances contained in these substances produce mental or physical dependence
[0007] In general, drugs with a site of action in the central nervous system (inside the brain), despite showing high activity in in vitro evaluations at the cellular level, often actually show little effect in in vivo evaluations of animal administration

Method used

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  • Therapeutic agents for drug/substance dependence
  • Therapeutic agents for drug/substance dependence
  • Therapeutic agents for drug/substance dependence

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Lipid Solubility Evaluation of Compounds Using Partition Coefficient as Index

[0041] There is a barrier called the blood-brain barrier when it penetrates from the blood to the brain, and high fat solubility is an important factor when it penetrates into the brain. One of the parameters for evaluating the fat solubility of a compound is the partition coefficient P, which is defined as the ratio of the concentration of the compound in n-octanol to the concentration of the compound in water. The larger the value shown, the higher the fat solubility of the compound . The distribution coefficient P can be obtained by calculation in addition to being obtained by experiment. For compounds 1-4, use CS Chem Draw R (CambridgSofi)it calculates the logarithmic logP value of the distribution coefficient P reported by Crippen et al. (Crippen, G.M. et al., J.Chem.Inf.Comput.Sci., 27, 21, 1987), and the calculated results are shown in Table 1. In addition, Compounds 1 and 3 are ...

Embodiment 2

[0049] The promoting effect of compound 1 on the recovery process after the acquisition of mental dependence produced by stimulants (Xing Stimulant dependence treatment effect)

[0050] For the promotion effect of compound 1 in the recovery period after obtaining psychotropic dependence produced by stimulants, by the Conditioned Palace Preference method-(Suzuki, T, et al., Psychopharmacology, 102, 438, 1990; Spyraki, C., The psychopharmacology of addiction , p96, Oxford Medical Publication, New York, 1988: hereinafter referred to as the CPP method) for analysis. Use of methamphetamine hydrochloride as a stimulant for psychotropic dependence. And compound 1 is used as drug dependence treatment drug.

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PUM

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Abstract

The present invention relates to therapeutic agents for drug / substance dependence containing a compound represented by the following compound: as an active ingredient. The therapeutic agents are excellent in the capability to penetrate into the brain, can promote the recovery from the state of psychologycal and physical dependence on dependence drugs / substances, can inhibit the craving and exacerbation, and are useful for the drug therapy of drug / substance dependence and drug / substance dependence patients.

Description

technical field [0001] The present invention aims to provide a medicine for treating drug and substance dependence. The so-called drugs and substances are, for example, dependent drugs and substances having a central stimulating effect, especially amphetamine-type drugs (stimulants), cocaine-type drugs, hallucinogen (LSD)-type drugs, nicotine, etc., and dependent drugs and substances having a central depressant effect. Sexual drugs and substances, especially alcohol / barbiturate type drugs, morphine type drugs, cannabis type drugs, organic solvent type drugs, benzodiazepines and other psychotropic drugs, especially two or more of the above Combination of drugs and substances. In the present invention, it is intended to provide a drug and substance dependence treatment drug having excellent brain permeability, which is not treated according to conventional symptomatic therapy in the treatment of drug and substance dependence caused by the above drug and substance , but inhibit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61P25/30C07D489/00
CPCA61K31/485C07D489/00A61P25/30A61P25/36
Inventor 长谷部光铃木知比古藤井秀明铃木勉
Owner TORAY IND INC
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