Use of tanshinone derivates as cholinesterase inhibitors in treating related diseases

A technology of acetylcholine and tanshinone is applied in the application field of tanshinone as an acetylcholinesterase inhibitor in the treatment of related diseases, and can solve problems such as neurotoxicity

Inactive Publication Date: 2006-04-26
THE CHINESE UNIVERSITY OF HONG KONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nonspecific BuChE inhibition accompanied by A

Method used

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  • Use of tanshinone derivates as cholinesterase inhibitors in treating related diseases
  • Use of tanshinone derivates as cholinesterase inhibitors in treating related diseases
  • Use of tanshinone derivates as cholinesterase inhibitors in treating related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Preparation of Salvia miltiorrhiza plant water extract

[0064] 10 g of Salvia miltiorrhiza from Hebei (Hibei) was purchased from Hong Kong Tongrentang Co., Ltd. The root of Salvia miltiorrhiza was boiled in 80 ml of distilled water under reflux for 45 minutes. The decocted extract was filtered and the clear filtrate was freeze-dried. The lyophilizate in powder form was weighed (2 g).

Embodiment 2

[0066] Preparation of Ethanol Extract from Salvia Miltiorrhiza

[0067]Soak 10 g of dried Salvia miltiorrhiza in 50 ml of absolute ethanol overnight. Save the unfiltered extract and repeat the whole process (ie soak the herb again with another 50ml of absolute ethanol). The total 100ml extract was filtered through 3M filter paper and freeze-dried. The lyophilized material was weighed (100 mg) as a viscose.

[0068] Cryptotanshinone

[0069] All ingredients were mixed well and made into 100 pieces.

[0070] The extract obtained in embodiment 2

[0071] The ethanol extract obtained in Example 2 was dissolved in 100 ml of 50% DMSO aqueous solution to obtain a working solution.

[0072] Dihydrotanshinone I

[0073] Mix dihydrotanshinone I, cornstarch and lactose evenly. A very small amount of water is added to the mixture. The resulting material was filtered and dried. Add magnesium stearate to the mixture and mix well. The product was tableted...

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Abstract

The present invention provides novel uses of tanshinone derivatives as acetylcholinesterase inhibitors, and in diseases associated with depletion of acetylcholine, such as Alzheimer's disease, insomnia, vascular dementia, memory loss, attention disorders, and other sleep disorders. New uses in the treatment of cognitive impairment diseases. The active compound is generally found in the roots of Salvia genus, especially Salvia miltiorrhiza.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of identically titled US Patent Application Serial No. 10 / 396,862, filed March 24, 2003, which is expressly incorporated herein by reference in its entirety. field of invention [0003] The present invention provides new uses of tanshinone derivatives as acetylcholinesterase inhibitors, and new uses thereof in the treatment of diseases related to acetylcholine depletion such as cognitive impairment. Background of the invention [0004] Alzheimer's disease (AD) is a neurodegenerative disease affecting 11% and 50% of the population over 65 and 85 years, respectively. There are currently no cured cases of AD. One of the neuropathological manifestations in AD is the depletion of the major neurotransmitter of the basal forebrain - acetylcholine. The only drug currently approved by the FDA for the treatment of AD is based on its inhibitory activity on acetylcholinesterase (AChE), thereby...

Claims

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Application Information

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IPC IPC(8): A61K31/343A61K31/12A61K36/00A61K36/537A61P25/00A61P25/20A61P25/28
CPCA61K31/12A61K36/537A61P25/00A61P25/20A61P25/28
Inventor 邵鹏柱何旨云冯国培温志昌
Owner THE CHINESE UNIVERSITY OF HONG KONG
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