Use of tanshinone derivates as cholinesterase inhibitors in treating related diseases

A technology of acetylcholine and tanshinone is applied in the application field of tanshinone as an acetylcholinesterase inhibitor in the treatment of related diseases, and can solve problems such as neurotoxicity
CN1764447AInactive Publication Date: 2006-04-26THE CHINESE UNIVERSITY OF HONG KONG
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
THE CHINESE UNIVERSITY OF HONG KONG
Publication Date
2006-04-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides novel uses of tanshinone derivatives as acetylcholinesterase inhibitors, and in diseases associated with depletion of acetylcholine, such as Alzheimer's disease, insomnia, vascular dementia, memory loss, attention disorders, and other sleep disorders. New uses in the treatment of cognitive impairment diseases. The active compound is generally found in the roots of Salvia genus, especially Salvia miltiorrhiza.
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Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit of identically titled US Patent Application Serial No. 10 / 396,862, filed March 24, 2003, which is expressly incorporated herein by reference in its entirety. field of invention

[0003] The present invention provides new uses of tanshinone derivatives as acetylcholinesterase inhibitors, and new uses thereof in the treatment of diseases related to acetylcholine depletion such as cognitive impairment. Background of the invention

[0004] Alzheimer's disease (AD) is a neurodegenerative disease affecting 11% and 50% of the population over 65 and 85 years, respectively. There are currently no cured cases of AD. One of the neuropathological manifestations in AD is the depletion of the major neurotransmitter of the basal forebrain - acetylcholine. The only drug currently approved by the FDA for the treatment of AD is based on its inhibitory activity on acetylcholinesterase (AChE), thereby...

Claims

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