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Orally administered formulation of eight ingredients-containing 'Xi Lei San' and its colon target oral formulation and preparation method

A technology of oral preparations and tin powders, which is applied in the field of Bawei tin powder oral preparations and its colon-targeted oral preparations and preparations, can solve the problems of high technical difficulty and no such products listed on the market, and achieve product control Quality, improve the quality standard of traditional Chinese medicine, the effect of definite curative effect

Inactive Publication Date: 2006-05-03
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral colon-targeted drug delivery of traditional Chinese medicine is technically difficult. There are few such research reports in China, and no such products have been listed on the market.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 12、 8

[0107] Example 12 Bawei Xilei powder oral colon-specific drug delivery capsule formulation was obtained according to the following steps:

[0108] (1) Indigo Naturalis, Bezoar, Pearl (tofu broiled), borneol, watermelon frost, cold water stone, borax, and Naosha (roasted) are dried in proportion to reserve; the drying time is 30 minutes; the drying temperature is controlled at 75°C;

[0109] (2) Crush the dried medicinal materials for later use;

[0110] (3) Granules are formed by high-speed stirring granulation method or fluidized bed granulation method; HPMC is used as binder, and the amount is 5%; MCC and L-HPC are disintegrants, and the amount is 3%, respectively. 4%, the temperature is controlled at 30℃, the rotation speed is 45 revolutions, and the time is 3 minutes, drying, granulating, and obtaining granules;

[0111] (4) Pellets forming;

[0112] (a) First, the dry and crushed material is added with a wetting agent to make a soft material, where the total amount of wetting...

Embodiment 13

[0117] Example 13. Multiple groups of Bawei Xilei San ordinary oral preparations and multiple groups of Bawei Xilei San oral colon-targeted preparations.

[0118] It is an oral preparation made of the following raw materials with a weight ratio: 1 part of Indigo Naturalis, 5 parts of bezoar, 1 part of pearl (tofu roast), 5 parts of borneol, 1 part of watermelon frost, 10 parts of cold water stone, 1 part of borax, Naosha (sunburn) 5 parts.

[0119] The rest repeat Example 1, Example 2, Example 3, Example 4, Example 5, Example 6, Example 6, Example 7, Example 8, Example 9, Example 10, and Example 11. , Example 12.

Embodiment 14

[0120] Example 14. Multiple groups of Bawei Xilei San ordinary oral preparations and multiple groups of Bawei Xilei San oral colon-targeted preparations.

[0121] It is an oral preparation made of raw materials with the following weight ratios: 15 parts of Indigo Naturalis, 1 part of Bezoar, 5 parts of pearls (tofu roast), 1 part of borneol, 6 parts of watermelon frost, 1 part of cold water stone, 5 parts of borax, Naosha (sunburn) 1 part.

[0122] The rest repeat Example 1, Example 2, Example 3, Example 4, Example 5, Example 6, Example 6, Example 7, Example 8, Example 9, Example 10, and Example 11. , Example 12.

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PUM

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Abstract

The invention provides an orally administered formulation of eight ingredients-containing 'Xi Lei San' and its colon target oral formulation and preparation method by changing enema administration into oral administration large intestine targeted treatment, the medicinal preparation can increase the focus medicinal concentration, improve adaptability for the patients, reduce stomach and intestine stimulation, thus improve treating effects.

Description

Technical field [0001] The invention relates to an oral preparation of Bawei Xilei powder, a colon-targeted oral preparation and a preparation method thereof. Background technique [0002] Ulcerative colitis is a common clinical disease, frequently-occurring disease, and one of the intractable diseases recognized by the World Health Organization. Because of its long course, lingering and difficult to heal, it seriously affects the patient's quality of life and physical and mental health. According to reports, the prevalence rate of people aged 30-60 years old is 1-1.5‰, and with the improvement of people's living standards, the dietary structure changes, and the incidence of ulcerative colitis in my country is showing a significant upward trend. [0003] At present, there is no clinically effective drug for the treatment of ulcerative colitis. The clinical western medicines are mainly aminosalicylic acid and corticosteroids, which generally require long-term medication, and they ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/42A61K9/00A61K33/06A61K33/20A61K33/22A61K35/413A61K35/618A61K36/70A61P1/04
Inventor 吕爱平罗晓健龚建平饶小勇张任刘端勇陈爱民杨世林
Owner JIANGXI HERBFINE HI TECH
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