Method and apparatus for enhanced nano-spectroscopic scanning

A nano-lens technology, applied in the field of nano-spectral scanning, can solve the problems that have not been disclosed or proposed, and have not been proposed to read out multiple samples in parallel

Inactive Publication Date: 2006-05-03
VP HLDG LLC
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  • Abstract
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  • Claims
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Problems solved by technology

This patent does not disclose or suggest a method for using electromagnetic gap modes to increase the spectral resolution that can be used to analyze a single chemical structure, such as a DNA base, nor does it suggest a system capable of parallel readout of multiple samples, such as stretched DNA strings

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  • Method and apparatus for enhanced nano-spectroscopic scanning

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Embodiment Construction

[0036] I. Definition

[0037] The following terms have the following meanings, unless otherwise stated, "plasmon resonance metal" includes any metal, such as gold, silver or aluminum, which can support surface electromagnetic modes - surface plasmon polarization (SPP), i.e. photons and plasmons Coupling modes of bulk oscillators.

[0038] A "chemical group" in a sample may include a subunit or part of a subunit in a polymer, such as a nucleic acid group, or a chemically substituted molecular group, such as a hydroxyl, amine, alkyl, acid or aldehyde group. These chemical groups are characterized by characteristic enhanced Raman spectral signatures or features.

[0039] "Gap mode" refers to electromagnetic conventional modes or electromagnetic eigenmodes that are placed near a metal surface by an external electromagnetic field located in the gap between two or more plasmon resonant particles (less than 40nm), especially when the plasmon resonance is excited on the metal surf...

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Abstract

The present invention discloses an apparatus and method for identifying chemical groups in a sample (82). The device (35) comprises: a substrate (80) having a plasmon resonant surface supporting a sample (82), a beam source (10), and one or more plasmon particles ( A lens assembly (60) of nanolenses composed of PRP). Arranging the PRP in the space between the nanolens (62) and the resistive detection zone on the substrate surface (80), when the gap between the nanolens (62) and the substrate (80) is 30nm or less, a near field is generated Electromagnetic gap mode. The focusing mechanism in the device is used to move the lens assembly (60) towards or away from the substrate surface (80), and the gap is less than 30nm, thereby generating an electromagnetic gap mode for enhancing Raman spectroscopic signals, the A signal is generated from the sample (82) in the detection zone.

Description

technical field [0001] The invention relates to the field of nanometer-spectral scanning, in particular to a method and device capable of performing spectral identification on single molecules or single chemical groups attached to substrates. Background technique [0002] The following references are provided as background in part to the present invention and / or to provide ways in which certain aspects of the invention might be used. These materials are incorporated herein by reference. [0003] G. R. Brewer, Electron-Beam Technology in Microelectronic Fabrication, Academic Press, NY, (1980). [0004] "The evolution of Dip-Pen Nanolithography" by David Ginger et al., Angew. Chem. Int. Ed., v.43, p.30-45, (2004). [0005] S. Hayashi, "Spectroscophy of Gap Modes in Meta Paricle-Surface Systems", Tpoics Appl Phys 81: 71-95 (2001). [0006] "Ultrasensitive Chemical Analyzes by Raman Spectroscophy" by I-K. Kneipp et al., Chem. Rev., 1999, Vol.99, p.2957-2975, see p.271. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01J3/44G01N21/65G01Q60/18
CPCB82Y15/00B82Y20/00G01N21/658G01N2021/656G02B5/204G01J3/44
Inventor V·波波尼恩
Owner VP HLDG LLC
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