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Expanding diuretic for treating pulmonary edema in perioperative period of hepatic and biliary diseases

A diuretic and perioperative technology, applied in the field of volume expansion diuretics, can solve problems such as shock, aggravated pulmonary edema, and unstable blood circulation

Inactive Publication Date: 2006-05-17
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinicians often use conventional diuretics (such as furosemide, etc.) to correct pulmonary edema damage and improve oxygenation, but it can easily lead to unstable blood circulation or even shock
If a large amount of fluid or albumin is infused to maintain stable blood circulation, it may lead to further aggravation of pulmonary edema

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: Preparation of expansion diuretic A

[0014] Human albumin: furosemide=10: 0.02 (w / w), prepare with water for injection, albumin concentration 10%, furosemide concentration 0.02%, pack into 100ml / bag after filtering, use 60 Store at 2-8°C in the dark after being sterilized by Co γ-ray irradiation.

Embodiment 2

[0015] Embodiment 2: Preparation of expansion diuretic B

[0016] Human albumin: furosemide=10:0.04 (w / w), the concentration of albumin is 10%, the concentration of furosemide is 0.04%, and the preparation method is the same as in Example 1.

Embodiment 3

[0017] Embodiment 3: Preparation of expansion diuretic C

[0018] Human albumin: furosemide=20:0.01 (w / w), the concentration of albumin is 20%, the concentration of furosemide is 0.01%, and the preparation method is the same as in Example 1.

[0019] The three volume-expanding diuretics above A, B, and C are sequentially balanced type, diuretic type and volume-expanding type.

[0020] Clinical trials:

[0021] 1. Patients with acute lung injury after liver transplantation

[0022] 40 cases of patients after liver transplantation were observed successively by random method, among which 20 cases were used as the treatment group, and the other 20 cases were used as the control group. The treatment group received intravenous infusion of type A volume diuretic three times a day, 100ml each time, for three days; the control group received intravenous infusion of furosemide and albumin respectively, with the same dose and method as the treatment group. Urine volume, blood pressure...

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PUM

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Abstract

The present invention relates to medicine technology, and is especially one kind of expanding diuretic for treating pulmonary edema in perioperative period of hepatic and biliary diseases used in, say, clinical liver transplanting operation. The expanding diuretic consists of human albumin and furosemide in the weight ratio of 10-20 to 0.01-0.06, and is compounded with water for injection to the concentration of human albumin and furosemide in 10-20 % and 0.01-0.06 % separately. Clinical trial shows that the expanding diuretic with mixed human albumin and furosemide has curative effect obviously superior to that of human albumin or furosemide and less side effect. The present invention can prevent pulmonary edema in perioperative period, expand to stabilize blood circulation and avoid kidney failure.

Description

technical field [0001] The invention relates to the technical field of medicine, and is a volume-expanding diuretic used for preventing and treating pulmonary edema in the perioperative period of hepatobiliary surgery such as clinical liver transplantation. Background technique [0002] Clinically, a series of complications such as pulmonary edema injury, circulatory instability, and acute renal failure often occur in the early stage after liver transplantation, which seriously affects the early recovery and survival rate after liver transplantation. Clinicians often use conventional diuretics (such as furosemide, etc.) to correct pulmonary edema damage and improve oxygenation, but it can easily lead to unstable blood circulation or even shock. If a large amount of fluid or albumin is infused to maintain stable blood circulation, it may lead to further aggravation of pulmonary edema. Therefore, how to ensure stable blood circulation while improving p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/38A61K31/341A61P7/10
Inventor 李泉俞卫锋杨广顺杨甲梅周脉涛姜小青
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY