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Preparation process of Chinese medicine soft capsule

A technology of soft capsules and traditional Chinese medicine, which is applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve the problems that there are no beneficial hints for soft capsules and cannot be fully used.

Inactive Publication Date: 2006-06-07
RENHE GRP DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the content of the soft capsule must be made into a uniform and stable non-solid system, it is impossible to completely follow the traditional solid preparation or liquid preparation process. Only by making appropriate process improvements can the purpose of preparing soft capsules be achieved.
A preparation method of "Kanggongyan Tablets" is disclosed in CN1092983A, but there is no helpful hint about preparing soft capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1: Take 5511g of Guangdong Zizhu, 616g of motherwort and 702g of black medicine, add 12 times the amount of water, decoct 2 times, 1.5 hours each time, combine the decoction, filter, and the relative density of the filtrate is 1.05~ when concentrated at 60°C 1.10 of the extract, let it cool, add ethanol to make the alcohol content reach 50%, let it stand for 12 hours, filter, recover the ethanol from the filtrate, and continue to concentrate to an extract with a relative density of 1.15-1.20 at 60°C, and spray dry it into Fine powder, add 1.1 times the amount of PEG-400 and 0.05 times the amount of beeswax, and make soft capsules after colloid milling.

Embodiment 2

[0013] Example 2: Take 5511g of Guangdong Zizhu, 616g of Motherwort and 702g of Wuyao, add 10 times the amount of water, decoct 2 times, each time for 1 hour, combine the decoctions, filter, and the relative density of the filtrate is 1.05~ when concentrated at 60°C 1.10 of the extract, let it cool, add ethanol to make the alcohol content reach 40%, let it stand for 12 hours, filter, recover the ethanol from the filtrate, and continue to concentrate to an extract with a relative density of 1.15-1.20 at 60°C, and spray dry it into Fine powder, add 1 times the amount of soybean oil and 0.05 times the amount of beeswax, and make soft capsules after colloid milling.

Embodiment 3

[0014] Example 3: Take 5511g of Guangdong Purple Pearl, 616g of Motherwort and 702g of Wuyao, add 16 times of water, decoct 3 times, 2 hours each time, combine the decoction, filter, and the relative density of the filtrate is 1.10-1.15 when concentrated at 60°C Add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, filter, reclaim the ethanol from the filtrate, and continue to concentrate to the extract with a relative density of 1.15-1.20 at 60 ° C, spray dry into fine powder, press Peanut oil, beeswax and lecithin are added in a weight ratio of 1:0.92:0.03:0.02, colloid milled to make a soft capsule.

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Abstract

The present invention discloses the preparation process of soft Chinese medicine capsule. On the basis of available recipe, the present invention adopts water extraction and alcohol precipitation process and adds proper amount of dispersant and suspension assistant to make the product obtain homogeneous and stable quality.

Description

technical field [0001] The invention discloses a preparation method of a traditional Chinese medicine soft capsule, which belongs to the field of traditional Chinese medicine. Background technique [0002] At present, there is a traditional Chinese medicine "Kanggongyan Tablet" on the market, which is used for the treatment of chest and abdomen distension and pain, dyspnea and shortness of breath, bladder deficiency and cold, enuresis, frequent urination, xenon gas, dysmenorrhea, etc., and has good clinical application effect. However, due to the poor acceptability of tablets among patients, the promotion of the drug in the market has been seriously affected; on the other hand, patients hope to have a drug with equivalent efficacy and more advanced dosage form to meet their needs. Therefore, the development of new products will contain a huge market space. [0003] Soft capsules are an emerging development direction in the field of traditional Chinese medicine. They are gra...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61K9/48A61P15/00
Inventor 杨文龙曾雄辉刘云
Owner RENHE GRP DEV CO LTD
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