Fortifier
A technology of enhancer and inhibitor, applied in the field of drugs for the treatment or prevention of kidney disease, can solve the problem of unrecognized effects, and achieve excellent inhibitory effect, effective treatment, and safe treatment.
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Embodiment 1
[0133] Example 1 Rabbit anti-rat glomerular basement membrane antiserum (NTS, diluted 10 times, 3ml / kg) was administered to 9-week-old WKY rats derived from Japan's Chuya-ruzuliba-induced glomerulonephritis. Two weeks later, urine and blood were collected, and the test animals were divided into 6 groups according to the amount of urine protein and serum creatinine value, and the administration was started. At this time, the serum creatinine value has risen, and it can be judged that it can be classified as the stage of renal failure. Renal function was evaluated based on serum creatinine values.
[0134] 1) Control group: only given solvent, n=6
[0135] 2) BPS100 group (comparative example): Bereprosodium 100 μg / kg (BID: this dosage is given twice a day), n=6
[0136] 3) BPS300 group (comparative example): Berepro sodium 300 μg / kg (BID), n=6
[0137] 4) Candesartan 10 group (comparative example): candesartan cilexetil 10 mg / kg (OAD: this dosage is given once a day), n=6
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Embodiment 2
[0145] Example 2 Nephritis was induced by administering rabbit anti-rat glomerular basement membrane antiserum to 9-week-old WKY rats. Two weeks after the administration of the antiserum, the test animals were divided into the following 4 groups, and the administration was started.
[0146] 1) Control group: 0.5% CMC (OAD) + distilled water (BID), n=6
[0147] 2) Telmisartan group (comparative example): Telmisartan 40 mg / kg (OAD) + distilled water (BID), n=5
[0148] 3) BPS group (comparative example): 0.5% CMC (OAD) + bereprosodium 100 μg / kg (BID), n=5
[0149] 4) Telmisartan+BPS group (the present invention): Telmisartan 40 mg / kg (OAD) + Berepro sodium 100 μg / kg (BID), n=6.
[0150] As shown in Table 1, there was almost no difference in the effect of suppressing the progression of renal failure in the BPS group compared with the control group. Both telmisartan group and telmisartan+BPS group could inhibit the worsening of renal failure, and the inhibitory effect of telmis...
Embodiment 3
[0154] Nephritis was induced by administering rabbit anti-rat glomerular basement membrane antiserum to 9-week-old WKY rats. Two weeks after the administration of the antiserum, the test animals were divided into the following 4 groups, and the administration was started.
[0155] 1) Control group: 0.5% CMC (BID) + distilled water (BID), n=6
[0156] 2) Losartan group (comparative example): Losartan 30mg / kg (BID) + distilled water (BID), n=5
[0157] 3) BPS group (comparative example): 0.5% CMC (BID) + bereprosodium 100 μg / kg (BID), n=6
[0158] 4) Losartan+BPS group (the present invention): Losartan 30 mg / kg (BID) + Berepro sodium 100 μg / kg (BID), n=5
[0159] Serum creatinine was measured 6 weeks after nephritis was induced to evaluate the degree of deterioration of renal failure. As shown in Table 2, compared with the control group, the losartan group and the BPS group at this dosage have no difference in the inhibitory effect on the deterioration of renal failure. On t...
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