The invention discloses a method for determining impurities in
candesartan cilexetil. The method comprises the following steps: S1, heating a
candesartan cilexetil standard substance solution at 70-100 DEG C for 1.5-3 hours, cooling, and adding
acetonitrile to obtain a degradation solution 1; besides, adding the
candesartan cilexetil standard substance solution into an alkaline solution, performing standing for 5-30 minutes, and adding an acid solution for
neutralization to obtain a degradation solution 2; mixing the degradation solution 1 and the degradation solution 2 to obtain a
system applicability solution; S2, dissolving candesartan cilexetil to be detected, and quantitatively preparing a
test solution; diluting the
test solution as a control solution; and S3, respectively carrying out liquid
chromatography detection on the
system suitability solution obtained in the step S1, the
test solution obtained in the step S2 and the control solution, and determining the impurities A, B,C, D, E, F or G in candesartan cilexetil by comparing liquid chromatograms. The method is strong in pertinence, high in accuracy and easy to popularize, and has good application value in the aspect ofdetermining the impurities in candesartan cilexetil.